Mutations in multicopy Tn10 tet plasmids that confer resistance to inhibitory effects of inducers of tet gene expression

Experiments in molecular genetics

1972 • 28,260 citations

Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis

1975 • 1,135 citations

Positive selection for loss of tetracycline resistance

1980 • 704 citations

Analysis of Endonuclease R· Eco RI Fragments of DNA from Lambdoid Bacteriophages and Other Viruses by Agarose-Gel Electrophoresis

1974 • 633 citations

A simple method for the preparation of large quantities of pure plasmid DNA

1975 • 586 citations

Selection for loss of tetracycline resistance by Escherichia coli

1981 • 585 citations

Nucleotide sequence of an insertion element, IS1.

1978 • 319 citations

Detection of an inducible membrane protein associated with R-factor-mediated tetracycline resistance

1974 • 143 citations

Overlapping divergent promoters control expression of Tn10 tetracycline resistance

1983 • 135 citations

Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro

1981 • 126 citations

Organization of structural and regulatory genes that mediate tetracycline resistance in transposon Tn10

1979 • 120 citations

The nucleotide sequence and protein-coding capability of the transposable element IS5

1981 • 106 citations

Two complementation groups mediate tetracycline resistance determined by Tn10

1982 • 88 citations

Identification of the tetracycline resistance promoter and repressor in transposon Tn10

1981 • 84 citations

Multicopy Tn10 tet plasmids confer sensitivity to induction of tet gene expression

1983 • 72 citations

Cloned structural gene (ompA) for an integral outer membrane protein of Escherichia coli K-12

1980 • 69 citations

Analysis of the reduction in expression of tetracycline resistance determined by transposon Tn10 in the multicopy state

1981 • 62 citations

Cloning of phoE, the structural gene for the Escherichia coli phosphate limitation-inducible outer membrane pore protein.

1982 • 53 citations

Generation of miniplasmids from copy number mutants of the R plasmid NR1

1977 • 45 citations

Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes

1983 • 32 citations

Reduced Expression of Tn10-mediated Tetracycline Resistance in Escherichia coli Containing More Than One Copy of the Transposon

1981 • 32 citations

Plasmid-Mediated Tetracycline Resistance in E. coli

1977 • 31 citations