Alpha₁-Antitrypsin Deficiency

Liver Disease in Alpha₁-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

1976 • 787 citations

The Induction of Pulmonary Emphysema with Human Leukocyte Elastase^1–3

1977 • 335 citations

Liver Disease in Adults with Alpha₁-Antitrypsin Deficiency

1972 • 264 citations

Elastase Release from Human Alveolar Macrophages: Comparison Between Smokers and Nonsmokers

1977 • 172 citations

Neutral Proteases of Human Granulocytes III. Interaction between Human Granulocyte Elastase and Plasma Protease Inhibitors

1974 • 153 citations

CIRRHOSIS AND MALIGNANT HEPATOMA IN α₁‐ANTITRYPSIN DEFICIENCY

1974 • 136 citations

Inactivation of human α1-proteinase inhibitor by thiol proteinases

1977 • 112 citations

NEONATAL CHOLESTASIS IN ALPHA‐1‐ANTITRYPSIN DEFICIENT CHILDREN Clinical, Genetic, Histological and Immunohistochemical Findings

1972 • 100 citations

CHRONIC PANCREATITIS AND ALPHA-1-ANTITRYPSIN

1975 • 86 citations

Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects.

1975 • 84 citations

Histopathologic study of the liver in the early cholestatic phase of alpha-1-antitrypsin deficiency

1976 • 80 citations

HETEROZYGOUS ALPHA1-ANTITRYPSIN DEFICIENCY AND CIRRHOSIS IN ADULTS, A FORTUITOUS ASSOCIATION

1975 • 79 citations

Alpha1-Antitrypsin Deficiency and Liver Disease in Children: Phenotypes, Manifestations, and Prognosis

1976 • 76 citations

Liver, Lung and Malignant Disease in Heterozygous (Pi MZ) α₁‐antitrypsin Deficiency

1975 • 73 citations

α-1-Antitrypsin Deficiency in Liver Disease: The Extent of the Problem

1976 • 72 citations

Elastase, Collagenase, Emphysema, and Alpha1-Antitrypsin Deficiency

1976 • 70 citations

Liver disease associated with alpha1-antitrypsin deficiency in childhood

1976 • 70 citations

Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men.

1977 • 61 citations

On the inhibition of elastase by serum. Some distinguishing properties of α1-antitrypsin and α2-macroglobulin

1975 • 58 citations

Elastase-Like, Esteroprotease Activity in Human and Rabbit Alveolar Macrophage Granules

1971 • 52 citations

Genetic vs. Quantitative Analysis of Serum Alpha₁-Antitrypsin

1972 • 52 citations

Enhancement of migration inhibitory factor activity by plasma esterase inhibitors

1975 • 48 citations

Relation of alpha-1-antitrypsin phenotype to the performance of pulmonary function tests and to the prevalence of respiratory illness in a working population.

1976 • 48 citations

Alpha-1-antitrypsin bodies in the liver.

1977 • 46 citations

Liver disease in infancy: histological features and relationship to alpha-antitrypsin phenotype.

1975 • 44 citations

Neonatal hepatitis syndrome and alpha-1-antitrypsin deficiency: an epidemiological study in South-East England

1974 • 40 citations

Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.

1977 • 39 citations

Liver in α1-Antitrypsin Deficiency: Morphologic Observations and in Vitro Synthesis of α1-Antitrypsin

1976 • 34 citations

Alpha- 1 -antitrypsin deficiency and pulmonary emphysema: The role of proteolytic enzymes and their inhibitors

1973 • 33 citations

Obstructive Lung Disease in Heterozygotes for Alpha-1 Antitrypsin Deficiency

1974 • 31 citations

Pathologic patterns of chronic obstructive pulmonary disease in patients with normal and deficient levels of alpha1 antitrypsin

1973 • 28 citations

Antitrypsin Deficiency and Abnormal Protease Inhibitor Phenotypes

1973 • 28 citations

Alpha_1-Antitrypsin Deficiency and Pancreatic Fibrosis

1976 • 28 citations

Alpha-1-antitrypsin globules in the liver and PiM phenotype.

1977 • 26 citations

Pulmonary function in nonsmoking subjects with alpha1 antitrypsin deficiency (MZ phenotype)

1977 • 23 citations

Fluorescent Antibody Studies of Alpha-1-Antitrypsin in Adult Human Lung

1975 • 23 citations

Infantile Cirrhosis With Hereditary Alpha1-Antitrypsin Deficiency

1973 • 23 citations

Heterozygous Alpha-1-Antitrypsin Deficiency and Respiratory Function in Children

1977 • 19 citations

Alpha1 antitrypsin deficiency in chronic liver disease, and a report of cirrhosis and emphysema in adult members of a family.

1974 • 18 citations

The Lungs in Homozygous Alpha₁Antitrypsin Deficiency

1973 • 17 citations

Emphysema, Cirrhosis, and Hepatoma with Alpha-1 Antitrypsin Deficiency

1974 • 16 citations

Hereditary alpha1 ? Antitrypsin deficiency associated with congenital extrahepatic bile duct hypoplasia

1975 • 15 citations

1 Antitrypsin deficiency and liver disease in childhood: genetic, immunochemical, histological, and ultrastructural diagnosis

1974 • 14 citations

Smoking and Disease

1975 • 14 citations

Alpha 1-antitrypsin deficiency and infantile liver disease.

1976 • 14 citations

Human Alveolar Macrophage Proteolytic Enzyme Activities in Chronic Obstructive Pulmonary Disease

1978 • 11 citations

Proceedings: Immunological aspects of hepatobiliary disease.

1974 • 10 citations

Electrophoretic Mobility Of Leukocyte Elastase Of Normal Subjects And Patients With Chronic Obstructive Pulmonary Disease^1,2

1977 • 8 citations

[77] Proteinase (elastase) inhibitors from the ciliated membranes of the human respiratory tract

1976 • 6 citations