Methotrexate kinetics in myeloid bone marrow cells and peripheral neutrophils

Neutrophil kinetics in man.

1976 • 545 citations

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

1977 • 390 citations

Incidence of drug-related deaths secondary to high-dose methotrexate and citrovorum factor administration.

1977 • 126 citations

Pharmacokinetic monitoring of high-dose methotrexate

1979 • 112 citations

A rapid, radiochemical-ligand binding assay for methotrexate

1976 • 106 citations

Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.

1968 • 101 citations

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro.

1984 • 100 citations

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.

1981 • 84 citations

Separation of Human Bone Marrow Cells in Density Gradients of Polyvinylpyrrolidone Coated Silica Gel (Percoll)

1980 • 77 citations

A rapid one-step method for the isolation of human granulocytes from whole blood

1982 • 75 citations

A study of the distribution of methotrexate in human tissues and tumors.

1970 • 74 citations

Mitotic Indices of Human Bone Marrow Cells. III. Duration of Some Phases of Erythrocytic and Granulocytic Proliferation Computed from Mitotic Indices

1964 • 71 citations

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow.

1985 • 70 citations

A rapid one-step method for the isolation of human granulocytes from whole blood

1982 • 60 citations

Analysis of the cytotoxic determinants for methotrexate (NSC 740): a role for 'free' intracellular drug

1975 • 42 citations

Synthesis of Methotrexate Polyglutamates by Bone Marrow Cells from Patients with Leukemia and Lymphoma

1980 • 41 citations

Granulocyte Kinetics in Health and Disease

1977 • 34 citations

Pharmacokinetics of methotrexate in erythrocytes in psoriasis

1984 • 32 citations

The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.

1974 • 29 citations

Differential effects of folinic acid and glycine, adenosine, and thymidine as rescue agents in methotrexate-treated human cells in relation to the accumulation of methotrexate polyglutamates.

1982 • 26 citations

Dipyridamole and vascular prostacyclin production

1986 • 21 citations

Separation and identification of subpicomole amounts of methotrexate polyglutamates in animal and human biopsy material

1982 • 21 citations

Methotrexate pharmacokinetics in age-fractionated erythrocytes

1986 • 20 citations

The effect of leucovorin on the synthesis of methotrexate poly-γ-glutamates in the MCF-7 human breast cancer cell line

1985 • 19 citations

Pharmacokinetics and Organ Distribution of Methotrexate in the Rat

1981 • 19 citations

Pharmacokinetics of erythrocyte methotrexate after high-dose methotrexate

1982 • 18 citations

In situ methotrexate polyglutamate formation in rat tissues.

1983 • 17 citations

Marrow cell kinetics in patients treated with methotrexate and citrovorum factor

1981 • 11 citations

The reticulocytic rat: a model for analysis of methotrexate polyglutamate dynamics in situ.

1984 • 10 citations

Differential effect of high-dose methotrexate on erythropoiesis and granulocytopoiesis in humans.

1982 • 10 citations

Report on Various Clinical Studies on High Dose Methotrexate in Europe (Non-Eortc)

1981 • 4 citations

Report on various clinical studies on high dose methotrexate in Europe (non EORTC).

1981 • 4 citations