The AF64A-Treated Rat as an Experimental Model for Alzheimer’s Disease : A Critical Evaluation

Advanced inorganic chemistry

1999 • 14,227 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Pharmacological actions of 6-hydroxydopamine.

1974 • 792 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

6-Hydroxydopamine and catecholamine neurons

1971 • 637 citations

Assessment in Geriatric Psychopharmacology

1986 • 490 citations

Presynaptic Cholinergic Dysfunction in Patients with Dementia

1983 • 422 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis

1979 • 360 citations

Mechanisms of action of 6-hydroxydopamine

1975 • 353 citations

Pre- and postsynaptic neurochemical alterations in Alzheimer's disease

1978 • 343 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine

1985 • 305 citations

Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurones: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigro-striatal dopamine system

1973 • 295 citations

THE CHOLINERGIC SYSTEM IN OLD AGE AND ALZHEIMER'S DISEASE

1980 • 237 citations

AF64A, a cholinergic neurotoxin, selectively depletes acetylcholine in hippocampus and cortex, and produces long-term passive avoidance and radial-arm maze deficits in the rat

1984 • 213 citations

Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease

1983 • 194 citations

Banbury Report 15, Biological Aspects of Alzheimer's Disease

1984 • 173 citations

Dynamics of Cholinergic Function

1986 • 161 citations

Non-specific histopathological changes induced by the intracerebral injection of 6-hydroxy-dopamine (6-OH-DA)

1972 • 149 citations

Aging of the brain

1983 • 138 citations

Sensory inattention in rats with 6-hydroxydopamine-induced degeneration of ascending dopaminergic neurons: Apomorphine-induced reversal of deficits

1979 • 135 citations

The AF64A-Treated Mouse: Possible Model for Central Cholinergic Hypofunction

1981 • 125 citations

Activity, avoidance learning and regional 5-hydroxytryptamine following intra-brain stem 5,7-dihydroxytryptamine and electrolytic midbrain raphe lesions in the rat

1976 • 122 citations

Choline analogs as potential tools in developing selective animal models of central cholinergic hypofunction

1980 • 122 citations

Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats

1984 • 116 citations

Evidence that punctate intracerebral administration of 6-hydroxydopamine fails to produce selective neuronal degeneration

1974 • 111 citations

Acetylcholine and choline levels in post-mortem human brain tissue: Preliminary observations in Alzheimer's disease

1980 • 104 citations

Cholinergic underactivity in human memory disorders

1978 • 104 citations

Ultrastructural analysis of kainic acid lesion to cerebellar cortex

1980 • 101 citations

Selective cholinergic neurotoxin: AF64A's effects in rat striatum

1984 • 86 citations

Muscarinic receptor compensation in hippocampus of Alzheimer patients

1983 • 85 citations

Intracerebroventricular administration of ethylcholine mustard aziridinium ion (AF64A) reduces release of acetylcholine from rat hippocampal slices

1985 • 78 citations

Body weight, feeding, and drinking behaviors in rats with kainic acid-induced lesions of striatal neurons—With a note on body weight symptomatology in Huntington's disease

1979 • 72 citations

Cholinergic lesion of the striatum impairs acquisition and retention of a passive avoidance response.

1984 • 61 citations

Kainic Acid: The Neurotoxic Breakthrough

1982 • 59 citations

Cholinergic lesion of the striatum impairs acquisition and retention of a passive avoidance response.

1984 • 58 citations

The use of kainic acid in the localization of enzymes in the substantia nigra

1978 • 56 citations

University of Pittsburgh

2003 • 50 citations

Degenerative processes after punctate intracerebral administration of 6-hydroxydopamine

1975 • 45 citations

Effects of intrahippocampal injections of the cholinergic neurotoxin AF64A on open-field activity and avoidance learning in the rat

1986 • 44 citations

Is there a selectivity of neuronal degeneration induced by intrastriatal injection of kainic acid?

1979 • 39 citations

Histofluorescence of kainic acid-induced striatal lesions

1978 • 36 citations

Specificity of 6-hydroxydopamine-induced destruction of mesolimbic or nigrostriatal dopamine-containing terminals

1977 • 30 citations

Effects of intrastriatal injections of the cholinergic neurotoxin AF64A on spontaneous nocturnal locomotor behavior in the rat

1984 • 29 citations

AF64A Induced Cholinotoxicity: Behavioral and Biochemical Correlates

1986 • 23 citations

Passive avoidance deficits in mice following ethylcholine aziridinium chloride treatment

1985 • 19 citations

Synaptic neurochemistry of the basal forebrain cholinergic projection.

1983 • 16 citations

Choline Availability and the Synthesis of Acetylcholine

1981 • 15 citations

Brain Lesions: Induction, Analysis, and the Problem of Recovery of Function

1978 • 14 citations

Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat

1986 • 10 citations

A Review of the Behavioral Effects of AF64A, A Cholinergic Neurotoxin

1986 • 8 citations

Histochemical and Biochemical Effects of the Injection of AF64A into The Nucleus Basalis of Meynert:Relevance to Animal Models of Senile Dementia of the Alzheimer Type

1986 • 5 citations

Neurobehavioral Aspects of Some Animal Models of Age-Related Neuropsychiatry Disorders

1986 • 4 citations

The “Autocannibalism” of Choline-Containing Membrane Phospholipids in the Pathogenesis of Alzheimer’s Disease

1986 • 3 citations

Human and Animal Studies With Cholinergic Agents: How Clinically Exploitable is the Cholinergic Deficiency in Alzheimer’s Disease

1986 • 2 citations

AF64A: A Useful Tool in Cholinergic Research

1987 • 1 citations