The binding of cyclic AMP receptor protein to two lactose promoter sites is not cooperative in vitro

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Empirical estimation of protein-induced DNA bending angles: applications to λ site-specific recombination complexes

1988 • 672 citations

The DNA binding domain and bending angle of E. coli CAP protein

1986 • 322 citations

The interaction of RNA polymerase and lac repressor with the lac control region

1979 • 283 citations

Measurement of protein‐DNA interaction parameters by electrophoresis mobility shift assay

1989 • 262 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter

1984 • 228 citations

Purification of and Properties of the Cyclic Adenosine 3',5'-Monophosphate Receptor Protein which Mediates Cyclic Adenosine 3',5'-Monophosphate-dependent Gene Transcription in Escherichia coli

1971 • 210 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

Kinetics and mechanism in the reaction of gene regulatory proteins with DNA

1984 • 181 citations

Equilibrium studies of the cyclic AMP receptor protein-DNA interaction

1984 • 178 citations

On the different binding affinities of CRP at thelac, galandmalT promoter regions

1983 • 160 citations

CAP and RNA polymerase interactions with thelacpromoter: binding stoichiometry and long range effects

1983 • 150 citations

Repressors

1976 • 132 citations

Dual promoter control of the escherichia coli lactose operon

1984 • 124 citations

Lac repressor is a transient gene-activating protein

1987 • 123 citations

Physical properties of DNA in vivo as probed by the length dependence of the lac operator looping process

1988 • 112 citations

Synergy between Escherichia coli CAP protein and RNA polymerase in the lac promoter open complex

1989 • 110 citations

Cyclic AMP receptor protein interacts with lactose operator DNA

1981 • 103 citations

Comparative gel electrophoresis measurement of the DNA bend angle induced by the catabolite activator protein

1990 • 86 citations

Influence of sequence and distance between two operators on interaction with the lac repressor.

1987 • 79 citations

Co-operative interactions between the catabolite gene activator protein and the lac repressor at the lactose promoter

1990 • 78 citations

Cooperative DNA binding of heterologous proteins: evidence for contact between the cyclic AMP receptor protein and RNA polymerase.

1988 • 78 citations

Cooperative binding to DNA of catabolite activator protein of Escherichia coli

1979 • 77 citations

Supercoiling facilitates lac operator-repressor-pseudooperator interactions.

1987 • 60 citations

Probing co-operative DNA-binding in vivo

1988 • 58 citations

Non-specific interactions of CRP from ELcoli with native and denatured DNAs: control of binding by cAMP and cGMP and by cation concentration

1979 • 55 citations

Influence of supercoiling and sequence context on operator DNA binding with lac repressor.

1987 • 54 citations

Two catabolite activator protein molecules bind to the galactose promoter region of Escherichia coli in the presence of RNA polymerase

1983 • 44 citations

DNA gelation in concentrated solutions

1984 • 42 citations

Interaction of Lac Repressor with Non-Specific DNA Binding Sites

1975 • 21 citations

A new DNA binding mode for CAP.

1990 • 21 citations

A streamlined, low ionic strength DNase I footprinting reaction.

1989 • 12 citations

Role of a second catabolite activator protein molecule in controlling initiation of transcription at the galactose operon of Escherichia coli

1986 • 9 citations