Stability and Toxicity of Hemoglobin Solutions

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

BIOCHEMISTRY OF OXYGEN TOXICITY

1989 • 1,046 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

1990 • 708 citations

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

1991 • 635 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Structure of human oxyhaemoglobin at 2·1resolution

1983 • 618 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Hemoglobin. A biologic fenton reagent.

1984 • 582 citations

Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.

1994 • 520 citations

Hemoglobin: Structure, function, evolution, and pathology

1984 • 507 citations

Hemoglobin : structure, function, evolution, and pathology

1983 • 449 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Exchange of Heme among Hemoglobins and between Hemoglobin and Albumin

1968 • 413 citations

Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?

1988 • 408 citations

Nature of the Iron–Oxygen Bond in Oxyhæmoglobin

1964 • 404 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

High-Resolution Crystal Structures of Distal Histidine Mutants of Sperm Whale Myoglobin

1993 • 386 citations

The mechanism of autooxidation of myoglobin.

1993 • 372 citations

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

1991 • 309 citations

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.

1991 • 305 citations

Brief Report: Plasma Concentrations of Hemopexin, Haptoglobin and Heme in Patients with Various Hemolytic Diseases

1968 • 303 citations

Discrimination between Oxygen and Carbon Monoxide and Inhibition of Autooxidation by Myoglobin

1989 • 292 citations

Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity

1988 • 292 citations

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1974 • 261 citations

Mechanism of autooxidation for hemoglobins and myoglobins. Promotion of superoxide production by protons and anions.

1982 • 242 citations

The physiological significance of heme oxygenase

1988 • 240 citations

Expression of fully functional tetrameric human hemoglobin in Escherichia coli.

1990 • 234 citations

Vascular heat shock protein expression in response to stress. Endocrine and autonomic regulation of this age-dependent response.

1993 • 214 citations

A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate.

1992 • 212 citations

His64(E7)–>Tyr apomyoglobin as a reagent for measuring rates of hemin dissociation.

1994 • 198 citations

His64(E7)-->Tyr apomyoglobin as a reagent for measuring rates of hemin dissociation.

1994 • 189 citations

Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32.

1993 • 177 citations

Oxidative effects of heme and porphyrins on proteins and lipids.

1989 • 143 citations

Production of unmodified human adult hemoglobin in Escherichia coli.

1993 • 142 citations

Stability of Myoglobin: A Model for the Folding of Heme Proteins

1994 • 132 citations

Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions

1995 • 122 citations

Isolation and characterization of the hemichrome-stabilized membrane protein aggregates from sickle erythrocytes. Major site of autologous antibody binding.

1988 • 118 citations

Intramolecular translocation of the protein radical formed in the reaction of recombinant sperm whale myoglobin with H2O2.

1992 • 117 citations

Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents

1991 • 117 citations

Haemoglobin and myoglobin

1981 • 108 citations

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase

1988 • 95 citations

[28] Detection, formation, and relebance of hemochromes and hemochromes

1994 • 94 citations

Formation of two hydrogen bonds from the globin to theheme-linked oxygen molecule in Ascaris hemoglobin.

1994 • 93 citations

Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.

1985 • 90 citations

Structure of hemoglobins Zürich [His E7(63)beta replaced by Arg] and Sydney [Val E11(67)beta replaced by Ala] and role of the distal residues in ligand binding.

1978 • 88 citations

Transmembrane movement of heme.

1990 • 85 citations

Molecular response to surgical stress: specific and simultaneous heat shock protein induction in the adrenal cortex, aorta, and vena cava.

1991 • 83 citations

Autoxidation of hemoglobin enhanced by dissociation into dimers.

1991 • 81 citations

Oxidative denaturation in congenital hemolytic anemias: the unstable hemoglobins.

1990 • 81 citations

Distal pocket polarity in ligand binding to myoglobin: structural and functional characterization of a threonine68 (E11) mutant

1991 • 78 citations

Human hemoglobin expression in Escherichia coli: importance of optimal codon usage

1992 • 72 citations

Oxidative modification by low levels of HOOH can transform myoglobin to an oxidase.

1991 • 72 citations

[30] Hydrogen peroxide-mediated ferrylhemoglobin generation in Vitro and in red blood cells

1994 • 69 citations

The stability of the heme-globin linkage in some normal, mutant, and chemically modified hemoglobins.

1990 • 68 citations

An exceptional amino acid replacement on the distal side of the iron atom in proboscidean myoglobin

1981 • 65 citations

Preparation and properties of the isolated α and β chains of human hemoglobin in the ferri state

1969 • 61 citations

Tin-Mediated Heme Oxygenase Gene Activation and Cytochrome P450 Arachidonate Hydroxylase Inhibition in Spontaneously Hypertensive Rats

1994 • 57 citations

Effects of Bacterial Endotoxin on Human Cross-Linked and Native Hemoglobins

1995 • 53 citations

Proton NMR study of dynamics and thermodynamics of heme rotational disorder in native and reconstituted hemoglobin A

1986 • 53 citations

Unstable Hemoglobins: The Role of Heme Loss in Heinz Body Formation

1970 • 51 citations

Transport of tetrapyrroles by proteins.

1989 • 47 citations

Nonequivalence of chains in hemoglobin oxidation and oxygen binding. Effect of organic phosphates

1974 • 46 citations

Consequences of chemical modifications on the free radical reactions of human hemoglobin

1992 • 46 citations

Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes

1993 • 43 citations

High-resolution x-ray study of deoxy recombinant human hemoglobins synthesized from .beta.-globins having mutated amino termini

1992 • 38 citations

Covalent alteration of the prosthetic heme of human hemoglobin by BrCCl3. Cross-linking of heme to cysteine residue 93.

1992 • 36 citations

Heme oxygenase does not protect human cells against oxidant stress.

1994 • 32 citations

Effect of glutaraldehyde on haemoglobin: Oxidation-reduction potentials and stability

1986 • 30 citations

Hemoglobin Warsaw (Phe beta 42(CD1)----Val), an unstable variant with decreased oxygen affinity. Characterization of its synthesis, functional properties, and structure.

1990 • 26 citations

Assessment of Hemoglobin-Dependent Neurotoxicity: Alpha-Alpha Crosslinked Hemoglobin

1994 • 25 citations

Glutaraldehyde effect on hemoglobin: evidence for an ion environment modification based on electron paramagnetic resonance and Mossbauer spectroscopies

1990 • 23 citations

Hemoglobin potentiates oxidant injury in isolated rat lungs

1991 • 20 citations

Heme oxygenase is not expressed as a stress protein after renal ischemia.

1993 • 13 citations

Subunit inequivalence in superoxide anion formation during photooxidation of human oxyhemoglobin.

1979 • 12 citations

Mutant hemoglobin stability depends upon location and nature of single point mutation

1984 • 12 citations

Non‐equivalence of Human: Hemoglobin Chains in the Oxidation‐Reduction and Heme‐Transfer Reactions

1976 • 10 citations

Dynamics of Hemoglobin Investigated by Mössbauer Spectroscopy

1984 • 10 citations

A Comparison of Rates of Heme Exchange: Site-Specifically Cross-LinkedVersusPolymerized Human Hemoglobins

1994 • 10 citations

Oxidation rates and stability in solution of mono- and bivalently cross-linked human hemoglobin

1991 • 7 citations