Septal Modulation of Hippocampal Dynamics: What Is the Function of the Theta Rhythm?

Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory.

1995 • 4,952 citations

Reactivation of Hippocampal Ensemble Memories During Sleep

1994 • 2,991 citations

Simple memory: a theory for archicortex

1971 • 2,722 citations

Phase relationship between hippocampal place units and the EEG theta rhythm

1993 • 2,517 citations

Dynamics of the Hippocampal Ensemble Code for Space

1993 • 2,329 citations

Two-stage model of memory trace formation: A role for “noisy” brain states

1989 • 1,677 citations

Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences

1996 • 1,652 citations

HIPPOCAMPAL ELECTRICAL ACTIVITY IN AROUSAL

1954 • 1,379 citations

Hippocampal synaptic enhancement and information storage within a distributed memory system

1987 • 1,291 citations

GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus

1988 • 1,247 citations

The Hippocampo-Neocortical Dialogue

1996 • 908 citations

Hippocampal sharp waves: Their origin and significance

1986 • 908 citations

Spatial firing patterns of hippocampal complex-spike cells in a fixed environment

1987 • 895 citations

The hippocampus—what does it do?

1992 • 872 citations

Loss of Hippocampal Theta Rhythm Results in Spatial Memory Deficit in the Rat

1978 • 849 citations

Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

1984 • 748 citations

Discussion

1997 • 717 citations

A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances

1991 • 715 citations

Local and diffuse synaptic actions of GABA in the hippocampus

1993 • 709 citations

Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: A combined light and electron microscopic study

1985 • 594 citations

Heightened synaptic plasticity of hippocampal CA1 neurons during a Cholinergically induced rhythmic state

1993 • 571 citations

Do septal neurons pace the hippocampal theta rhythm?

1990 • 568 citations

Neuromodulation and cortical function: modeling the physiological basis of behavior

1995 • 554 citations

The hippocampus as an associator of discontiguous events

1998 • 526 citations

Hippocampal theta activity following selective lesion of the septal cholinergic systeM

1994 • 505 citations

Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats

1995 • 470 citations

Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3

1995 • 469 citations

Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology

1994 • 455 citations

Septal neurons containing glutamic acid decarboxylase immunoreactivity project to the hippocampal region in the rat brain

1984 • 438 citations

Acetylcholine and memory

1993 • 421 citations

A sequence predicting CA3 is a flexible associator that learns and uses context to solve hippocampal-like tasks

1996 • 403 citations

Hippocampal CA3 region predicts memory sequences: accounting for the phase precession of place cells.

1996 • 392 citations

Acetylcholine Activates an α-Bungarotoxin-Sensitive Nicotinic Current in Rat Hippocampal Interneurons, But Not Pyramidal Cells

1998 • 380 citations

Encoding and retrieval of episodic memories: Role of cholinergic and GABAergic modulation in the hippocampus

1998 • 377 citations

Cue-sampling and goal-approach correlates of hippocampal unit activity in rats performing an odor-discrimination task

1987 • 376 citations

Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum.

1997 • 374 citations

Population dynamics and theta rhythm phase precession of hippocampal place cell firing: A spiking neuron model

1998 • 366 citations

Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat

1994 • 359 citations

Presynaptic inhibitory effect of acetylcholine in the hippocampus

1981 • 342 citations

Extrinsic and intrinsic properties underlying oscillation and synchrony in limbic cortex

1993 • 331 citations

Facilitation of the Induction of Long-term Potentiation by GABA _B Receptors

1991 • 330 citations

Cues that hippocampal place cells encode: Dynamic and hierarchical representation of local and distal stimuli

1997 • 319 citations

Model of the Origin of Rhythmic Population Oscillations in the Hippocampal Slice

1989 • 318 citations

Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function

1997 • 316 citations

Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat.

1982 • 301 citations

GABAergic Modulation of Hippocampal Population Activity: Sequence Learning, Place Field Development, and the Phase Precession Effect

1997 • 300 citations

Cholinergic excitation of GABAergic interneurons in the rat hippocampal slice.

1992 • 291 citations

Functional Significance of Long-Term Potentiation for Sequence Learning and Prediction

1996 • 281 citations

Temporal relationship between sniffing and the limbic theta rhythm during odor discrimination reversal learning

1982 • 270 citations

Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats

1986 • 247 citations

Ionic mechanisms of cholinergic excitation in mammalian hippocampal pyramidal cells

1982 • 245 citations

Characterization of synaptically elicited GABAB responses using patch‐clamp recordings in rat hippocampal slices.

1993 • 241 citations

Preserved spatial coding in hippocampal CA1 pyramidal cells during reversible suppression of CA3c output: evidence for pattern completion in hippocampus

1989 • 224 citations

Presynaptic inhibitory action of acetylcholine in area CA1 of the hippocampus

1978 • 223 citations

INTRACELLULAR RECORDS FROM HIPPOCAMPAL PYRAMIDAL CELLS IN RABBIT DURING THETA RHYTHM ACTIVITY

1964 • 217 citations

Neuronal sources of theta rhythm in the entorhinal cortex of the rat

1987 • 211 citations

The rhythmicity of cells of the medial septum/diagonal band of Broca in the awake freely moving rat: relationships with behaviour and hippocampal theta

1998 • 191 citations

Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus

1990 • 191 citations

Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus

1990 • 187 citations

Evidence for Differential Control of Posterior Hypothalamic, Supramammillary, and Medial Mammillary Theta-Related Cellular Discharge by Ascending and Descending Pathways

1996 • 186 citations

A novel cholinergic induction of long-term potentiation in rat hippocampus

1994 • 164 citations

Cholinergic modulation of synaptic inhibition in the guinea pig hippocampus in vitro: excitation of GABAergic interneurons and inhibition of GABA-release

1993 • 161 citations

Baclofen selectively inhibits excitatory synaptic transmission in the hippocampus

1981 • 161 citations

Electrophysiological and pharmacological characterization of perforant path synapses in CA1: mediation by glutamate receptors

1992 • 161 citations

Mechanism and Kinetics of Heterosynaptic Depression at a Cerebellar Synapse

1997 • 145 citations

Baclofen selectively inhibits transmission at synapses made by axons of CA3 pyramidal cells in the hippocampal slice.

1982 • 141 citations

Changes in neuronal transmission in the rat hippocampus during behavior

1981 • 132 citations

Frequency Modulation of Hippocampal Theta by the Supramammillary Nucleus, and Other Hypothalamo–Hippocampal Interactions: Mechanisms and Functional Implications

1998 • 126 citations

Enhanced acetylcholine release in the hippocampus and cortex during acquisition of an operant behavior

1996 • 124 citations

Phase relations of hippocampal projection cells and interneurons to theta activity in the anesthetized rat

1983 • 124 citations

Alterations in acetylcholine release in the rat hippocampus during sleep-wakefulness detected by intracerebral dialysis

1990 • 123 citations

Hippocampal excitability phase-locked to the theta rhythm in walking rats

1980 • 121 citations

Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro

1994 • 116 citations

Presynaptic action of acetylcholine in thin sections from the guinea pig dentate gyrus in vitro

1967 • 116 citations

Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus.

1996 • 114 citations

Hippocampal theta activity in monkeys

1991 • 106 citations

Acetylcholine and Learning in a Cortical Associative Memory

1993 • 103 citations

Membrane potential and impedance changes in hippocampal pyramidal cells during theta rhythm

1989 • 100 citations

Intracellular recordings from medial septal neurons during hippocampal theta rhythm

1997 • 96 citations

Galanin in the medial septal area impairs working memory

1992 • 91 citations

Reversible inactivation of the medial septum: selective effects on the spontaneous unit activity of different hippocampal cell types

1989 • 88 citations

Carbachol depresses synaptic responses in the medial but not the lateral perforant path

1989 • 81 citations

Exploration-dependent modulation of evoked responses in fascia dentata: dissociation of motor, EEG, and sensory factors and evidence for a synaptic efficacy change

1990 • 79 citations

Pharmacology of the dendritic action of acetylcholine and further observations on the somatic disinhibition in the rat hippocampusin situ

1983 • 78 citations

Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade

1996 • 78 citations

The classification of medial septum-diagonal band cells as σ-on or σ-off in relation to hippocampal EEG states

1989 • 74 citations

Phase relations of rhythmic neuronal firing in the supramammillary nucleus and mammillary body to the hippocampal theta activity in urethane anesthetized rats

1997 • 74 citations

The effects of selective septal lesions on theta production in CA1 and the dentate gyrus of the hippocampus

1981 • 73 citations

Firing relations of medial entorhinal neurons to the hippocampal theta rhythm in urethane anesthetized and walking rats

1992 • 69 citations

Selective suppression of intrinsic but not afferent fiber synaptic transmission by baclofen in the piriform (olfactory) cortex

1994 • 66 citations

Suppression of synaptic transmission may allow combination of associative feedback and self-organizing feedforward connections in the neocortex

1996 • 64 citations

Stimulation parameters determine role of GABAB receptors in long-term potentiation

1993 • 63 citations

Intraseptal Microinfusion of Muscimol: Effects on Hippocampal Formation Theta Field Activity and Phasic Theta-ON Cell Discharges

1996 • 60 citations

Sensory modulation of hippocampal transmission. II. Evidence for a cholinergic locus of inhibition in the Schaffer-CA1 synapse

1988 • 52 citations

Effects of lesions in the horizontal diagonal band nucleus on olfactory habituation in the rat

1993 • 49 citations

Sensory modulation of hippocampal transmission. I. Opposite effects on CA1 and dentate gyrus synapsis

1988 • 49 citations

Effects of baclofen on synaptically‐induced cell firing in the rat hippocampal slice

1983 • 46 citations

GABAB modulation improves sequence disambiguation in computational models of hippocampal region CA3

1998 • 46 citations

Effects of cholinergic agonists on two non-pyramidal cell types in rat hippocampal slices

1991 • 37 citations

Effects of medial septal lesions on operant delayed alternation in rats

1990 • 37 citations

Functional Transitions Between Epileptiform-Like Activity and Associative Memory in Hippocampal Region CA3

1997 • 36 citations

Changes in GABA_BModulation During a Theta Cycle May Be Analogous to the Fall of Temperature During Annealing

1998 • 34 citations

Hippocampal excitability related to the phase of the theta rhythm in urethanized rats

1984 • 22 citations

Learning sets, discrimination reversal, and hippocampal function

1986 • 22 citations

Effects of medial septal lesions on an operant go/no-go delayed response alternation task in rats

1995 • 14 citations