Interleukin 2 rapidly stimulates synthesis and breakdown of polyphosphoinositides in interleukin 2-dependent, murine T-cell lines.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

1976 • 2,458 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

The polyphosphoinositide phosphodiesterase of erythrocyte membranes

1981 • 614 citations

Transient expression of interleukin 2 receptors. Consequences for T cell growth.

1983 • 613 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

Thymoma production of T cell growth factor (Interleukin 2).

1980 • 487 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation.

1982 • 240 citations

Activation of Na+/H+ exchange by epidermal growth factor elevates intracellular pH in A431 cells.

1983 • 230 citations

Mitogens increase phosphorylation of phosphoinositides in thymocytes

1984 • 223 citations

Unidimensional thin-layer chromatography of phospholipids on boric acid-impregnated plates.

1982 • 202 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

T‐CELL GROWTH FACTOR‐MEDIATED T‐CELL PROLIFERATION*

1979 • 168 citations

Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

1983 • 145 citations

Studies on the mechanism by which phytohemagglutinin rapidly stimulates phospholipid metabolism of human lymphocytes

1971 • 144 citations

Differential activation of phosphatidylinositol deacylation and a pathway via diphosphoinositide in macrophages responding to zymosan and ionophore A23187.

1984 • 123 citations

Inositol lipid metabolism in dividing and differentiating cells

1982 • 119 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Effects of various mitogens on the phospholipid metabolism of human peripheral lymphocytes

1973 • 70 citations

The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin

1985 • 66 citations

Leukocytes and host defense

1987 • 62 citations

Monoclonal antibody to SV40 T-antigen blocks lysis of cloned cytotoxic T-cell line specific for SV40 TASA

1983 • 52 citations

Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells.

1984 • 46 citations

Production of immune interferon by an interleukin 2-independent murine T cell line.

1982 • 43 citations

Phorbol myristate acetate and in vitro T lymphocyte function. I. PMA may contaminate lymphokine preparations and can interfere with interleukin bioassays.

1983 • 37 citations