Utilization of signal transduction pathway by the human T-cell leukemia virus type I transcriptional activator tax

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Trans -Acting Transcriptional Activation of the Long Terminal Repeat of Human T Lymphotropic Viruses in Infected Cells

1984 • 781 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.

1988 • 736 citations

Human T-lymphotropic retroviruses

1985 • 623 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

ADENOVIRUS PROMOTERS AND E1A TRANSACTIVATION

1986 • 460 citations

Activation of the HIV-1 LTR by T Cell Mitogens and the Trans-Activator Protein of HTLV-I

1987 • 460 citations

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.

1988 • 361 citations

A Transcriptional Activator Protein Encoded by the x- lor Region of the Human T-Cell Leukemia Virus

1985 • 346 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

c-fos Sequence Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate and the Calcium Ionophore

1987 • 304 citations

Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.

1988 • 290 citations

A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.

1987 • 284 citations

A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1.

1988 • 259 citations

Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis

1988 • 257 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

1986 • 212 citations

A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro.

1987 • 208 citations

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins.

1988 • 198 citations

Identification of factors that interact with the E1A-inducible adenovirus E3 promoter.

1987 • 189 citations

Amplification and Molecular Cloning of HTLV-I Sequences from DNA of Multiple Sclerosis Patients

1989 • 184 citations

Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer.

1986 • 175 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

T-Cell Activation Signals and Human T-Cell Leukemia Virus Type I-Encoded p40^x Protein Activate the Mouse Granulocyte-Macrophage Colony-Stimulating Factor Gene Through a Common DNA Element

1988 • 171 citations

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

1988 • 148 citations

Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.

1988 • 137 citations

Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.

1988 • 128 citations

Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor.

1988 • 120 citations

Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40^xprotein and bovine papilloma virus encoded E2 protein

1988 • 115 citations

Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression.

1988 • 107 citations

Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeat.

1989 • 81 citations

Functional Relation Between HTLV-II x and Adenovirus E1A Proteins in Transcriptional Activation

1985 • 75 citations

Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression.

1987 • 69 citations

Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene.

1988 • 67 citations

EivF, a factor required for transcription of the adenovirus EIV promoter, binds to an element involved in EIa-dependent activation and cAMP induction.

1988 • 67 citations

cAMP acts in synergy with E1A protein to activate transcription of the adenovirus early genes E4 and E1A.

1988 • 66 citations

Nucleotide sequence analysis of a provirus derived from HTLV-1-associated myelopathy (HAM).

1988 • 64 citations

Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element

1988 • 63 citations

Viral Aetiology of Adult T-Cell Leukaemia

1985 • 62 citations

Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns

1988 • 57 citations

Promoter trans-activation of protooncogenes c-fos and c-myc, but not c-Ha-ras, by products of adenovirus early region 1A.

1987 • 52 citations

Purification and Characterization of Multiple Nuclear Factors That Bind to the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1989 • 38 citations

Molecular cloning of human T-cell lymphotrophic virus type I-like proviral genome from the peripheral lymphocyte DNA of a patient with chronic neurologic disorders.

1988 • 32 citations

Purification and functional characterization of a cellular transcription factor that binds to an enhancer element within the adenovirus early EIIa promoter.

1988 • 31 citations

Three Sequence-Specific DNA-Protein Complexes Are Formed with the Same Promoter Element Essential for Expression of the Rat Somatostatin Gene

1988 • 23 citations

Evidence for a cAMP-dependent nuclear factor capable of interacting with a specific region of a eukaryotic gene.

1988 • 17 citations

A novel enhancement of SV40 enhancer activity by treatment of mouse neuroblastoma N18TG2 with protein kinase inhibitor H-7

1988 • 1 citations