Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

1979 • 975 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 715 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression

1979 • 476 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.

1982 • 410 citations

Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1979 • 378 citations

Mechanisms of Calcium Antagonist-Induced Vasodilation

1983 • 370 citations

Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin

1983 • 366 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Phospholipid degradation and signal translation for protein phosphorylation

1983 • 323 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Epidermal growth factor and thyrotropin-releasing hormone act similarly on a clonal pituitary cell strain. Modulation of hormone production and inhibition of cell proliferation

1980 • 226 citations

Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists.

1983 • 219 citations

Functionally Differentiated Cell Lines

1982 • 213 citations

Epidermal growth factor rapidly stimulates prolactin gene transcription

1982 • 208 citations

Thyrotropin-releasing hormone stimulates rapid loss of phosphatidylinositol and its conversion to 1,2-diacylglycerol and phosphatidic acid in rat mammotropic pituitary cells. Association with calcium mobilization and prolactin secretion.

1983 • 181 citations

Distinct patterns of cytoplasmic protein phosphorylation related to regulation of synthesis and release of prolactin by GH cells.

1983 • 172 citations

Polypeptide hormone regulation of gene expression. Thyrotropin-releasing hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein.

1983 • 164 citations

Action potentials occur in cells of the normal anterior pituitary gland and are stimulated by the hypophysiotropic peptide thyrotropin-releasing hormone.

1977 • 161 citations

Membrane potential changes caused by thyrotropin-releasing hormone in the clonal GH3 cell and their relationship to secretion of pituitary hormone.

1979 • 137 citations

Biochemical Actions of Hormones

1978 • 135 citations

CALCIUM INFLUX IS NOT REQUIRED FOR TRH TO ELEVATE FREE CYTOPLASMIC CALCIUM IN GH₃CELLS

1983 • 133 citations

Functionally Differentiated Cell Lines

1982 • 123 citations

Role of calcium in the thyrotropin-releasing hormone-stimulated release of prolactin from pituitary cells in culture

1978 • 117 citations

Calcium specifically stimulates prolactin synthesis and messenger RNA sequences in GH3 cells.

1981 • 117 citations

Thyrotropin-releasing hormone rapidly activates protein phosphorylation in GH3 pituitary cells by a lipid-linked, protein kinase C-mediated pathway.

1984 • 115 citations

Receptor-mediated release of plasma membrane-associated calcium and stimulation of calcium uptake by thyrotropin-releasing hormone in pituitary cells in culture.

1981 • 113 citations

Phosphoinositide Metabolism and Hormone Action*

1983 • 111 citations

Inhibition of Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone Release by Pimozide: Evidence for a Site of Action after Calcium Mobilization*

1981 • 105 citations

Thyrotropin-Releasing Hormone (TRH) Selectively and Rapidly Stimulates Phosphatidylinositol Turnover in GH Pituitary Cells: A Possible Second Step of TRH Action*

1982 • 105 citations

Bombesin Stimulates Prolactin and Growth Hormone Release by Pituitary Cells in Culture*

1982 • 104 citations

Thyrotropin-releasing hormone rapidly and transiently stimulates cytosolic calcium-dependent protein phosphorylation in GH3 pituitary cells.

1982 • 102 citations

Voltage-dependent calcium channels in pituitary cells in culture. I. Characterization by 45Ca2+ fluxes.

1984 • 101 citations

Tumor-Promoting Phorbol Esters Affect Production of Prolactin and Growth Hormone by Rat Pituitary Cells*

1981 • 98 citations

Voltage-dependent calcium channels in pituitary cells in culture. II. Participation in thyrotropin-releasing hormone action on prolactin release.

1984 • 97 citations

Thyrotropin-releasing hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript.

1981 • 82 citations

Polypeptide hormone regulation of gene transcription: specific 5' genomic sequences are required for epidermal growth factor and phorbol ester regulation of prolactin gene expression.

1984 • 73 citations

Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

1982 • 71 citations

Thyrotropin-releasing hormone and cyclic AMP activate distinctive pathways of protein phosphorylation in GH pituitary cells.

1982 • 64 citations

Effects of thyroliberin and 4‐aminopyridine on action potentials and prolactin release and synthesis in rat pituitary cells in culture

1980 • 54 citations

TETRACAIME, PROPRANOLOL AND TRIFLUOPERAZINE INHIBIT THYROTROPIN RELEASING HORMONE-INDUCED PROLACTIN SECRETION FROM GH³CELLS BY DISPLACING MEMBRANE CALCIUM: FURTHER EVIDENCE THAT TRH ACTS TO MOBILIZE CELLULAR CALCIUM

1982 • 27 citations

Thyrotropin-releasing hormone modulation of uridine uptake in rat pituitary cells. Characterization of the responses.

1978 • 18 citations