In vivo clearance of low density lipoprotein in pigeons occurs by a receptor-like mechanism that is not down-regulated by cholesterol feeding.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITY

1952 • 3,146 citations

Rapid analysis of amino acids using pre-column derivatization

1984 • 2,491 citations

LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis

1983 • 2,306 citations

Determination of free amino groups in proteins by trinitrobenzenesulfonic acid

1966 • 2,029 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Electrophoretic separation of plasma lipoproteins in agarose gel

1968 • 1,332 citations

The Theory of Tracer Experiments with ¹³¹I-Labelled Plasma Proteins

1957 • 834 citations

The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia

1972 • 629 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.

1985 • 519 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

1984 • 393 citations

Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster.

1988 • 364 citations

Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.

1985 • 318 citations

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.

1981 • 318 citations

A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo

1983 • 317 citations

Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo.

1981 • 278 citations

Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.

1983 • 230 citations

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

1987 • 220 citations

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells.

1985 • 219 citations

Metabolic Studies in Familial Hypercholesterolemia

1979 • 217 citations

Rates of low density lipoprotein uptake and cholesterol synthesis are regulated independently in the liver.

1985 • 206 citations

Receptor-mediated Catabolism of Low Density Lipoprotein in Man. QUANTITATION USING GLUCOSYLATED LOW DENSITY LIPOPROTEIN

1983 • 202 citations

Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits.

1982 • 201 citations

Lipoprotein Kinetics and Modeling

1982 • 201 citations

5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription

1985 • 187 citations

cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.

1983 • 168 citations

Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia

1982 • 143 citations

Uptake of canine beta-very low density lipoproteins by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor.

1986 • 123 citations

Inhibition of receptor-mediated clearance of lysine and arginine modified lipoproteins from the plasma of rats and monkeys

1980 • 120 citations

Correlation of low and high density lipoprotein binding in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin.

1982 • 118 citations

Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats

1981 • 118 citations

Receptor-independent low density lipoprotein transport in the rat in vivo. Quantitation, characterization, and metabolic consequences.

1985 • 116 citations

Tissue sites of degradation of native and reductively methylated [14C]sucrose-labeled low density lipoprotein in rats. Contribution of receptor-dependent and receptor-independent pathways.

1982 • 110 citations

Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity

1987 • 109 citations

Cholesterol feeding increases low density lipoprotein synthesis.

1983 • 108 citations

LDL, scavenger, and beta-VLDL receptors on aortic endothelial cells.

1984 • 98 citations

Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium.

1983 • 79 citations

Characterization of plasma lipoproteins of grain- and cholesterol-fed White Carneau and Show Racer pigeons.

1985 • 79 citations

Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism.

1983 • 77 citations

Chicken Oocytes and Fibroblasts Express Different Apolipoproteins-B-Specific Receptors

1989 • 73 citations

Composition and concentration of apolipoproteins in very-low-and low-density lipoproteins of normal human plasma.

1974 • 68 citations

Stimulation of cholesterol esterification in rhesus monkey arterial smooth muscle cells.

1977 • 62 citations

Quantitative role of parenchymal and non-parenchymal liver cells in the uptake of [14C]sucrose-labelled low-density lipoprotein in vivo

1984 • 56 citations

Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man.

1986 • 46 citations

Impaired receptor-mediated catabolism of low density lipoproteins in fasted rabbits.

1984 • 38 citations

Contribution of the receptor pathway to low density lipoprotein catabolism in humans. New methods for quantitation.

1984 • 34 citations

Relationship of plasma lipoproteins and the monocyte-macrophage system to atherosclerosis severity in cholesterol-fed pigeons.

1986 • 34 citations

Low density lipoprotein receptor binding in aging human diploid fibroblasts in culture.

1982 • 34 citations

Receptor-mediated catabolism and tissue uptake of human low density lipoprotein in the cholesterol-fed, atherosclerotic rabbit

1982 • 31 citations

Pigeon aortic smooth muscle cells lack a functional low density lipoprotein receptor pathway.

1984 • 26 citations

Lipoprotein metabolism by macrophages from atherosclerosis-susceptible White Carneau and resistant Show Racer pigeons.

1988 • 23 citations

Cholesterol metabolism in pigeon aortic smooth muscle cells lacking a functional low density lipoprotein receptor pathway.

1984 • 22 citations

Cycloheximide inhibits sterol biosynthesis in cell-free preparations of rat liver.

1980 • 19 citations

Biochemical and immunological evidence for the presence of an apolipoprotein b-like component in the serum low-density lipoproteins of several animal species

1977 • 18 citations

Metabolism of low density lipoproteins by pigeon skin fibroblasts and aortic smooth muscle cells. Comparison of cells from atherosclerosis-susceptible and atherosclerosis-resistant pigeons.

1986 • 14 citations

Metabolism of [I]tyramine cellobiose-labeled low density lipoproteins in squirrel monkeys

1985 • 9 citations