Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

1969 • 775 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution

1987 • 478 citations

Staphylococcal nuclease: Proposed mechanism of action based on structure of enzyme—thymidine 3′,5′-bisphosphate—calcium ion complex at 1.5-Å resolution

1979 • 375 citations

Bond Order and Charge Localization in Nucleoside Phosphorothioates

1985 • 277 citations

The crystal structure of the ternary complex of staphylococcal nuclease, Ca²⁺ and the inhibitor pdTp, refined at 1.65 Å

1989 • 258 citations

Amino acid sequence of the regulatory subunit of bovine type I cAMP-dependent protein kinase

1984 • 253 citations

Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.

1987 • 248 citations

Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP.

1982 • 229 citations

Structural comparisons of cAMP-dependent protein kinases I and II from porcine skeletal muscle

1979 • 221 citations

Theory of molecular interactions

1986 • 191 citations

Two different intrachain cAMP binding sites of cAMP-dependent protein kinases.

1980 • 189 citations

[15] cAMP analog antagonists of cAMP action

1988 • 184 citations

Competitive cAMP antagonists for cAMP-receptor proteins.

1984 • 174 citations

Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase

1987 • 151 citations

Comparison of the two classes of binding sites (A and B) of type I and type II cyclic‐AMP‐dependent protein kinases by using cyclic nucleotide analogs

1989 • 144 citations

Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP‐dependent protein kinases

1984 • 131 citations

Amino acid sequence of the regulatory subunit of bovine type II cAMP-dependent protein kinase

1984 • 128 citations

Activation of protein kinase isozymes by cyclic nucleotide analogs used singly or in combination

1985 • 115 citations

An equilibrium study of the cooperative binding of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate to the adenosine cyclic 3',5'-monophosphate receptor protein from Escherichia coli

1980 • 112 citations

Interaction of cAMP Derivatives with the ‘Stable’ CAMP‐Binding Site in the CAMP‐Dependent Protein Kinase Type I

1982 • 111 citations

Inhibition of glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3‘,5‘-phosphorothioate.

1983 • 111 citations

Evidence that rabbit muscle protein kinase has two kinetically distinct binding sites for adenosine 3′; 5′-cyclic monophosphate

1978 • 98 citations

A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase.

1988 • 91 citations

Stereospecific synthesis of adenosine 3′,5′-(S_P)- and -(R_P)-cyclic phosphorothioates (cAMPS)

1979 • 84 citations

Expression and Characterization of Mutant Forms of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase

1989 • 78 citations

Studies on the function of the two intrachain cAMP binding sites of protein kinase.

1981 • 73 citations

A Model for the Chemical Interactions of Adenosine 3':5'-Monophosphate with the R Subunit of Protein Kinase Type I. Refinement of the Cyclic Phosphate Binding moiety of Protein Kinase Type I

1979 • 70 citations

Characterization of the interchain and intrachain interactions between the binding sites of the free regulatory moiety of protein kinase I.

1984 • 64 citations

Structure of bis(methylguanidinium) monohydrogen orthophosphate. Model for the arginine-phosphate interactions at the active site of staphylococcal nuclease and other phosphohydrolytic enzymes

1974 • 64 citations

Mapping of the two intrachain cyclic nucleotide binding sites of adenosine cyclic 3',5'-phosphate dependent protein kinase I

1983 • 61 citations

Sulfur does not form double bonds in phosphorothioate anions

1987 • 55 citations

Mutations that prevent cyclic nucleotide binding to binding sites A or B of type I cyclic AMP-dependent protein kinase.

1988 • 51 citations

A kinetic study of interactions of (RP)- and (SP)-adenosine cyclic 3',5'-phosphorothioates with type II bovine cardiac muscle adenosine cyclic 3',5'-phosphate dependent protein kinase

1982 • 46 citations

Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues

1984 • 43 citations

Protein kinase II has two distinct binding sites for cyclic AMP, only one of which is detectable by the conventional membrane‐filtration method

1980 • 42 citations

Activation of type I cyclic AMP-dependent protein kinases with defective cyclic AMP-binding sites.

1987 • 39 citations

Synthesis of nucleoside-3', 5'-cyclic phosphorothioates by cyclothiophosphorylation of unprotected nucleosides

1988 • 34 citations

Inhibition of cAMP-dependent protein kinase by adenosine cyclic 3‘-, 5‘-phosphorodithioate, a second cAMP antagonist.

1988 • 33 citations

Effect of ion pairing on bond order and charge localization in alkyl phosphorothioates

1988 • 33 citations

Phosphorus-oxygen bond order in adenosine 5'-O-phosphorothioate dianion

1984 • 31 citations

Synthesis of the 3′,5′-Cyclic Phosphates from Unprotected Nucleosides

1989 • 25 citations

Phosphorus-sulfur bond order in phosphothioate anions

1986 • 14 citations

Crystal Structure of Propylguanidinium Diethyl Phosphate.

1972 • 13 citations

Absolute configuration ofRp-uridine 3′,5′-cyclic phosphorothioate

1987 • 8 citations

Stereospecific Synthesis and Assignment of Absolute Configuration at Phosphorus in Nucleoside 3′- and 5′-O-Arylphosphorothioates and Nucleoside Cyclic 3′,5′-Phosphorothioates

1981 • 3 citations

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