A 2.2-kilobase repeated DNA segment is associated with DNA amplification in Streptomyces fradiae

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Experiments in molecular genetics

1972 • 28,260 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

SUPERCOILED CIRCULAR DNA-PROTEIN COMPLEX IN Escherichia coli : PURIFICATION AND INDUCED CONVERSION TO AN OPEN CIRCULAR DNA FORM

1969 • 1,847 citations

A colony bank containing synthetic CoI EI hybrid plasmids representative of the entire E. coli genome

1976 • 1,313 citations

A simple method for DNA restriction site mapping

1976 • 1,025 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

DNA Restriction Enzyme from E. coli

1968 • 816 citations

Construction and characterization of new cloning vehicles III. Derivatives of plasmid pBR322 carrying unique Eco RI sites for selection of Eco RI generated recombinant DNA molecules

1978 • 752 citations

Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures

1975 • 411 citations

In vitro packaging of a λ Dam vector containing EcoRI DNA fragments of Escherichia coli and phage P1

1977 • 319 citations

Transformation in Escherichia coli: cryogenic preservation of competent cells

1977 • 242 citations

Nucleic acid spot hybridization: rapid quantitative screening of lymphoid cell lines for Epstein-Barr viral DNA.

1980 • 211 citations

Genetic Recombination in Streptomyces fradiae by Protoplast Fusion and Cell Regeneration

1978 • 153 citations

Amplified DNA in Streptomyces fradiae

1983 • 95 citations

Chromosomal locations of the genes for rRNA in Escherichia coli K-12.

1982 • 92 citations

Representation of DNA sequences in recombinant DNA libraries prepared by restriction enzyme partial digestion

1982 • 90 citations

Estimate of the Genome Size by Renaturation Studies in Streptomyces

1975 • 69 citations

Deletion and amplification of DNA sequences in melanin-negative variants of Streptomyces reticuli

1983 • 68 citations

Plasmid loss and changes within the chromosomal DNA of Streptomyces reticuli

1982 • 62 citations

Occurence of reiterated DNA sequences in strains of Streptomyces produced by an interspecific protoplast fusion

1981 • 58 citations

Reiterated DNA sequences in a mutant strain of Streptomyces glaucescens and cloning of the sequence in Escherichia coli

1982 • 45 citations

Selective retention of recombinant plasmids coding for human insulin

1983 • 37 citations

Homologous sequences other than insertion elements can serve as recombination sites in plasmid drug resistance gene amplification

1983 • 33 citations

[Multiplication of a DNA fragment in Streptomyces antibioticus--producer of oleandomycin].

1983 • 13 citations

Role of plasmids in producers of macrolides

1982 • 12 citations

Theoretical study of the fraction of a long‐chain DNA that can be incorporated in a recombinant DNA partial‐digest library

1982 • 9 citations

Optimization of conditions for the in vitro formation of hybrid DNA molecules by DNA ligase

1979 • 4 citations