Adverse Effects of Antituberculosis Drugs

Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable Pathogenesis

1976 • 513 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

THE OCULAR TOXICITY OF ETHAMBUTOL AND ITS RELATION TO DOSE*

1966 • 234 citations

Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.

1954 • 231 citations

B-Complex Vitamins in Liver Disease of the Alcoholic

1965 • 215 citations

Potentially Serious Side Effects of High-dose Twice-weekly Rifampicin

1971 • 214 citations

The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide

1977 • 193 citations

Effect of Isoniazid on Vitamin B6 Metabolism; Its Possible Significance in Producing Isoniazid Neuritis.

1954 • 186 citations

Pyridoxine supplementation during isoniazid therapy

1980 • 170 citations

Isoniazid Hepatitis

1973 • 162 citations

Peripheral neuritis due to isoniazid.

1960 • 149 citations

Adverse reactions to rifampicin in antituberculosis regimens

1977 • 136 citations

Clinical Spectrum of Hemolytic Anemia Associated with Glucose-6-Phosphate Dehydrogenase Deficiency

1966 • 134 citations

Rifampicin-induced Immune Thrombocytopenia

1970 • 133 citations

Adverse Reactions to Daily and Intermittent Rifampicin Regimens for Pulmonary Tuberculosis in Hong Kong

1972 • 130 citations

Hearing Loss in Infants of Tuberculous Mothers Treated with Streptomycin during Pregnancy

1964 • 118 citations

Chemical and Biological Properties of Rifampicin

2015 • 89 citations

Comparative trial of isoniazid in combination with thiacetazone or a substituted diphenylthiourea (SU1906) or PAS in the treatment of acute pulmonary tuberculosis in east africans

1960 • 85 citations

Vitamin B6 deficiency in chronic liver disease--evidence for increased degradation of pyridoxal-5'-phosphate.

1977 • 81 citations

Effect of Pyrazinamide and Pyrazinoic Acid on Urate Clearance and Other Discrete Renal Functions.

1957 • 80 citations

Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapy

1971 • 77 citations

Pyrazinamide-isoniazid in tuberculosis.

1954 • 76 citations

Controlled trial of four thrice-weekly regimens and a daily regimen all given for 6 months for pulmonary tuberculosis.

1981 • 74 citations

Effect of Rifampicin and Isoniazid on Liver Function

1972 • 74 citations

ACUTE RENAL FAILURE AFTER RIFAMPICIN

1972 • 62 citations

Co-operative controlled trial of a standard regimen of streptomycin,pas and isoniazid and three alternative regimens of chemotherapy in Britain A report from the British Medical Research Council

1973 • 62 citations

Hyperuricemia Due to Ethambutol

1972 • 61 citations

The role of diet in the treatment of pulmonary tuberculosis. An evaluation in a controlled chemotherapy study in home and sanatorium patients in South India.

1961 • 60 citations

Isoniazid with thiacetazone in the treatment of pulmonary tuberculosis in East Africa—Second investigationCo-operative Studies in East African Hospitals and Laboratòries with the Collaboration of the East African and British Medical Research Councils

1963 • 57 citations

A controlled comparison of a twice-weekly and three once-weekly regimens in the initial treatment of pulmonary tuberculosis.

1970 • 55 citations

The rifampicins in purulent bronchitis

1969 • 54 citations

Rifampin in initial treatment of pulmonary tuberculosis. A.U.S. Public Health Service tuberculosis therapy trial.

1974 • 53 citations

Rifampin in Initial Treatment of Pulmonary Tuberculosis

2015 • 53 citations

The current status of short-course chemotherapy

1979 • 53 citations

Iatrogenic deafness

1970 • 53 citations

POSSIBLE INDUCTION OF ANTINUCLEAR ANTIBODIES BY ISONIAZID

1966 • 52 citations

Hepatitis cases in isoniazid treated groups and in a control group.

1976 • 49 citations

The Formation of Pyridoxal and Pyridoxal 5-Phosphate Hydrazones¹

1956 • 46 citations

THE PREVENTION AND TREATMENT OF ISONIAZID TOXICITY IN THE THERAPY OF PULMONARY TUBERCULOSIS. 2. AN ASSESSMENT OF THE PROPHYLACTIC EFFECT OF PYRIDOXINE IN LOW DOSAGE.

1963 • 45 citations

A controlled clinical trial of daily and intermittent regimens of rifampicin plus ethambutol in the retreatment of patients with pulmonary tuberculosis in Hong Kong A Hong Kong tuberculosis treatment services/Brompton hospital/British medical research council investigation

1974 • 44 citations

Interaction of rifampicin with other drugs

1980 • 42 citations

Isoniazid with thiacetazone (Thioacetazone) in the treatment of pulmonary tuberculosis in East Africa—third investigation: The effect of an initial streptomycin supplement

1966 • 42 citations

Massive haemolysis caused by rifampicin.

1973 • 41 citations

A controlled trial of daily and intermittent rifampicin plus ethambutol in the retreatment of patients with pulmonary tuberculosis: Results up to 30 months

1975 • 40 citations

Ethambutol-isoniazid versus PAS-isoniazid in original treatment of pulmonary tuberculosis.

1967 • 40 citations

Observations on the reduction of the renal elimination of orate in man caused by the administration of pyrazinamide

1976 • 38 citations

Adverse reactions to short-course regimens containing streptomycin, isoniazid, pyrazinamide and rifampicin in Hong Kong

1976 • 36 citations

Isoniazid with thiacetazone (thioacetazone) in the treatment of pulmonary tuberculosis in East Africa—Fourth investigation: The effect of increasing the dosage of isoniazid†

1966 • 36 citations

Streptomycin : nature and practical applications

1949 • 35 citations

Studies on the use of high dose of isoniazid. I. Toxicity studies.

1954 • 34 citations

Ototoxic Side Effects Following Treatment with Streptomycin, Dihydrostreptomycin, and Kanamycin

1964 • 31 citations

The occurrence of hyperuricemia during pyrazinamide-isoniazid therapy.

1956 • 30 citations

Acute renal failure and rifampicin: danger of unsuspected intermittent dosage.

1974 • 30 citations

A study of acute intolerance to ethionamide, including a comparison with prothionamide, and of the influence of a vitamin B-complex additive in prophylaxis

1969 • 29 citations

Evidence for a Relative Vitamin B6 Deficiency in Pregnancy and Some Disease States

1964 • 29 citations

A controlled comparison of four regimens of streptomycin plus pyrazinamide in the retreatment of pulmonary tuberculosis

1969 • 28 citations

Drug-Induced Deafness

1973 • 27 citations

Toxic and allergic drug reactions during the treatment of tuberculosis

1961 • 26 citations

PERMANENT RENAL DAMAGE WITH RIFAMPICIN

1975 • 25 citations

A second international co-operative investigation into thiacetazone side-effects Rashes on two thiacetazone containing regimens

1971 • 25 citations

Serum enzyme changes in patients receiving antituberculosis therapy with rifampicin or p-aminosalicylic acid, plus isoniazid and streptomycin

1974 • 23 citations

Relationship between rifampicin‐dependent antibody scores, serum rifampicin concentrations and symptoms in patients with adverse reactions to intermittent rifampicin treatment

1973 • 23 citations

THE MECHANISM OF THE GOITROGENIC ACTION OF p-AMINOSALICYLIC ACID

1954 • 23 citations

A concurrent comparison of home and sanatorium treatment of pulmonary tuberculosis in South India.

1959 • 23 citations

Rifampicin and thrombocytopenia.

1971 • 22 citations

Renal failure during intermittent rifampicin therapy

1975 • 22 citations

Ocular toxicity due to rifampicin.

1976 • 22 citations

A controlled comparison of streptomycin plus pyrazinamide and streptomycin plus pas in the retreatment of patients excreting isoniazid-resistant organisms

1964 • 22 citations

Capreomycin-induced serum electrolyte abnormalities

1970 • 21 citations

The delayed appearance of isoniazid antagonism by pyridoxine in vivo.

1957 • 21 citations

Effect of pyridoxine on vitamin B6 concentrations and glutamic-oxaloacetic transaminase activity in whole blood of tuberculous patients receiving high-dosage isoniazid.

1967 • 21 citations

ACUTE RENAL FAILURE AFTER RIFAMPICIN

1972 • 21 citations

Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis. First report.

1978 • 21 citations

THE AUSTRALIAN RIFAMPICIN TRIAL

1972 • 20 citations

Adverse reactions during rifampicin treatment.

1972 • 20 citations

[Jaundice during treatment with rifampicin (12 cases)].

1969 • 20 citations

Toxicity of pyrazinamide, administered once weekly in high dosage, in tuberculous patients.

1968 • 19 citations

CONTROLLED TRIAL OF INTERMITTENT REGIMENS OF RIFAMPICIN PLUS ISONIAZID FOR PULMONARY TUBERCULOSIS IN SINGAPORE

1975 • 19 citations

Controlled trial of intermittent regimens of rifampin plus isoniazid for pulmonary tuberculosis in Singapore. The results up to 30 months.

1977 • 19 citations

Acute gouty arthritis following ethambutol therapy

1980 • 17 citations

A controlled comparison of thiacetazone (thioacetazone) plus isoniazid with pas plus isoniazid in Hong Kong

1968 • 17 citations

Vitamin B6 status of institutionalised and non-institutionalised aged.

1977 • 17 citations

Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration

1979 • 17 citations

Comparative trial of isoniazid in combination with sulphone or PAS in the treatment of acute pulmonary tuberculosis in East Africans

1959 • 16 citations

Side effects of rifampicin. A clinical study.

1973 • 16 citations

A second international cooperative investigation into tioacetazone side effects.

1972 • 15 citations

Treatment with capreomycin, with special reference to toxic effects.

1969 • 14 citations

Hong Kong Treatment Services-Royal Postgraduate Medical School-British Medical Research Council Co-operative study of rifampicin plus ethambutol in daily and intermittent regimens. The detection of rifampicin-dependent antibodies.

1973 • 14 citations

DRUG-INDUCED DEAFNESS

1978 • 14 citations

Complications in the chemotherapy of tuberculosis. A review with analysis of the experience of 3,148 patients.

1961 • 14 citations

Comparative Trial of Isoniazid alone in Low and High Dosage and Isoniazid Plus PAS in the Treatment of Acute Pulmonary Tuberculosis in East Africans. A Co-operative Investigation in East African Hospitals and Laboratories with the collaboration of the British Medical Research Council.

1960 • 14 citations

Acute renal failure after rifampicin therapy.

1973 • 13 citations

Isoniazid plus thioacetazone compared with two regimens of isoniazid plus PAS in the domiciliary treatment of pulmonary tuberculosis in South Indian patients.

1966 • 13 citations

An investigation of the value of ethionamide with pyrazinamide or cycloserine in the treatment of chronic pulmonary tuberculosis

1961 • 13 citations

A Four-Year Clinical Investigation of Ethambutol in Initial and Re-Treatment Cases of Tuberculosis. Efficacy, Toxicity, and Bacterial Resistance.

1966 • 12 citations

The use of pyrazinamide plus isoniazid in the treatment of pulmonary tuberculosis

1959 • 12 citations

A slow-release preparation of isoniazid: therapeutic efficacy and adverse side-effects.

1976 • 11 citations

A second international co-operative investigation into thioacetazone side-effects. 1. The influence of a vitamin and antihistamine supplement.

1970 • 11 citations

Pyrazinamide-isoniazid: comparison with isoniazid-para-aminosalicylic acid in active pulmonary tuberculosis with the choice of regimens determined by chance.

1956 • 11 citations

Antibiotics in Myasthenia Gravis

1964 • 9 citations

Tolerance to ethionamid and PAS in original treatment of tuberculous patients.

1966 • 9 citations

[Comparative study of the treatment of pulmonary tuberculosis by a combination of rifampicin and isoniazid administered daily and twice weekly for a year].

1971 • 9 citations

Clinical results in first treatment and retreatment of advanced pulmonary tuberculosis with rifampicin

1969 • 9 citations

Isoniazid Neuropathies in Malnourished Tuberculous Patients.

1959 • 9 citations

Riboflavin status of institutionalised and non-institutionalised aged.

1977 • 8 citations

A PILOT study of cycloserine toxicity; a United States Public Health Service Cooperative Clinical Investigation.

1956 • 8 citations

Aminoglycoside ototoxicity

1978 • 8 citations

Study of adverse reactions to a once-weekly regimen of streptomycin plus a slow-release preparation of isoniazid in high dosage for six months

1976 • 7 citations

Arthralgia in Pulmonary Tuberculosis during Chemotherapy

1968 • 7 citations

Hämolytische Krise mit akutem Nierenversagen unter Rifampicin-Behandlung

1974 • 7 citations

[Minimum daily efficient dose of ethambutol: general review].

1973 • 6 citations

[Hemolytic crisis due to rifampicin].

1971 • 6 citations

Initial treatment of tuberculosis with streptomycin and isoniazid combined with either aminosalyl or rifampicin.

1973 • 6 citations

[Thrombocytopenia caused by hypersensitivity to rifampicin in intermittent high doses].

1971 • 6 citations

Therapeutic effects and side effects of rifampicin administered daily or twice-weekly.

1973 • 5 citations

[Recurrent hemolytic accidents of immuno-allergic origin during intermittent treatment with rifampicin].

1972 • 5 citations

Streptomycin plus PAS plus pyrazinamide in the retreatment of pulmonary tuberculosis in East Africa: Second report

1973 • 5 citations

Drug-induced skin diseases.

1979 • 4 citations

[Double blind study of the toxicity of different doses of ethambutol given in an intermittent therapeutic regimen with streptomycin, isoniazide and ethambutol].

1973 • 4 citations

Rifampicin-dependent reactions against erythrocytes in the sera of patients receiving rifampicin therapy.

1973 • 4 citations

Isoniazid prophylaxis and deaths in Baltimore, Maryland 1972.

1976 • 4 citations

[Treatment of tuberculosis resistant to 1st line drugs with rifampycin and ethambutol, twice a week, with an initial supplement of kanamycin].

1971 • 4 citations

Singapore Tuberculosis Services/British Medical Research Council study of intermittent rifampicin plus isoniazid for pulmonary tuberculosis: interim results at 12 months

1975 • 3 citations

Streptomycin plus PAS plus pyrazinamide in the retreatment of pulmonary tuberculosis in East Africa. A co-operative controlled study in East African hospitals, clinics and laboratories with the collaboration of the East African and British Medical Research Councils.

1972 • 3 citations

Primary treatment of pulmonary tuberculosis with rifampicin

1971 • 3 citations

The prevention and treatment of isoniazid toxicity in the therapy of pulmonary tuberculosis: 1. An assessment of two vitamin B preparations and glutamic acid.

1963 • 3 citations

An Investigation of the Value of Ethionamide with Pyrazinamide or Cycloserine in the Treatment of Chronic Pulmonary Tuberculosis. A Report from the Research Committee.

1961 • 2 citations

Some observations on the ototoxicity of thiacetazone.

1970 • 2 citations

[Rifampicin; its value and its limitations in tuberculosis, chronic or of severe onset, with or without associated ethambutol].

1969 • 1 citations

Deleted Work

1955 • 0 citations