Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Tumor necrosis factor.

1991 • 568 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Purification and biologic characterization of a specific tumor necrosis factor α inhibitor

1989 • 294 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

1988 • 288 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences

1990 • 267 citations

Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

1987 • 263 citations

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses.

1990 • 215 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Human TNF mutants with selective activity on the p55 receptor

1993 • 182 citations

Down regulation of the receptors for tumor necrosis factor by interleukin 1 and 4 beta-phorbol-12-myristate-13-acetate.

1987 • 181 citations

Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients.

1990 • 154 citations

Tumor necrosis factors — structure, function and mechanism of action

1992 • 143 citations

Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors

1990 • 132 citations

Macrophages rapidly internalize their tumor necrosis factor receptors in response to bacterial lipopolysaccharide

1989 • 131 citations

Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase

1992 • 129 citations

A tumor necrosis factor binding protein is present in human biological fluids

1988 • 122 citations

Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.

1987 • 106 citations

Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.

1993 • 105 citations

Tumor necrosis factor (TNF) up-regulates the expression of p75 but not p55 TNF receptors, and both receptors mediate, independently of each other, up-regulation of transforming growth factor alpha and epidermal growth factor receptor mRNA.

1993 • 102 citations

Evidence for involvement of the growth hormone receptor-associated tyrosine kinase in actions of growth hormone.

1993 • 101 citations

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

1990 • 98 citations

Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells

1989 • 89 citations

Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine

1990 • 86 citations

Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha.

1987 • 84 citations

Tumor necrosis factor increases stability of interleukin-1 mRNA by activating protein kinase C.

1993 • 82 citations

Independent regulation of 55‐kDa and 75‐kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes

1991 • 77 citations

Induction of receptors for tumor necrosis factor-alpha by interferons is not a major mechanism for their synergistic cytotoxic response.

1987 • 76 citations

Antagonistic control of tumor necrosis factor receptors by protein kinases A and C. Enhancement of TNF receptor synthesis by protein kinase A and transmodulation of receptors by protein kinase C.

1989 • 74 citations

Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.

1992 • 67 citations

Characterization and Affinity Cross-linking of Receptors for Human Recombinant Lymphotoxin (Tumor Necrosis Factor-β) on a Human Histiocytic Lymphoma Cell Line, U-937

1989 • 48 citations

Modulation of receptors and cytotoxic response of tumor necrosis factor-alpha by various lectins.

1986 • 47 citations

Staurosporine inhibits neutrophil phagocytosis but not iC3b binding mediated by CR3 (CD11b/CD18).

1991 • 47 citations

Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.

1992 • 44 citations

Inhibition of protein kinase c by the tyrosine kinase inhibitor erbstatin

1990 • 42 citations

Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.

1990 • 39 citations

Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells.

1992 • 36 citations

Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines.

1991 • 36 citations

Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.

1993 • 33 citations

Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.

1993 • 33 citations

Protein kinases negatively affect nuclear factor-kappa B activation by tumor necrosis factor-alpha at two different stages in promyelocytic HL60 cells.

1992 • 31 citations

Effect of genistein, a tyrosine kinase inhibitor, on latent EBV activation induced by cross-linkage of membrane IgG in Akata B cells.

1991 • 26 citations

A protein kinase inhibitor, staurosporine, enhances the expression of phorbol dibutyrate binding sites in human polymorphonuclear leucocytes

1993 • 22 citations

Deleted Work

1955 • 0 citations