Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Localization of cystic fibrosis locus to human chromosome 7cen–q22

1985 • 498 citations

Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker

1985 • 488 citations

A closely linked genetic marker for cystic fibrosis

1985 • 463 citations

Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa.

1984 • 415 citations

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

1987 • 339 citations

A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7

1985 • 332 citations

Caucasian Genes in American Negroes

1969 • 321 citations

Molecular basis and prenatal diagnosis of beta-thalassemia

1988 • 248 citations

Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both.

1984 • 221 citations

Long-range restriction site mapping of mammalian genomic DNA

1986 • 194 citations

Hemophilia A

1985 • 189 citations

Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

1986 • 165 citations

Patterns of polymorphism and linkage disequilibrium for cystic fibrosis

1987 • 156 citations

Evidence for multiple origins of the beta E-globin gene in Southeast Asia.

1982 • 103 citations

Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic flbrosis

1986 • 84 citations

Linkage disequilibrium between cystic fibrosis and linked DNA polymorphisms in Italian families: a collaborative study.

1988 • 73 citations

Cystic Fibrosis in Blacks in Washington, DC

1974 • 69 citations

Cystic fibrosis: population genetics.

1973 • 63 citations

Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

1988 • 59 citations

GENETIC DIFFERENCES BETWEEN CYSTIC FIBROSIS WITH AND WITHOUT MECONIUM ILEUS

1988 • 57 citations

Evidence for Genetic Admixture as a Determinant in the Occurrence of Insulin-dependent Diabetes Mellitus in U.S. Blacks

1982 • 33 citations

Three additional DNA polymorphisms in the met gene and D7S8 locus: Use in prenatal diagnosis of cystic fibrosis

1987 • 31 citations

Genetic analysis of cystic fibrosis using linked DNA markers.

1986 • 29 citations

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data.

1984 • 27 citations

Course of cystic fibrosis in black patients

1976 • 23 citations

Heterozygote advantage.

1977 • 23 citations

IONISED CALCIUM IN NORMAL AND STONE-FORMING URINE

1962 • 17 citations

Linkage of DNA markers to cystic fibrosis in 26 families.

1986 • 15 citations

Mucoviscidosis (cystic fibrosis of the pancreas) in Bantu twin neonates.

1967 • 13 citations

Etiogenesis of the European cystic fibrosis polymorphism: Heterozygote advantage against venereal syphilis?

1982 • 11 citations

Fibrocystic disease of the pancreas in the Bantu.

1959 • 10 citations

The use of association data to identify family members at high risk for marker-linked diseases.

1984 • 8 citations