Antiproliferative and Clinical Antitumor Effects of Interferons

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

The Interferon System

1979 • 1,035 citations

Alpha Interferon for Induction of Remission in Hairy-Cell Leukemia

1984 • 833 citations

Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon Alpha_Ain Chronic Myelogenous Leukemia

1986 • 675 citations

Human leukocyte interferon produced by E. coli is biologically active

1980 • 528 citations

Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma

1980 • 503 citations

Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients

1982 • 381 citations

A Critical Appraisal of the Human Tumor Stem-Cell Assay

1983 • 365 citations

Preliminary Observations on the Effect of Recombinant Leukocyte a Interferon in Homosexual Men with Kaposi's Sarcoma

1983 • 360 citations

Prospective clinical trial of a human tumor cloning system.

1983 • 340 citations

Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia

1983 • 337 citations

Recombinant Alpha-2 Interferon Therapy for Kaposi's Sarcoma Associated with the Acquired Immunodeficiency Syndrome

1984 • 329 citations

The Biology of the Interferon System

1983 • 327 citations

Renal cell carcinoma: antitumor effects of leukocyte interferon.

1983 • 320 citations

The Interferon System

1979 • 306 citations

Treatment of Advanced Non-Hodgkin's Lymphoma with Recombinant Leukocyte a Interferon

1984 • 286 citations

Effects of Leukocyte Interferon on Clinical Symptoms and Hormone Levels in Patients with Mid-Gut Carcinoid Tumors and Carcinoid Syndrome

1983 • 279 citations

Antitumor activity of recombinant-derived interferon alpha in metastatic renal cell carcinoma.

1985 • 278 citations

Recombinant Leukocyte A Interferon: An Active Agent in Advanced Cutaneous T-Cell Lymphomas

1984 • 273 citations

Cloning of Human Tumor Stem Cells

1981 • 269 citations

Preliminary Observations on the Effect of Human Leukocyte Interferon in Non-Hodgkin's Lymphoma

1978 • 267 citations

Synergistic antiviral and antiproliferative activities of Escherichia coli-derived human alpha, beta, and gamma interferons

1984 • 260 citations

The nucleotide sequence of human fibroblast interferon cDNA

1980 • 253 citations

Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment.

1984 • 217 citations

Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon.

1986 • 209 citations

Site-specific mutagenesis of the human fibroblast interferon gene.

1984 • 193 citations

Biology of the interferon system

1983 • 192 citations

Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells.

1982 • 188 citations

Pharmacokinetics, single-dose tolerance, and biological activity of recombinant gamma-interferon in cancer patients.

1985 • 185 citations

Intraperitoneal recombinant alpha-interferon for "salvage" immunotherapy in stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study.

1985 • 181 citations

The Treatment of Renal Cell Carcinoma with Human Leukocyte Alpha-Interferon

1983 • 178 citations

Interferon: Immunobiology and Clinical Significance

1982 • 177 citations

Immunotherapy of Human Cancer

1983 • 174 citations

Comparison of Intramuscular and Intravenous Recombinant Alpha-2 Interferon in Melanoma and Other Cancers

1985 • 173 citations

Treatment of hairy cell leukemia with recombinant alpha 2 interferon

1985 • 157 citations

Potentiation of interferon activity by mixed preparations of fibroblast and immune interferon

1979 • 156 citations

ALLELIC RESTRICTION

1976 • 149 citations

Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay

1983 • 147 citations

Recombinant leukocyte A interferon therapy for advanced hairy cell leukemia. Therapeutic and immunologic results

1986 • 141 citations

Phase II study of recombinant leukocyte a interferon (rIFN-αA) in disseminated malignant melanoma

1984 • 140 citations

A randomized study of low and high doses of leukocyte alpha-interferon in metastatic renal cell carcinoma: the American Cancer Society collaborative trial.

1985 • 139 citations

Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system.

1984 • 136 citations

Treatment of hairy cell leukemia with recombinant alpha 2 interferon

1985 • 134 citations

Leukocyte-Derived Interferon (Alpha) in Human Breast Carcinoma

1982 • 131 citations

Treatment of multiple myeloma with recombinant alpha-interferon

1986 • 129 citations

Effects of cloned human leukocyte interferons in the human tumor stem cell assay.

1983 • 127 citations

Follow-up observations on the effect of human leukocyte interferon in non-Hodgkin's lymphoma

1981 • 120 citations

Cloning of human tumor stem cells

1980 • 119 citations

Phase II trial of recombinant leukocyte A interferon in patients with advanced chronic lymphocytic leukemia

1985 • 112 citations

Human lymphoblastoid interferon treatment of Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical response and prognostic parameters

1985 • 111 citations

Immunotherapy of Human Cancer

1982 • 110 citations

Phase II study of recombinant alpha-2 interferon in resistant multiple myeloma.

1985 • 108 citations

Oyster and Virus

1964 • 108 citations

Phase II study of interferon alpha in metastatic renal-cell carcinoma: a progress report.

1985 • 106 citations

Recombinant alpha-2-interferon for hairy cell leukemia

1985 • 104 citations

Collaborative phase I-II study of recombinant DNA-produced leukocyte interferon (clone A) in metastatic breast cancer, malignant lymphoma, and multiple myeloma

1984 • 102 citations

Treatment of acquired immunodeficiency syndrome--related Kaposi's sarcoma with lymphoblastoid interferon.

1985 • 101 citations

Human interferon alpha in malignant lymphoma and Hodgkin's disease. Results of the american cancer society trial

1985 • 101 citations

Human leukocyte interferon preparation blocks granulopoietic differentiation

1979 • 98 citations

Inhibitory Effects of Human Leukocyte and Fibroblast Interferons on Normal and Chronic Myelogenous Leukemic Granulocytic Progenitor Cells

1981 • 93 citations

Human interferon inhibits the growth of established human breast tumours in the nude mouse

1982 • 93 citations

Phase II study of low-dose recombinant leukocyte A interferon in disseminated malignant melanoma.

1984 • 93 citations

Human Leukocyte Interferon to Control Thrombocytosis in Chronic Myelogenous Leukemia

1983 • 91 citations

Potentiation of antitumor effect of virus-induced interferon by mouse immune interferon preparations.

1980 • 83 citations

Interferon-alpha therapy of renal cancer.

1984 • 83 citations

Immunobiology of primary intracranial tumors

1985 • 83 citations

Interferon potentiates cytotoxic effects of 5-fluorouracil on cell proliferation of established human cell lines originating from neoplastic tissues

1983 • 73 citations

Synergistic antiproliferative effects of human recombinant alpha 54- or beta ser-interferon with gamma-interferon on human cell lines of various histogenesis.

1986 • 68 citations

Evaluation of human lymphoblastoid interferon in advanced malignant melanoma

1983 • 63 citations

Interferon and natural killer activity in multiple myeloma. Lack of correlation between interferon‐induced enhancement of natural killer activity and clinical response to human interferon‐α

1982 • 63 citations

Treatment of hepatocellular carcinoma with recombinant leucocyte interferon: A pilot study

1985 • 61 citations

Effect of human leukocyte interferon on malignant brain tumors

1983 • 61 citations

Phase I evaluation of a synthetic mutant of beta-interferon.

1985 • 60 citations

Effect of fibroblast, lymphoid, and myeloid interferons on human tumor colony formation in vitro.

1981 • 59 citations

Phase II study of recombinant leukocyte A interferon (IFN-rA) plus cimetidine in disseminated malignant melanoma.

1985 • 58 citations

Interferon Treatment For Multiple Myeloma

1982 • 53 citations

Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drug-metabolizing enzymes.

1984 • 53 citations

Recombinant Leukocyte A Interferon in Advanced Breast Cancer

1983 • 52 citations

The effect of systemic human interferon-alpha administration to patients with glioblastoma multiforme

1983 • 51 citations

Treatment of multiple myeloma with recombinant interferon alfa-2a

1986 • 51 citations

Inhibition of growth of B16 murine malignant melanoma by exogenous interferon.

1980 • 49 citations

Human Brain Tumor—Derived Cell Lines: Growth Rate Reduced by Human Fibroblast Interferon

1983 • 49 citations

Human lymphoblastoid interferon can inhibit the growth of human breast cancer xenografts in athymic (nude) mice

1980 • 48 citations

Synergistic activities of type I (α, β) and type II (γ) murine interferons

1982 • 46 citations

Enhanced Expression of Melanoma-Associated Antigens and β<sub>2</sub>-Microglobulin on Cultured Human Melanoma Cells by Interferon<xref ref-type="fn" rid="FN2">2</xref>

1982 • 45 citations

APPLICATION OF HUMAN LEUCOCYTE INTERFERON IN PATIENTS WITH CARCINOMA OF THE UTERINE CERVIX

1981 • 45 citations

Antiproliferative Effects of Interferons on Human Melanoma Cells in the Human Tumor Colony-Forming Assay

1986 • 44 citations

Phase I study of pharmacological and immunological effects of human lymphoblastoid interferon given to patients with cancer.

1983 • 42 citations

Comparative in vivo and in vitro activation of human natural killer cells by two recombinant alpha-interferons differing in antiviral activity.

1984 • 40 citations

Systemic IFN-Alpha Treatment of Multiple Bladder Papilloma Grade I or II Patients: Pilot Study

1982 • 39 citations

Recombinant interferon in advanced breast cancer

1984 • 39 citations

Treatment of nasopharyngeal carcinoma with human leukocyte interferon.

1985 • 37 citations

Augmented antiproliferative effects of interferons at elevated temperatures against human bladder carcinoma cell lines.

1984 • 36 citations

Interferon-gamma: success, structure and speculation

1982 • 34 citations

A phase II study of recombinant alpha interferon in patients with recurrent or metastatic breast cancer.

1984 • 34 citations

Interferon therapy in disseminated renal cell carcinoma

1985 • 31 citations

Differential modulation by recombinant immune interferon of the expression and shedding of HLA antigens and melanoma associated antigens by a melanoma cell line resistant to the antiproliferative activity of immune interferon.

1985 • 30 citations

Clinical, serologic, and immunologic effects of human leukocyte interferon in HBsAg-positive primary hepatocellular carcinoma

1985 • 27 citations

Activity of human leukocyte interferon in a human tumor cloning system

1982 • 26 citations

Recombinant DNA human interferon alpha 2 in advanced breast cancer: A phase 2 trial

1985 • 24 citations

Human tumor stem cell assay: A prospective clinical trial

1984 • 24 citations

Effects of human lymphoblastoid interferon on cultured breast cancer cells

1981 • 22 citations

Antiproliferative Activity of Human Interferons Against Ovarian Cancer Cells Grown in Human Tumor Stem Cell Assay

1984 • 21 citations

Experience with human lymphoblastoid interferon in acute myelogenous leukaemia (AML)

1983 • 21 citations

In Vitro Cloning and Chemosensitivity of Human Myeloma Stem Cells

1982 • 20 citations

Direct action of interferon and inducers of interferon on tumor cells in athymic nude mice.

1983 • 19 citations

Treatment of non-hodgkin's lymphoma of low-grade malignancy with human fibroblast interferon.

1982 • 18 citations

An Animal Model System for Investigating the AntiTumor Effects of Human Interferon

1983 • 15 citations

Treatment of lymphoid neoplasias with interferon. II. Human leucocyte alpha-interferon in chronic lymphatic leukemia (CLL). PHase I-II trial.

1982 • 11 citations