Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Faster sequential genetic linkage computations.

1993 • 1,378 citations

The Handbook of proteolytic enzymes

1998 • 1,123 citations

Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis

1998 • 686 citations

[2] Families of serine peptidases

1994 • 621 citations

Two Distinct Cytokines Released from a Human Aminoacyl-tRNA Synthetase

1999 • 493 citations

Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

1989 • 388 citations

PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

1994 • 315 citations

Cyclical Neutropenia and Other Periodic Hematological Disorders: A Review of Mechanisms and Mathematical Models

1998 • 238 citations

Cyclic neutropenia: A clinical review

1988 • 234 citations

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

1989 • 231 citations

Primary structure of human neutrophil elastase.

1987 • 227 citations

Identification of a serpin-enzyme complex receptor on human hepatoma cells and human monocytes.

1990 • 190 citations

Structure of the human neutrophil elastase gene.

1988 • 142 citations

Myelomonocytic cell lineage expression of the neutrophil elastase gene.

1988 • 119 citations

Genetics, phenotype, and natural history of autosomal dominant cyclic hematopoiesis

1996 • 96 citations

Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.

1996 • 86 citations

Congenital End-Plate Acetylcholinesterase Deficiency Caused by a Nonsense Mutation and an A→G Splice-Donor–Site Mutation at Position +3 of the Collagenlike-Tail–Subunit Gene (COLQ): How Does G at Position +3 Result in Aberrant Splicing?

1999 • 80 citations

Characterization of the P₂‘ and P₃‘ Specificities of Thrombin Using Fluorescence-Quenched Substrates and Mapping of the Subsites by Mutagenesis^,

1996 • 78 citations

Inhibition of Human Neutrophil Elastase. 4. Design, Synthesis, X-ray Crystallographic Analysis, and Structure−Activity Relationships for a Series of P₂-Modified, Orally Active Peptidyl Pentafluoroethyl Ketones

1998 • 58 citations

The GDBTM Human Genome Database Anno 1997

1997 • 44 citations

Converting trypsin to elastase: substitution of the S1 site and adjacent loops reconstitutes esterase specificity but not amidase activity

1998 • 35 citations

Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase

1996 • 30 citations