Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

The structure of protein-protein recognition sites.

1990 • 825 citations

Human α1-proteinase inhibitor

1984 • 773 citations

Structural basis of the activation and action of trypsin

1978 • 669 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors

1983 • 580 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

What do dysfunctional serpins tell us about molecular mobility and disease?

1995 • 420 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

Molecular recognition

1991 • 362 citations

Biological implications of a 3 å structure of dimeric antithrombin

1994 • 360 citations

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

1994 • 279 citations

A Buried Polar Interaction Imparts Structural Uniqueness in a Designed Heterodimeric Coiled Coil

1998 • 250 citations

Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

1995 • 240 citations

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

1989 • 231 citations

Structural transition of α₁‐antitrypsin by a peptide sequentially similar to β‐strand s4A

1990 • 197 citations

Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 Å resolution

1982 • 186 citations

Effects of mutations in the hinge region of serpins

1993 • 183 citations

The Inhibition Mechanism of Serpins

1995 • 176 citations

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1994 • 175 citations

Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins

1991 • 166 citations

Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin

1990 • 164 citations

Structural basis for serpin inhibitor activity

1995 • 157 citations

Serpin tertiary structure transformation

1991 • 155 citations

Substrate properties of C1 inhibitor Ma (alanine 434—-glutamic acid). Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status

1991 • 147 citations

Crystal Structure of Cleaved Bovine Antithrombin III at 3·2 Å Resolution

1993 • 111 citations

A hinge region mutation in C1-inhibitor (Ala436–>Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.

1993 • 111 citations

COOH-terminal Substitutions in the Serpin C1 Inhibitor That Cause Loop Overinsertion and Subsequent Multimerization

1995 • 105 citations

.alpha.1-Proteinase Inhibitor Variant T345R. Influence of P14 Residue on Substrate and Inhibitory Pathways

1994 • 99 citations

Antithrombin-III-Hamilton: a gene with a point mutation (guanine to adenine) in codon 382 causing impaired serine protease reactivity

1988 • 88 citations

Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A

1992 • 77 citations

Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1·95Å resolution

1992 • 68 citations

Trypsin complexed with α₁‐proteinase inhibitor has an increased structural flexibility

1995 • 65 citations

C1 inhibitor hinge region mutations produce dysfunction by different mechanisms

1992 • 64 citations

Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A .beta.-sheet of the inhibitor during trapping of target proteinases

1993 • 62 citations

Antithrombin Cambridge, 384 Ala to Pro: A new variant identified using the polymerase chain reaction

1989 • 60 citations

The Contribution of the Conserved Hinge Region Residues of .alpha.1-Antitrypsin to Its Reaction with Elastase

1995 • 56 citations

Effect of heparin on the glia-derived-nexin-thrombin interaction

1989 • 53 citations

Antithrombin Cambridge II, 384 Ala to Ser Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins

1991 • 49 citations

Antithrombin III Budapest: a single amino acid substitution (429Pro to Leu) in a region highly conserved in the serpin family

1992 • 46 citations

Regulation of Thrombin by Antithrombin and Heparin Cofactor II

1992 • 41 citations

Kinetic Studies on the Interaction of α₁-Proteinase Inhibitor (Pittsburgh) with Trypsin-Like Serine Proteinases

1986 • 39 citations

Sequence alignment approach to pick up conformationally similar protein fragments

1992 • 26 citations

Conformational Change in Antithrombin Induced by Heparin, Probed with a Monoclonal Antibody against the 1C/4B Region

1994 • 19 citations

Modeling the uncleaved serpin antichymotrypsin and its chymotrypsin complex

1993 • 15 citations

Macromolecular marionettes

1977 • 14 citations