Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects.

Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity

1978 • 1,651 citations

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

1973 • 1,363 citations

Ion effects on ligand-nucleic acid interactions

1976 • 1,016 citations

Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

1983 • 651 citations

Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The Escherichia coli lac repressor-operator interaction: kinetic measurements and conclusions

1981 • 579 citations

Heparin : chemical and biological properties, clinical applications

1989 • 497 citations

Mechanism of the anticoagulant action of heparin

1982 • 486 citations

Further characterization of the antithrombin-binding sequence in heparin

1982 • 450 citations

Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4

1984 • 344 citations

The kinetics of hemostatic enzyme-antithrombin interactions in the presence of low molecular weight heparin.

1980 • 342 citations

Extension and structural variability of the antithrombin-binding sequence in heparin.

1984 • 340 citations

Studies on the Active Center of Trypsin

1965 • 330 citations

Thrombosis and haemostasis

1988 • 327 citations

Regression analysis of nonlinear Arrhenius plots: An empirical model and a computer program

1984 • 313 citations

The molecular-weight-dependence of the anti-coagulant activity of heparin

1978 • 273 citations

Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa.

1986 • 254 citations

Quantitative characterization of the thrombin-heparin interaction. Discrimination between specific and nonspecific binding models.

1991 • 230 citations

Binding of high affinity heparin to antithrombin III. Stopped flow kinetic studies of the binding interaction.

1981 • 222 citations

Fractionation of low molecular weight heparin species and their interaction with antithrombin.

1979 • 208 citations

Pentalysine-deoxyribonucleic acid interactions: a model for the general effects of ion concentrations on the interactions of proteins with nucleic acids

1980 • 200 citations

Multiple functional domains of the heparin molecule.

1981 • 191 citations

Demonstration of a two-step reaction mechanism for inhibition of alpha-thrombin by antithrombin III and identification of the step affected by heparin.

1982 • 180 citations

Kinetics of the heparin-enhanced antithrombin III/thrombin reaction. Evidence for a template model for the mechanism of action of heparin.

1982 • 172 citations

The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen.

1990 • 146 citations

Binding of high affinity heparin to antithrombin III. Characterization of the protein fluorescence enhancement.

1981 • 144 citations

A simple rate law that describes the kinetics of the heparin-catalyzed reaction between antithrombin III and thrombin.

1983 • 130 citations

A catalytic role for heparin

1978 • 128 citations

Purine nucleoside phosphorylase cleaves the C–O bond of ribose 1-phosphate. Evidence from the 18O shift in 31P NMR

1979 • 118 citations

Involvement of heparin chain length in the heparin-catalyzed inhibition of thrombin by antithrombin III.

1984 • 117 citations

p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.

1982 • 107 citations

Transient Kinetics of Heparin-catalyzed Protease Inactivation by Antithrombin III

1989 • 100 citations

Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. Linkage of protease-inhibitor-heparin interactions in the reaction with thrombin.

1988 • 92 citations

Circular dichroism spectroscopy of heparin-antithrombin interactions

1982 • 71 citations

Influence of ionic strength and pH on the interaction between high-affinity heparin and antithrombin

1981 • 58 citations

Transient kinetics of heparin-catalyzed protease inactivation by antithrombin III. The reaction step limiting heparin turnover in thrombin neutralization.

1986 • 55 citations

Antithrombin conformation and the catalytic role of heparin. II. Is the heparin-induced conformational change in antithrombin required for rapid inactivation of thrombin?

1987 • 38 citations

Decreased Heparin Sensitivity of Cyclohexanedione-Modified Thrombin

1978 • 31 citations

Antithrombin III

1990 • 29 citations

Reaction of thrombins with human antithrombin III I. Enzyme activity losses unrelated to the inhibitory reaction and their prevention

1986 • 27 citations

Examination, by 1H-n.m.r. spectroscopy, of the binding of a synthetic, high-affinity heparin pentasaccharide to human antithrombin III

1989 • 18 citations

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