A spontaneous point mutation in the single 23S rRNA gene of the thermophilic arachaeon Sulfolobus acidocaldarius confers multiple drug resistance

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

Sulfolobus: A new genus of sulfur-oxidizing bacteria living at low pH and high temperature

1972 • 1,227 citations

Thermus aquaticus gen. n. and sp. n., a Nonsporulating Extreme Thermophile

1969 • 675 citations

Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA

1987 • 337 citations

Substrate‐and Antibiotic‐Binding Sites at the Peptidyl‐Transferase Centre of Escherichia coli Ribosomes

1971 • 148 citations

Studies on Transfer Ribonucleic Acid-Ribosome Complexes

1972 • 128 citations

Mitochondrial DNA of chloramphenicol-resistant mouse cells contains a single nucleotide change in the region encoding the 3' end of the large ribosomal RNA.

1981 • 106 citations

An intron in the 23S ribosomal RNA gene of the archaebacterium Desulfurococcus mobilis

1985 • 89 citations

Insensitivity of archaebacterial ribosomes to protein synthesis inhibitors. Evolutionary implications.

1985 • 85 citations

A site-specific endonuclease encoded by a typical archaeal intron.

1993 • 80 citations

Interaction of the antibiotics clindamycin and lincomycin withEscherichia coli23S ribosomal RNA

1992 • 78 citations

Chloramphenicol resistance mutations in the single 23S rRNA gene of the archaeon Halobacterium halobium

1991 • 72 citations

Archaeal rRNA operons

1991 • 71 citations

23S Ribosomal RNA mutations in halobacteria conferring resistance to the anti-80S ribosome targeted antibiotic anisomycin

1987 • 63 citations

A conserved secondary structural motif in 23S rRNA defines the site of interaction of amicetin, a universal inhibitor of peptide bond formation.

1994 • 47 citations

Thiostrepton resistance mutations in the gene for 23S ribosomal RNA of Halobacteria

1987 • 44 citations

Sequence analysis of mitochondrial DNA in a mouse cell line resistant to chloramphenicol and oligomycin.

1983 • 44 citations

Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs

1991 • 37 citations

Introducing mutations into the single-copy chromosomal 23S rRNA gene of the archaeon Halobacterium halobium by using an rRNA operon-based transformation system.

1992 • 37 citations

Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism

1990 • 34 citations

Structure-activity relationships of sparsomycin and its analogs. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth

1987 • 33 citations

High Efficiency of Plating of the Thermophilic Sulfur-Dependent Archaebacterium Sulfolobus acidocaldarius

1989 • 28 citations

A mutation in the large subunit ribosomal RNA gene of Tetrahymena confers anisomycin resistance and cold sensitivity.

1991 • 23 citations

Sequence Analysis of Mitochondrial DNA in a Mouse Cell Line Resistant to Chloramphenicol and Oligomycin

1983 • 17 citations