S-Nitrosothiols and the Bioregulatory Actions of Nitrogen Oxides Through Reactions with Thiol Groups

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

1994 • 1,704 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

The biology of nitrogen oxides in the airways.

1994 • 928 citations

Management of patients with intramural hematoma of the thoracic aorta.

1993 • 896 citations

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

1993 • 865 citations

Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.

1986 • 826 citations

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

1992 • 737 citations

Biochemistry of the SH group

1972 • 714 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators

1991 • 478 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Nitric oxide-induced blockade of NMDA receptors

1992 • 455 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

S‐nitroso‐glutathione inhibits platelet activation in vitro and in vivo

1992 • 330 citations

Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary.

1994 • 316 citations

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

1980 • 313 citations

Reversible Binding of Nitric Oxide by a Salivary Heme Protein from a Bloodsucking Insect

1993 • 312 citations

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

1991 • 311 citations

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

1993 • 294 citations

Oxidation of thiols by nitric oxide and nitrogen dioxide: synthetic utility and toxicological implications

1982 • 288 citations

An unusually stable thionitrite from N-acetyl-D,L-penicillamine; X-ray crystal and molecular structure of 2-(acetylamino)-2-carboxy-1,1-dimethylethyl thionitrite

1978 • 281 citations

N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.

1989 • 245 citations

Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.

1990 • 237 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.

1985 • 188 citations

Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron

1987 • 183 citations

S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

1992 • 182 citations

Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite

1994 • 180 citations

Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds

1980 • 173 citations

Identification and characterization of some bacterial membrane sulfhydryl groups which are targets of bacteriostatic and antibiotic action.

1984 • 154 citations

Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor.

1993 • 153 citations

Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro.

1994 • 151 citations

Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives

1992 • 151 citations

Factors Affecting the Bacteriostatic Action of Sodium Nitrite

1955 • 138 citations

Reaction of S-nitrosoglutathione with sulfhydryl groups in protein

1988 • 110 citations

Mechanisms for the pharmacologic interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine.

1988 • 108 citations

The relaxant properties in guinea pig airways of S-nitrosothiols.

1992 • 101 citations

ORGANIC THIONITRITES AND RELATED SUBSTANCES. A REVIEW

1983 • 96 citations

Diffusion Control and Pre-association in Nitrosation, Nitration and Halogenation

1978 • 91 citations

New syntheses of thionitrites and their chemical reactivites

1978 • 85 citations

Biochemical and pharmacological interactions between nitroglycerin and thiols

1991 • 79 citations

Effect of sodium nitrite inhibition on intracellular thiol groups and on the activity of certain glycolytic enzymes in Clostridium perfringens

1976 • 79 citations

Factors Affecting the Bacteriostatic Action of Sodium Nitrite1

1955 • 72 citations

Electron spin resonance spin trapping of thiyl, radicals from the decomposition of thionitrites

1984 • 71 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

Inhibition of Bacillus cereus spore outgrowth by covalent modification of a sulfhydryl group by nitrosothiol and iodoacetate

1981 • 63 citations

Novel method of activating thiols by their conversion into thionitrites with dinitrogen tetroxide

1977 • 60 citations

Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase

1992 • 58 citations

CCXII.—The action of mercaptans on acid chlorides. Part II. The acid chlorides of phosphorus, sulphur, and nitrogen

1909 • 56 citations

Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation

1988 • 54 citations

Antibacterial Effect of Cysteine-Nitrosothiol and Possible Percursors Thereof

1974 • 52 citations

The reaction between organic nitrates and sulfhydryl compounds. A possible model system for the activation of organic nitrates.

1985 • 50 citations

Reaction of acidified nitrite solutions with peptide derivatives: evidence for nitrosamine and thionitrite formation from 15N N.m.r. Studies

1975 • 42 citations

ChemInform Abstract: ORGANIC THIONITRITES AND RELATED SUBSTANCES. A REVIEW

1984 • 42 citations

The involvement of catalytic site thiol groups in the activation of soluble guanylate cyclase by sodium nitroprusside

1986 • 40 citations

Oxidation of dithiothreitol during turnover of nitric oxide reductase: evidence for generation of nitroxyl with the enzyme from Paracoccus denitrificans

1992 • 38 citations

Gas-phase ion-molecule reactions of the nitric oxide anion

1989 • 34 citations

Reactions of thiyl radicals. II. The photolysis of methyl disulfide vapor

1967 • 34 citations

Evidence that S-nitrosothiols are responsible for the smooth muscle relaxing activity of the bovine retractor penis inhibitory factor.

1992 • 33 citations

The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs.

1991 • 32 citations

S‐nitrosocysteine (RSNO), an effective antioxidant in cured meat

1979 • 32 citations

Under anaerobic conditions, soluble guanylate cyclase is specifically stimulated by glutathione

1989 • 28 citations

Spectroscopic estimation of the extent of S-nitrosothiol formation by nitrite action on sulfhydryl groups

1983 • 27 citations

Inhibition of Clostridium Botulinum by Sodium Nitrite as Affected by Bacteriological Media and Meat Suspensions

1971 • 25 citations

Nitrosyl‐Derivate des zweiwertigen Schwefels, I.: Das Nitrosyl‐äthylmercaptid

1926 • 25 citations

A study of the competitive nitrosations of pyrrolidine, ascorbic acid, cysteine and p‐cresol in a protein‐based model system

1978 • 24 citations

A kinetic investigation of the thionitrite from (±)-2-acetylamino2-carboxy-1,1-dimethylethanethiol as a possible nitrosating agent

1982 • 23 citations

Kinetics and mechanism of the nitrosation of alcohols, carbohydrates, and a thiol

1982 • 22 citations

Antibacterial Effect of Cysteine-Nitrosothiol and Possible Percursors Thereof

1974 • 20 citations

The antithrombotic effects of organic nitrates

1991 • 18 citations

Environmental health criteria 4: Oxides of nitrogen

1979 • 17 citations

Environmental Health Criteria. 4. Oxides of Nitrogen

1979 • 16 citations

Thiol-mediated catalysis of nitroglycerin degradation by serum proteins. Increase in metabolism was not accompanied by S-nitrosothiol production.

1990 • 16 citations