Depletion of CCR5-Expressing Cells with Bispecific Antibodies and Chemokine Toxins: A New Strategy in the Treatment of Chronic Inflammatory Diseases and HIV

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

Human Chemokines: An Update

1997 • 2,235 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

1998 • 1,382 citations

Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

1997 • 1,373 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

"Diabodies": small bivalent and bispecific antibody fragments.

1993 • 861 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.

1989 • 712 citations

Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene

1996 • 701 citations

Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: A mechanism for cellular human immunodeficiency virus 1 infection

2000 • 587 citations

Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages

1999 • 577 citations

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

1997 • 489 citations

Hybrid antibodies can target sites for attack by T cells

1985 • 479 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity

1998 • 409 citations

The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells.

1998 • 409 citations

Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells

1998 • 341 citations

Latent reservoirs of HIV: Obstacles to the eradication of virus

1999 • 337 citations

A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity.

1995 • 337 citations

Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes

1998 • 238 citations

Immunotoxins in cancer therapy

1999 • 214 citations

Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells.

1994 • 209 citations

Hybrid hybridoma producing a bispecific monoclonal antibody that can focus effector T-cell activity.

1986 • 206 citations

Expression of the C-C chemokine receptor 5 in human kidney diseases

1999 • 173 citations

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

2000 • 155 citations

Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritis

1999 • 142 citations

Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication

1998 • 137 citations

Association of rheumatoid arthritis with a functional chemokine receptor, CCR5

1999 • 136 citations

Construction, expression, and activity of a bivalent bispecific single-chain antibody.

1994 • 120 citations

Efficient tumor cell lysis mediated by a bispecific single chain antibody expressed in Escherichia coli.

1994 • 101 citations

Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity.

1997 • 86 citations

Chemokine receptor (CCR5) expression in human kidneys and in the HIV infected macaque

1998 • 56 citations

Immunotoxins made with a recombinant form of Pseudomonas exotoxin A that do not require proteolysis for activity.

1993 • 51 citations

Retargeting of CTL by an efficiently refolded bispecific single-chain Fv dimer produced in bacteria.

1995 • 48 citations

Specific Killing of HIV-infected Lymphocytes by a Recombinant Immunotoxin Directed against the HIV-1 Envelope Glycoprotein

1998 • 38 citations

Downmodulation and Recycling of Chemokine Receptors

2003 • 8 citations