Guanine nucleotide-binding proteins in the intestinal parasite Giardia lamblia. Isolation of a gene encoding an approximately 20-kDa ADP-ribosylation factor.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

ras GENES

1987 • 3,818 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Evolution of the cytochromeb gene of mammals

1991 • 2,289 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes.

1989 • 1,295 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Phylogenetic Meaning of the Kingdom Concept: an Unusual Ribosomal RNA from Giardia lamblia

1989 • 715 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

G protein involvement in receptor-effector coupling.

1988 • 618 citations

The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.

1986 • 533 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

ADP-ribosylation factor is functionally and physically associated with the Golgi complex.

1990 • 372 citations

Fundamentals of molecular evolution

1991 • 353 citations

Molecular cloning and characterization of GPA1, a G protein alpha subunit gene from Arabidopsis thaliana.

1990 • 341 citations

Adp-Ribosylating Toxins and G Proteins: Insights into Signal Transduction

1990 • 285 citations

Bidirectional solid-phase sequencing of in vitro-amplified plasmid DNA.

1991 • 264 citations

ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes.

1990 • 257 citations

Restriction-Endonuclease Analysis of DNA from 15 Giardia Isolates Obtained from Humans and Animals

1985 • 231 citations

Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA sequence analysis: Kbm9 and Kbm6.

1986 • 222 citations

Magnetic separation of DNA

1989 • 214 citations

Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.

1991 • 207 citations

Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.

1988 • 204 citations

The neutral theory of molecular evolution and the world view of the neutralists

1989 • 199 citations

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

1989 • 175 citations

Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.

1988 • 175 citations

Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.

1987 • 170 citations

Improved hybridization assays employing tailed oligonucleotide probes: A direct comparison with 5′-end-labeled oligonucleotide probes and nick-translated plasmid probes

1985 • 161 citations

Highly conserved sequencim in the 3′ untranslated region of mRNAs coding for homologous proteins in distantly related species

1985 • 155 citations

Sorting of cyst wall proteins to a regulated secretory pathway during differentiation of the primitive eukaryote, Giardia lamblia.

1990 • 150 citations

Antigenic variation in Giardia lamblia.

1988 • 147 citations

Isolation and expression of the gene for a major surface protein of Giardia lamblia.

1990 • 144 citations

Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain.

1988 • 141 citations

Transduction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so …

1990 • 116 citations

Affinity generation of single-stranded DNA for dideoxy sequencing following the polymerase chain reaction

1989 • 113 citations

Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.

1989 • 109 citations

Highly degenerate, inosine-containing primers specifically amplify rare cDNA using the polymerase chain reaction

1988 • 108 citations

Enhancement of choleragen ADP-ribosyltransferase activities by guanyl nucleotides and a 19-kDa membrane protein.

1987 • 107 citations

Guanine nucleotide-binding proteins that enhance choleragen ADP-ribosyltransferase activity: nucleotide and deduced amino acid sequence of an ADP-ribosylation factor cDNA.

1988 • 99 citations

Cysteine-rich variant surface proteins of Giardia lamblia

1989 • 96 citations

Carboxy-terminal sequence conservation among variant-specific surface proteins of Giardia lamblia

1991 • 94 citations

Cytotoxicity of monoclonal antibodies to a subset of Giardia isolates.

1986 • 88 citations

Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.

1991 • 77 citations

The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system.

1989 • 65 citations

Characterization of a G-protein β-subunit gene from the nematode Caenorhabditis elegans

1990 • 64 citations

Selective amplification of an mRNA and related pseudogene for a human ADP-ribosylation factor, a guanine nucleotide-dependent protein activator of cholera toxin.

1990 • 63 citations

Evidence for unusually short tubulin mRNA leaders and characterization of tubulin genes in Giardia lamblia

1989 • 47 citations

[37] Hornopolymeric tailing

1987 • 45 citations

Tissue and species distribution of mRNA encoding two ADP-ribosylation factors, 20-kDa guanine nucleotide binding proteins

1989 • 32 citations

Diverse Biological Functions of Small GTP-binding Proteins in Yeast

1988 • 30 citations

Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16.

1991 • 23 citations

A heat shock protein gene inGiardia lambliaunrelated to HSP70

1990 • 13 citations

DNA Fingerprinting of the Human Intestinal Parasite Giardia intestinalis with Hypervariable Minisatellite Sequences

1991 • 11 citations