Gene Therapy for Cardiovascular Disorders

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

Gene therapy - promises, problems and prospects

1997 • 1,692 citations

Angiogenesis Gene Therapy

1999 • 673 citations

Nonviral Vectors in the New Millennium: Delivery Barriers in Gene Transfer

2001 • 576 citations

Cytostatic Gene Therapy for Vascular Proliferative Disorders with a Constitutively Active form of the Retinoblastoma Gene Product

1995 • 455 citations

[40] Use of retroviral vectors for gene transfer and expression

1993 • 412 citations

Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca ²⁺ -ATPase in a Rat Model of Heart Failure

2001 • 374 citations

Development of lentiviral vectors for gene therapy for human diseases

2000 • 241 citations

Adeno-associated virus vectors for gene therapy: more pros than cons?

2000 • 229 citations

Production of first generation adenovirus vectors: a review

2000 • 219 citations

In vivo suppression of injury-induced vascular smooth muscle cell accumulation using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene.

1994 • 184 citations

The HIV Tat protein transduction domain improves the biodistribution of β-glucuronidase expressed from recombinant viral vectors

2001 • 159 citations

Prospects for Gene Therapy for Heart Failure

2000 • 155 citations

Pharmacokinetics of antisense oligodeoxyribonucleotides (cyclin B1 and CDC 2 kinase) in the vessel wall in vivo: enhanced therapeutic utility for restenosis by HVJ-liposome delivery

1994 • 153 citations

Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury

2001 • 146 citations

Adrenomedullin Gene Delivery Attenuates Hypertension, Cardiac Remodeling, and Renal Injury in Deoxycorticosterone Acetate-Salt Hypertensive Rats

2000 • 122 citations

Gene therapy using HVJ-liposomes: the best of both worlds?

1999 • 106 citations

Chronic control of high blood pressure in the spontaneously hypertensive rat by delivery of angiotensin type 1 receptor antisense.

1996 • 105 citations

Thromboresistance of Balloon-Injured Porcine Carotid Arteries After Local Gene Transfer of Human Tissue Factor Pathway Inhibitor

2000 • 95 citations

Local Overexpression of Thrombomodulin for In Vivo Prevention of Arterial Thrombosis in a Rabbit Model

1999 • 92 citations

Gene Correction of the Apolipoprotein (Apo) E2 Phenotype to Wild-type ApoE3 by in Situ Chimeraplasty

2001 • 86 citations

Expression and Function of Recombinant Endothelial Nitric Oxide Synthase Gene in Canine Basilar Artery After Experimental Subarachnoid Hemorrhage

1998 • 81 citations

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure

2000 • 78 citations

Development of lentiviral vectors for gene therapy for human diseases

2000 • 77 citations

Decoy Administration of NF-κB into the Subarachnoid Space for Cerebral Angiopathy

1998 • 73 citations

Gene therapy to promote thromboresistance: Local overexpression of tissue plasminogen activator to prevent arterial thrombosis in an in vivo rabbit model

1999 • 71 citations

Human Adrenomedullin Gene Delivery Protects against Cardiac Hypertrophy, Fibrosis, and Renal Damage in Hypertensive Dahl Salt-Sensitive Rats

2000 • 71 citations

Gene Transfer of Calcitonin Gene–Related Peptide Prevents Vasoconstriction After Subarachnoid Hemorrhage

2000 • 70 citations

RETRACTED: Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy

1998 • 62 citations

Adenoviral Expression of a Urokinase Receptor–Targeted Protease Inhibitor Inhibits Neointima Formation in Murine and Human Blood Vessels

2001 • 62 citations

Improvements in adenoviral vector technology: overcoming barriers for gene therapy

2000 • 56 citations

Losartan Versus Gene Therapy

1997 • 54 citations

Gene delivery and gene therapy with herpes simplex virus-based vectors

2001 • 53 citations

p27-p16 Fusion Gene Inhibits Angioplasty-Induced Neointimal Hyperplasia and Coronary Artery Occlusion

2001 • 46 citations

Sustained Inhibition of Angiotensin I–Converting Enzyme (ACE) Expression and Long-Term Antihypertensive Action by Virally Mediated Delivery of ACE Antisense cDNA

1999 • 42 citations

Gene therapy attenuates the elevated blood pressure and glucose intolerance in an insulin-resistant model of hypertension

2001 • 42 citations

Adenovirus-mediated kallikrein gene delivery attenuates hypertension and protects against renal injury in deoxycorticosterone-salt rats

1999 • 39 citations

Prevention of Restenosis by Gene Therapy

1997 • 38 citations

Expression of exogenous tissue factor pathway inhibitor in vivo suppresses thrombus formation in injured rabbit carotid arteries

2001 • 38 citations

Direct intra-cardiomuscular transfer of β2-adrenergic receptor gene augments cardiac output in cardiomyopathic hamsters

2000 • 32 citations

Adenoviral gene transfer of basic fibroblast growth factor promotes angiogenesis in rat brain

2000 • 32 citations

Recent advances, prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy.

1998 • 30 citations

Gene Therapy for Treatment of Cerebral Ischemia Using Defective Herpes Simplex Viral Vectors

2001 • 30 citations

In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI

2001 • 30 citations

Inability to Induce Hypertension in Normotensive Rat Expressing AT ₁ Receptor Antisense

2000 • 28 citations

Angiotensin I–Converting Enzyme Antisense Gene Therapy Causes Permanent Antihypertensive Effects in the SHR

2000 • 25 citations

Retroviral vectors

2000 • 21 citations

Human Tissue Kallikrein Attenuates Hypertension and Secretes into Circulation and Urine After Intramuscular Gene Delivery in Hypertensive Rats

1999 • 19 citations

The Potential Role of Antisense Oligodeoxynucleotide Therapy for Cardiovascular Disease

2000 • 15 citations

Prevention of restenosis using the gene for cecropin complexed with DOCSPER liposomes under optimized conditions

2005 • 13 citations

Gene therapy in heart disease

2001 • 9 citations

Antisense oligonucleotides strategy in the treatment of hypertension.

2001 • 8 citations

Gene Therapy for Coronary Artery Disease

2020 • 3 citations