Population pharmacokinetics and pharmacodynamics of oral etoposide

Carboplatin dosage: prospective evaluation of a simple formula based on renal function.

1989 • 1,831 citations

Creatinine Clearance: Bedside Estimate

1973 • 489 citations

Conventional Compared with Individualized Chemotherapy for Childhood Acute Lymphoblastic Leukemia

1998 • 487 citations

A randomized trial to evaluate the effect of schedule on the activity of etoposide in small-cell lung cancer.

1989 • 467 citations

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.

1998 • 420 citations

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

1977 • 390 citations

Relationships between carboplatin exposure and tumor response and toxicity in patients with ovarian cancer.

1992 • 369 citations

Effects of aging on the renal glomerulus

1986 • 354 citations

Pharmacodynamics in cancer therapy.

1990 • 135 citations

Principles of Antineoplastic Drug Development and Pharmacology

1996 • 113 citations

Pharmacokinetics of etoposide in patients with abnormal renal and hepatic function.

1986 • 109 citations

Predicting etoposide toxicity: relationship to organ function and protein binding.

1996 • 102 citations

Adaptive control of etoposide administration: Impact of interpatient pharmacodynamic variability

1989 • 94 citations

Etoposide pharmacokinetics in patients with normal and abnormal organ function.

1986 • 94 citations

Relation of systemic exposure to unbound etoposide and hematologic toxicity

1991 • 92 citations

Changes in the clearance of total and unbound etoposide in patients with liver dysfunction.

1990 • 83 citations

Altered protein binding of etoposide in patients with cancer

1989 • 80 citations

Dose Versus pharmacokinetics for predicting tolerance to 5‐day continuous infusion of 5‐FU

1988 • 73 citations

Etoposide kinetics in patients with obstructive jaundice.

1990 • 70 citations

Population pharmacokinetics of total and unbound etoposide

1997 • 69 citations

Clinical activity of chronic oral etoposide in previously treated metastatic breast cancer.

1994 • 62 citations

Variability in the pharmacokinetics of epirubicin: a population analysis

1992 • 56 citations

Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma

1999 • 52 citations

Population kinetics and conditional assessment of the optimal dosage regimen using the P-PHARM software package.

1994 • 47 citations

The effect of dose on the bioavailability of oral etoposide: confirmation of a clinically relevant observation

1989 • 41 citations

Ifosfamide in non-small cell lung cancer: a review.

1992 • 41 citations

The pharmacology of intravenous and oral etoposide

1991 • 41 citations

Phase II study of oral VP-16-213 in hepatocellular carcinoma

1981 • 34 citations

Determination of unbound etoposide concentration in ultrafiltered plasma by high-performance liquid chromatography with fluorimetric detection

1996 • 31 citations

Long-term oral etoposide in metastatic breast cancer: clinical and pharmacokinetic results

1993 • 31 citations

Therapeutic monitoring of continuous infusion etoposide in small-cell lung cancer.

1996 • 30 citations

Chronic oral etoposide in small-cell lung cancer: Clinical and pharmacokinetic results

1993 • 29 citations

A limited sampling model for the pharmacokinetics of etoposide given orally

1993 • 29 citations

Phase I pharmacokinetics and limited sampling strategies for the bioreductive alkylating drug EO9

1996 • 27 citations

Pharmacokinetics and pharmacodynamics of prolonged oral etoposide in women with metastatic breast cancer

1995 • 26 citations

Relation between unbound plasma concentrations and toxicity in a prolonged oral etoposide schedule

1998 • 23 citations

Population Pharmacokinetics of Mitoxantrone Performed by a NONMEM Method

1989 • 20 citations

A randomised, concentration-controlled, comparison of standard (5-day) vs. prolonged (15-day) infusions of etoposide phosphate in small-cell lung cancer

1998 • 19 citations

Therapeutic drug monitoring of 21-day oral etoposide in patients with advanced non-small cell lung cancer.

1998 • 18 citations

Oral etoposide in small cell lung cancer.

1992 • 10 citations

Evaluation of oral etoposide in patients with metastatic gastric carcinoma: a preliminary report.

1992 • 3 citations

Pharmacokinetics and pharmacodynamics of prolonged oral etoposide in women with metastatic breast cancer

1995 • 2 citations