Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Genomic sequencing.

1984 • 8,343 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

Lipoprotein receptors and cholesterol homeostasis

1983 • 755 citations

The biochemistry of glycoproteins and proteoglycans

1980 • 651 citations

Base sequence studies of 300 nucleotide renatured repeated human DNA clones

1981 • 605 citations

Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

1983 • 548 citations

Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains

1985 • 453 citations

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

1978 • 430 citations

Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

1982 • 378 citations

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

1981 • 359 citations

Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.

1981 • 318 citations

Human Apolipoprotein B: Structure of Carboxyl-Terminal Domains, Sites of Gene Expression, and Chromosomal Localization

1985 • 280 citations

Visualization of lipoprotein receptors by ligand blotting.

1983 • 273 citations

The LDL receptor locus in familial hypercholesterolemia: Multiple mutations disrupt transport and processing of a membrane receptor

1983 • 261 citations

Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

1981 • 254 citations

Identification of a Nondeletion Defect in α-Thalassemia

1977 • 194 citations

Lambda Charon vectors (Ch32, 33, 34 and 35) adapted for DNA cloning in recombination-deficient hosts

1983 • 191 citations

Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.

1986 • 177 citations

Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein.

1980 • 171 citations

Exon-Alu recombination deletes 5 kilobases from the low density lipoprotein receptor gene, producing a null phenotype in familial hypercholesterolemia.

1986 • 168 citations

Uptake of canine beta-very low density lipoproteins by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor.

1986 • 123 citations

Isolation of the bacteriophage lambda A-gene protein.

1975 • 102 citations

Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages.

1986 • 87 citations

Molecular weights of apoprotein B obtained from human low-density lipoprotein (apoprotein B-PI) and from rat very low density lipoprotein (apoprotein B-PIII)

1985 • 59 citations