Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Chronic catheterization of the spinal subarachnoid space

1976 • 2,244 citations

Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

1992 • 725 citations

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

1992 • 651 citations

Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin

1987 • 545 citations

Comparison of the Antinociceptive Effects of Pre- and Posttreatment with Intrathecal Morphine and MK801, an NMDA Antagonist, on the Formalin Test in the Rat

1992 • 354 citations

Pharmacology of the Spinal Action of Ketorolac, Morphine, ST-91, U50488H, and L-PIA on the Formalin Test and an Isobolographic Analysis of the NSAID Interaction

1993 • 279 citations

Dissociation Between the Antinociceptive and Anti-Inflammatory Effects of the Nonsteroidal Anti-Inflammatory Drugs

1991 • 275 citations

Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain

1992 • 178 citations

Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction

1991 • 175 citations

Spontaneous and evoked release of prostaglandins from frog spinal cord

1966 • 174 citations

Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

1991 • 154 citations

Acetylsalicylic Acid. New Uses for an Old Drug.

1982 • 112 citations

Pure Enantiomers of 2‐Arylpropionic Acids: Tools in Pain Research and Improved Drugs in Rheumatology

1992 • 84 citations

Noxious stimulus-induced increase in spinal prostaglandin E2 is noradrenergic terminal-dependent

1990 • 67 citations

Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo

1991 • 46 citations

Correlation between antiinflammatory activity and inhibition of prostaglandin biosynthesis induced by various non-steroidal antiinflammatory agents.

1979 • 24 citations