Post-translational processing events in the secretion pathway of human protein C, a complex vitamin K-dependent antithrombotic factor.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Human Plasma Protein C

1979 • 511 citations

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1982 • 385 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme

1982 • 308 citations

Current Advances in Vitamin K Research

1990 • 264 citations

Expression, purification, and characterization of recombinant gamma-carboxylated factor IX synthesized in Chinese hamster ovary cells.

1986 • 228 citations

Cloning and Expression of the cDNA for Human γ-glutamyl Carboxylase

1991 • 204 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.

1981 • 201 citations

Recognition site directing vitamin K-dependent γ-carboxylation resides on the propeptide of factor IX

1987 • 199 citations

The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors.

1985 • 195 citations

Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states.

1986 • 172 citations

The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody.

1988 • 156 citations

Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin

1991 • 147 citations

Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites.

1990 • 141 citations

Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid.

1983 • 127 citations

Propeptide of human protein C is necessary for .gamma.-carboxylation

1987 • 121 citations

Calcium binding to the epidermal growth factor homology region of bovine protein C.

1988 • 99 citations

Beta-hydroxyaspartic acid in the first epidermal growth factor-like domain of protein C. Its role in Ca2+ binding and biological activity.

1988 • 98 citations

Human hepatoma cells secrete single chain factor X, prothrombin, and antithrombin III

1984 • 97 citations

Vitamin K dependent carboxylase: subcellular location of the carboxylase and enzymes involved in Vitamin K metabolism in rat liver

1980 • 96 citations

Expression of active human clotting factor IX from recombinant DNA clones in mammalian cells

1985 • 94 citations

Active γ-carboxylated human factor IX expressed using recombinant DNA techniques

1985 • 91 citations

Post-translational modifications of proteins: some problems left to solve

1989 • 86 citations

Expression of active human factor IX in transfected cells

1985 • 82 citations

[26] Protein C

1981 • 67 citations

Protein C and related anticoagulants

1990 • 52 citations

Posttranslational Covalent Modifications of Proteins

1983 • 47 citations

Vitamin K-dependent carboxylase: possible role of the substrate "propeptide" as an intracellular recognition site.

1987 • 42 citations

Report of workshop on expression of vitamin k-dependent proteins in bacterial and mammalian cells Madison, Wisconsin, USA, April, 1986

1986 • 30 citations