N-acetylaspartate in the vertebrate brain: metabolism and function.

Interplay between Cortical Spreading Depolarization and Seizures

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An Energy Budget for Signaling in the Grey Matter of the Brain

2001 • 3,148 citations

Extracellular space structure revealed by diffusion analysis

1998 • 876 citations

N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain

1989 • 775 citations

N -Acetylaspartate in neuropsychiatric disorders

1995 • 422 citations

Regional Age Dependence of Human Brain Metabolites from Infancy to Adulthood as Detected by Quantitative Localized Proton MRS

1999 • 309 citations

Intraneuronal N‐acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin‐associated aspartoacylase

2001 • 299 citations

Heterotetrameric Composition of Aquaporin-4 Water Channels

1999 • 242 citations

Functions of N‐Acetyl‐<scp>l</scp>‐Aspartate and N‐Acetyl‐<scp>l</scp>‐Aspartylglutamate in the Vertebrate Brain

2000 • 238 citations

N-Acetylaspartate Reduction as a Measure of Injury Severity and Mitochondrial Dysfunction Following Diffuse Traumatic Brain Injury

2001 • 215 citations

The human Na⁺–glucose cotransporter is a molecular water pump

1998 • 187 citations

Evidence supporting a role for N-acetyl-l-aspartate as a molecular water pump in myelinated neurons in the central nervous system

2002 • 180 citations

Cerebral metabolism of [1,2‐¹³C₂]glucose and [U‐¹³C₄]3‐hydroxybutyrate in rat brain as detected by ¹³C NMR spectroscopy

1993 • 160 citations

Direct determination of the N-acetyl-l-aspartate synthesis rate in the human brain by 13C MRS and [1-13C]glucose infusion

2001 • 154 citations

Extracellular–Intracellular Distribution of Glucose and Lactate in the Rat Brain Assessed Noninvasively by Diffusion-Weighted ¹H Nuclear Magnetic Resonance Spectroscopy In Vivo

2000 • 151 citations

A Novel Role of Vasopressin in the Brain: Modulation of Activity-Dependent Water Flux in the Neocortex

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Biochemical markers of intelligence: a proton MR spectroscopy study of normal human brain

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Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study

1993 • 131 citations

Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system

2000 • 126 citations

Accumulation of N‐Acetyl‐L‐Aspartate in the Brain of the Tremor Rat, a Mutant Exhibiting Absence‐Like Seizure and Spongiform Degeneration in the Central Nervous System

2000 • 110 citations

Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy?

2001 • 110 citations

Expression of Aspartoacylase Activity in Cultured Rat Macroglial Cells Is Limited to Oligodendrocytes

1999 • 100 citations

Observed BOLD effects on cerebral metabolite resonances in human visual cortex during visual stimulation: A functional ¹H MRS study at 4 T

2001 • 87 citations

Water transport by the human Na⁺‐coupled glutamate cotransporter expressed in Xenopus oocytes

2001 • 84 citations

Isotonic transport by the Na⁺‐glucose cotransporter SGLT1 from humans and rabbit

2001 • 82 citations

Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain.

2000 • 82 citations

Aquaporin-4-containing astrocytes sustain a temperature- and mercury-insensitive swelling in vitro

2000 • 81 citations

AMIDOHYDROLASES OF BRAIN;¹ ENZYMATIC HYDROLYSIS OF N‐ACETYL‐<scp>l</scp>‐ASPARTATE AND OTHER N‐ACYL‐<scp>l</scp>‐AMINO ACIDS

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Developmental and regional distribution of aspartoacylase in rat brain tissue

2001 • 77 citations

Transient Elevation of Interstitial N‐Acetylaspartate in Reversible Global Brain Ischemia

1997 • 68 citations

Canavan disease

1997 • 64 citations

Myths of Neuropsychology: Intelligence, Neurometabolism, and Cognitive Ability

2000 • 59 citations

Effects of insulin and‐like growth factor (IGF‐I)on oligodendrocyte‐enriched glial culture

1988 • 59 citations

Astroglia Contain a Specific Transport Mechanism for N‐Acetyl‐<scp>l</scp>‐Aspartate

1999 • 55 citations

A Review of Phylogenetic and Metabolic Relationships Between the Acylamino Acids, N‐Acetyl‐<scp>l</scp>‐Aspartic Acid and N‐Acetyl‐<scp>l</scp>‐Histidine, in the Vertebrate Nervous System

1997 • 51 citations

Canavan's Spongiform Leukodystrophy : A Clinical Anatomy of a Genetic Metabolic CNS Disease

2000 • 50 citations

Vesicular osmometers, vasopression secretion and aquaporin-4:

1998 • 50 citations

Function of theN-acetyl-l-histidine system in the vertebrate eye

1998 • 47 citations

Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures

1987 • 46 citations

Molecular water pumps

2008 • 45 citations

General models for water transport across leaky epithelia

2002 • 44 citations

Mast Cells Contain Large Quantities of Secretagogue‐Sensitive N‐Acetylaspartate

1997 • 43 citations

The existence of molecular water pumps in the nervous system: a review of the evidence

1999 • 42 citations

Conransporters as molecular water pumps

2002 • 42 citations

Hypoosmolarity induces an increase of extracellular N-acetylaspartate concentration in the rat striatum.

1998 • 30 citations

Evaluation of radiolabeled acetate and fluoroacetate as potential tracers of cerebral oxidative metabolism

1990 • 29 citations

Cerebral metabolism of [3H]-p-chloroamphetamine

1977 • 25 citations

Plasmolipin: The other myelin proteolipid. A review of studies on its structure, expression, and function

1994 • 20 citations

Neurological sequelae of end stage renal disease (ESRD)

1977 • 17 citations

Differential Expression of Carnosine, Homocarnosine and N-Acetyl-L-Histidine Hydrolytic Activities in Cultured Rat Macroglial Cells

2001 • 16 citations

Glial cell abnormalities in the CNS of the carbonic anhydrase II deficient mutant mouse

1993 • 16 citations

Identification of membrane‐bound carbonic anhydrase in white matter coated vesicles: The fate of carbonic anhydrase and other white matter coated vesicle proteins in triethyl tin‐induced leukoencephalopathy

1993 • 14 citations

Anoxia in vitro does not induce neuronal swelling or death

1996 • 14 citations

Effect of orotic acid on the metabolism of cerebral cortical astrocytes during hypoxia and reoxygenation: an NMR spectroscopy study.

1998 • 10 citations

Early postnatal muscle contractile activity regulates the carbonic anhydrase phenotype of proprioceptive neurons in young and mature mice: Evidence for a critical period in development

1996 • 6 citations