Promotion of Allograft Survival by CD4+CD25+ Regulatory T Cells: Evidence for In Vivo Inhibition of Effector Cell Proliferation

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 • 1,745 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

The Technique of Free Skin Grafting in Mammals

1951 • 760 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

1997 • 493 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 305 citations

Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

2000 • 294 citations

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection

2003 • 261 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

THE ROLE OF AFFERENT LYMPHATICS IN THE REJECTION OF SKIN HOMOGRAFTS

1968 • 224 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

2002 • 161 citations

Anergy and suppression regulate CD4+ T cell responses to a self peptide

2000 • 115 citations

CD25+ Immunoregulatory CD4 T Cells Mediate Acquired Central Transplantation Tolerance

2003 • 46 citations

Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells

1995 • 37 citations

A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice

1997 • 32 citations

Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice1

2003 • 11 citations

Regulatory CD4 sup sup CD25 sup sup T cells in prevention of allograft rejection

2003 • 8 citations