Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an “excited” state of GTPase is a control component of the system.

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Catecholamine-stimulated GTPase activity in turkey erythrocyte membranes

1976 • 623 citations

Cholera

1973 • 294 citations

Evidence for Interdependent Action of Glucagon and Nucleotides on the Hepatic Adenylate Cyclase System

1974 • 244 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

The hepatic adenylate cyclase system. I. Evidence for transition states and structural requirements for guanine nucloetide activiation

1975 • 171 citations

On the mechanism of activation of fat cell adenylate cyclase by guanine nucleotides. An explanation for the biphasic inhibitory and stimulatory effects of the nucleotides and the role of hormones.

1975 • 106 citations

The requirement of guanine nucleotides for glucagon stimulation of adenylate cyclase in rat liver plasma membranes.

1977 • 93 citations

Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.

1977 • 92 citations

Synergistic activation of adenylate cyclase by guanylyl imidophosphate and epinephrine

1976 • 91 citations

The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

1975 • 84 citations

Evidence for specific binding sites for guanine nucleotides in adipocyte and hepatocyte plasma membranes. A difference in fate of GTP and guanosine 5'-(beta, gamma-imino) triphosphate.

1975 • 79 citations

Reversible activation of hepatic adenylate cyclase by guanyl-5'-yl-(alpha,beta-methylene)diphosphonate and guanyl-5'-yl imidodiphosphate.

1977 • 22 citations

Guanosine 5′, α-β-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: Evidence against pyrophosphorylation mechanism

1977 • 20 citations