Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes

Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polycrylamide to nitrocellulose

1984 • 2,553 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Cytokine receptor signalling

1995 • 1,242 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

Dual Oncostatin M (OSM) Receptors

1996 • 371 citations

Interleukin‐6: Structure‐function relationships

1997 • 358 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.

1994 • 275 citations

Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction.

1993 • 267 citations

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.

1994 • 242 citations

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

1995 • 220 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Single‐step purification and structural characterization of human interleukin‐6 produced in Esherichia coli From a T7 RNA polymerase expression vector

1991 • 139 citations

Crystal structure of a cytokine-binding region of gp130

1998 • 125 citations

The family of the IL-6-Type cytokines: Specificity and promiscuity of the receptor complexes

1997 • 119 citations

Soluble Human Interleukin‐6 Receptor

1995 • 96 citations

Interleukin‐6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti‐gp130 monoclonal antibodies

1995 • 87 citations

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions

1998 • 80 citations

Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex

1997 • 73 citations

Interleukin-6 Family of Cytokines Induced Activation of Different Functional Sites Expressed by gp130 Transducing Protein

1996 • 69 citations

Analysis of the Human Interleukin-6/Human Interleukin-6 Receptor Binding Interface at the Amino Acid Level: Proposed Mechanism of Interaction

1997 • 62 citations

The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL‐6 and the IL‐6 receptor

1995 • 49 citations

The Unusual Species Cross-reactivity of the Leukemia Inhibitory Factor Receptor α-Chain Is Determined Primarily by the Immunoglobulin-like Domain

1997 • 42 citations