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Transforming Growth Factor β Activation of p44mapk in Proliferating Cultures of Epithelial Cells

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Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

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1992 • 190 citations

Involvement of extracellular signal-regulated kinase 2 and stress-activated protein kinase/Jun N-terminal kinase activation by transforming growth factor beta in the negative growth control of breast cancer cells.

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Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector

1998 • 164 citations

Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway

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Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3

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Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

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Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells

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Transforming growth factor beta 1 induces apoptotic cell death in cultured human gastric carcinoma cells.

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Characterization of Functional Domains within Smad4/DPC4

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A Dominant Inhibitory Mutant of the Type II Transforming Growth Factor β Receptor in the Malignant Progression of a Cutaneous T-Cell Lymphoma

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Restoration of transforming growth factor beta signaling pathway in human prostate cancer cells suppresses tumorigenicity via induction of caspase-1-mediated apoptosis.

1999 • 143 citations

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

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Cooperative Binding of Smad Proteins to Two Adjacent DNA Elements in the Plasminogen Activator Inhibitor-1 Promoter Mediates Transforming Growth Factor β-induced Smad-dependent Transcriptional Activation

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Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines.

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Transforming Growth Factor-β Signaling in Epithelial Cells

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A Novel ets-related Transcription Factor, ERT/ESX/ESE-1, Regulates Expression of the Transforming Growth Factor-β Type II Receptor

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Induction of transforming growth factor-β autocrine activity by all-trans-retinoic acid and 1α,25-dihydroxyvitamin D3 in NRP-152 rat prostatic epithelial cells

1996 • 103 citations

Transforming Growth Factor-β-Mediated Apoptosis in the Ramos B-Lymphoma Cell Line Is Accompanied by Caspase Activation and Bcl-XLDownregulation

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Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells

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Loss of responsiveness to transforming growth factor beta induces malignant transformation of nontumorigenic rat prostate epithelial cells.

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Reduced levels of transforming growth factor beta receptor type II in human prostate cancer: an immunohistochemical study.

1996 • 84 citations

Inhibition by dexamethasone of transforming growth factor ?1,-induced apoptosis in rat hepatoma cells: A possible association with Bcl-xL induction

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Role for Bcl-xLin the Regulation of Apoptosis by EGF and TGFβ1 in c-myc Overexpressing Mammary Epithelial Cells

1996 • 75 citations

Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells.

1997 • 66 citations

Induction of Transforming Growth Factor-β Receptor Type II Expression in Estrogen Receptor-positive Breast Cancer Cells through SP1 Activation by 5-Aza-2′-deoxycytidine

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Apoptosis of human myeloid leukemia cells induced by an inhibitor of protein phosphatases (okadaic acid) is prevented by Bcl-2 and Bcl-XL

1997 • 45 citations

The Death Inhibitory Molecules CED-9 and CED-4L Use a Common Mechanism to Inhibit the CED-3 Death Protease

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Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?

1995 • 15 citations