Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia.

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Brain Maps: Structure of the Rat Brain

1992 • 1,873 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

1999 • 977 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

Endotoxin signal transduction in macrophages

1996 • 803 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

1996 • 760 citations

CD14 Is a pattern recognition receptor

1994 • 706 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages.

1993 • 328 citations

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

1998 • 323 citations

Regulation of the Genes Encoding Interleukin‐6, Its Receptor, and gp130 in the Rat Brain in Response to the Immune Activator Lipopolysaccharide and the Proinflammatory Cytokine Interleukin‐1β

1997 • 312 citations

Activation of the adhesive capacity of CR3 on neutrophils by endotoxin: dependence on lipopolysaccharide binding protein and CD14.

1991 • 300 citations

Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?

1998 • 280 citations

An Essential Role of Interleukin-1β in Mediating NF-κB Activity and COX-2 Transcription in Cells of the Blood–Brain Barrier in Response to a Systemic and Localized Inflammation But Not During Endotoxemia

1999 • 279 citations

Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation

1993 • 223 citations

The Bacterial Endotoxin Lipopolysaccharide has the Ability to Target the Brain in Upregulating Its Membrane CD14 Receptor Within Specific Cellular Populations

1998 • 215 citations

Effects of Systemic Immunogenic Insults and Circulating Proinflammatory Cytokines on the Transcription of the Inhibitory Factor κBα Within Specific Cellular Populations of the Rat Brain

1999 • 178 citations

Differential distribution of exogenous BDNF, NGF, and NT‐3 in the brain corresponds to the relative abundance and distribution of high‐affinity and low‐affinity neurotrophin receptors

1995 • 170 citations

Bacterial Toxin‐Induced Cytokine Production Studied at the Single‐Cell Level

1992 • 164 citations

Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide.

1995 • 162 citations

Regulation of the Gene Encoding Tumor Necrosis Factor Alpha (TNF-α) in the Rat Brain and Pituitary in Response to Different Models of Systemic Immune Challenge

1999 • 140 citations

Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice.

1997 • 79 citations

Effect of lipopolysaccharide on the permeability and reactivity of the cerebral microcirculation: role of inducible nitric oxide synthase

1998 • 69 citations

TNF-alpha, IL-1 beta, and hepatocyte growth factor cooperate in stimulating specific acute phase plasma protein genes in rat hepatoma cells.

1993 • 62 citations

Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide

1997 • 39 citations

EFFECT OF RECOMBINANT INTERLEUKIN-1β ON MURINE CD14 GENE EXPRESSION IN VIVO

1998 • 30 citations