Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

2012 • 16,041 citations

The basics of epithelial-mesenchymal transition

2009 • 9,200 citations

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

2003 • 1,398 citations

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

2004 • 1,199 citations

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

2009 • 779 citations

Structure and Function of the Polymeric Mucins in Airways Mucus

2007 • 762 citations

The Pathology of Chronic Obstructive Pulmonary Disease

2008 • 734 citations

New insights into the immunology of chronic obstructive pulmonary disease

2011 • 685 citations

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

2011 • 570 citations

The airway epithelium: Structural and functional properties in health and disease

2003 • 566 citations

Regulation of immunological homeostasis in the respiratory tract

2008 • 508 citations

Mucins, Mucus, and Sputum

2009 • 486 citations

In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations

2004 • 356 citations

Airway Epithelial Repair, Regeneration, and Remodeling after Injury in Chronic Obstructive Pulmonary Disease

2006 • 305 citations

Number and Proliferation of Basal and Parabasal Cells in Normal Human Airway Epithelium

1998 • 261 citations

Biology of common beta receptor-signaling cytokines: IL-3, IL-5, and GM-CSF.

2003 • 261 citations

Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease

2007 • 241 citations

Mitochondrial Localization and Function of Heme Oxygenase-1 in Cigarette Smoke–Induced Cell Death

2006 • 211 citations

Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease

2010 • 211 citations

Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

2010 • 201 citations

Expression of Genes Involved in Oxidative Stress Responses in Airway Epithelial Cells of Smokers with Chronic Obstructive Pulmonary Disease

2006 • 201 citations

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

2010 • 195 citations

Airway mucus: The good, the bad, the sticky

2008 • 189 citations

Differential Recognition of TLR-Dependent Microbial Ligands in Human Bronchial Epithelial Cells

2007 • 188 citations

Lung mucosal immunity: immunoglobulin-A revisited

2001 • 184 citations

Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells

2001 • 179 citations

Epithelial Mucin Stores Are Increased in the Large Airways of Smokers With Airflow Obstruction

2006 • 172 citations

Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease

2010 • 166 citations

Inflammatory Mediators in Chronic Obstructive Pulmonary Disease

2005 • 159 citations

Effect of Cigarette Smoke on the Permeability and IL-1 β and sICAM-1 Release from Cultured Human Bronchial Epithelial Cells of Never-Smokers, Smokers, and Patients with Chronic Obstructive Pulmonary Disease

2000 • 155 citations

Role of matrix metalloproteinases in the development of airway inflammation and remodeling

2005 • 153 citations

DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

2013 • 128 citations

Cigarette smoke irreversibly modifies glutathione in airway epithelial cells

2007 • 128 citations

NF-κB Mediates IL-1β– and IL-17A–Induced MUC5B Expression in Airway Epithelial Cells

2010 • 117 citations

Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production

2007 • 113 citations

Airway inflammation in chronic obstructive pulmonary disease

2003 • 104 citations

Interleukin-1β–Induced Mucin Production in Human Airway Epithelium Is Mediated by Cyclooxygenase-2, Prostaglandin E₂Receptors, and Cyclic AMP-Protein Kinase A Signaling

2004 • 104 citations

Induction of Inflammatory Mediators in Human Airway Epithelial Cells by Lipid Ozonation Products

1999 • 103 citations

Rhinovirus-Induced Barrier Dysfunction in Polarized Airway Epithelial Cells Is Mediated by NADPH Oxidase 1

2011 • 101 citations

Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia

2004 • 99 citations

Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution

2009 • 99 citations

Could the airway epithelium play an important role in mucosal immunoglobulin A production?

1999 • 93 citations

New Pharmacotherapy for Airway Mucus Hypersecretion in Asthma and COPD: Targeting Intracellular Signaling Pathways

2010 • 93 citations

Arylhydrocarbon receptor (AhR) activation in airway epithelial cells induces MUC5AC via reactive oxygen species (ROS) production

2010 • 80 citations

Hyaluronan Fragments/CD44 Mediate Oxidative Stress–Induced MUC5B Up-Regulation in Airway Epithelium

2008 • 77 citations

Relationship of Airway Epithelial Ion Transport to Chronic Bronchitis

2004 • 69 citations

Lung Injury and Cancer

2010 • 68 citations

Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes

2010 • 66 citations

Down-regulated Peroxisome Proliferator-activated Receptor γ (PPARγ) in Lung Epithelial Cells Promotes a PPARγ Agonist-reversible Proinflammatory Phenotype in Chronic Obstructive Pulmonary Disease (COPD)

2013 • 64 citations

Leukotriene A₄Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness

2010 • 63 citations

TGF-β1 Induces Human Bronchial Epithelial Cell-to-Mesenchymal Transition in Vitro

2009 • 59 citations

Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells

2008 • 58 citations

Quercetin attenuates airway inflammation and mucus production induced by cigarette smoke in rats

2012 • 53 citations

Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

2014 • 52 citations

Peroxisome proliferator-activated receptor-γ inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells

2006 • 51 citations

Matrix Metalloproteinase-14 Mediates a Phenotypic Shift in the Airways to Increase Mucin Production

2009 • 50 citations

Epigenetic mechanisms in COPD: implications for pathogenesis and drug discovery

2014 • 50 citations

Involvement of type II pneumocytes in the pathogenesis of chronic obstructive pulmonary disease

2010 • 49 citations

Impact of Bronchial Epithelium on Dendritic Cell Migration and Function: Modulation by the Bacterial Motif KpOmpA

2006 • 44 citations

Cigarette smoke modulates PGE₂ and host defence against Moraxella catarrhalis infection in human airway epithelial cells

2010 • 36 citations

Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept

2014 • 36 citations

Lung Epithelial CCAAT/Enhancer-binding Protein-β Is Necessary for the Integrity of Inflammatory Responses to Cigarette Smoke

2011 • 33 citations

Epithelial cells, the "switchboard" of respiratory immune defense responses: effects of air pollutants

2012 • 31 citations

The effect of quercetin on human neutrophil elastase‐induced mucin5AC expression in human airway epithelial cells

2012 • 29 citations

Smoke Extract Impairs Adenosine Wound Healing. Implications of Smoke-Generated Reactive Oxygen Species

2013 • 23 citations

The role of reactive oxygen and nitrogen species in airway epithelial gene expression.

1998 • 23 citations

Ozone Alters the Distribution of β₁ Integrins in Cultured Primate Bronchial Epithelial Cells

1998 • 18 citations

Protective Effects of Sesaminol on BEAS-2B Cells Impaired by Cigarette Smoke Extract

2014 • 12 citations

Summary: Tissue Remodeling and Repair Mechanisms in Chronic Obstructive Pulmonary Disease

2006 • 2 citations