Site-directed mutagenesis of tyrosine hydroxylase. Role of serine 40 in catalysis.

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction

2013 • 1,306 citations

An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

1987 • 699 citations

Complete coding sequence of rat tyrosine hydroxylase mRNA.

1985 • 544 citations

A rapid and simple radioassay for tyrosine hydroxylase activity

1964 • 506 citations

Purification and characterization of tyrosine hydroxylase from a clonal pheochromocytoma cell line.

1980 • 292 citations

Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.

1986 • 243 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.

1990 • 224 citations

Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase.

1984 • 219 citations

Tyrosine hydroxylase in rat brain dopaminergic nerve terminals. Multiple-site phosphorylation in vivo and in synaptosomes.

1991 • 155 citations

Site-directed mutagenesis of serine 40 of rat tyrosine hydroxylase. Effects of dopamine and cAMP-dependent phosphorylation on enzyme activity.

1992 • 149 citations

Secretory granules of an anterior pituitary cell line, AtT-20, contain only mature forms of corticotropin and beta-lipotropin.

1981 • 105 citations

Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase.

1986 • 65 citations

Trans-synaptic regulation of tyrosine 3-mono-oxygenase biosynthesis in rat adrenal medulla

1977 • 57 citations

Site-specific phosphorylation of tyrosine hydroxylase after KCl depolarization and nerve growth factor treatment of PC12 cells.

1990 • 38 citations

Limited proteolysis of rat brain tyrosine hydroxylase defines an N-terminal region required for regulation of cofactor binding and directing substrate specificity.

1991 • 36 citations

Antibodies to a Synthetic Peptide Corresponding to a Ser‐40‐Containing Segment of Tyrosine Hydroxylase: Activation and Immunohistochemical Localization of Tyrosine Hydroxylase

1989 • 11 citations