High dose methotrexate with leucovorin rescue

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 • 1,702 citations

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

1975 • 676 citations

Plasma Creatinine Determination A New and Specific Jaffe Reaction Method

1965 • 572 citations

The clinical pharmacology of methotrexate.new applications of an old drug

1978 • 561 citations

Adjuvant Therapy of Cancer

1990 • 534 citations

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

1977 • 390 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

The Effectiveness of Combinations of Antileukemic Agents in Inducing and Maintaining Remission in Children with Acute Leukemia

1965 • 314 citations

Recent advances in the chemotherapy of metastatic osteogenic sarcoma

1972 • 276 citations

Combination cancer therapy: Presidential address.

1972 • 171 citations

Intrathecal Amethopterin in Neurological Manifestations of Leukemia

1958 • 132 citations

Weekly methotrexate-calcium leucovorin rescue: effect of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma.

1977 • 117 citations

Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

1966 • 112 citations

High-Dose Methotrexate With Folinic Acid in the Treatment of Advanced Non-Hodgkin Lymphoma Including CNS Involvement

1977 • 107 citations

"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.

1977 • 107 citations

Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.

1968 • 101 citations

The prevention of methotrexate toxicity by thymidine infusions in humans.

1977 • 91 citations

Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture.

1979 • 90 citations

A rapid and specific radioimmunoassay for methotrexate.

1975 • 84 citations

Methotrexate and citrovorum factor rescue in the management of childhood lymphosarcoma and reticulum cell sarcoma (non-Hodgkin's lymphomas).Prolonged Unmaintained Remissions

1976 • 70 citations

Enzymatic Cleavage of Methotrexate provides a Method for Prevention of Drug Toxicity

1972 • 67 citations

High-dose methotrexate in acute lymphocytic leukemia.

1977 • 63 citations

TECHNIQUES FOR STUDY OF RESISTANCE TO FOLIC ACID ANTAGONISTS.

1964 • 59 citations

Analysis of the cytotoxic determinants for methotrexate (NSC 740): a role for 'free' intracellular drug

1975 • 42 citations

New Treatment Schedule With Improved Survival in Childhood Leukemia

1965 • 39 citations

Flow microfluorometric patterns of human bone marrow and tumor cells in response to cancer chemotherapy.

1976 • 37 citations

Phase II clinical trial with high-dose methotrexate therapy and citrovorum factor rescue.

1978 • 34 citations

Adjuvant Chemotherapy of Osteogenic Sarcoma: Progress and Perspectives 4

1978 • 24 citations

Clinical and pharmacological evaluation of triazinate in humans.

1976 • 21 citations