Structure-function analysis of the C-terminal segment of human interleukin-6.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Estimation of globular protein secondary structure from circular dichroism

1981 • 2,139 citations

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

1974 • 2,040 citations

The biology of interleukin-6

1989 • 1,964 citations

Interleukin-6: An Overview

1990 • 1,910 citations

The biology of interleukin-6

1989 • 1,459 citations

High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis

1989 • 1,357 citations

Interleukin-6 and Its Receptor: A Paradigm for Cytokines

1992 • 889 citations

Helix Signals in Proteins

1988 • 648 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Tests of the helix dipole model for stabilization of α-helices

1987 • 598 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

Functional discrimination between interleukin 6 and interleukin 1

1988 • 443 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.

1987 • 320 citations

Crystal Structure of a Synthetic Triple-Stranded α-Helical Bundle

1993 • 281 citations

Truncation of the c-myb gene by a retroviral integration in an interleukin 3-dependent myeloid leukemia cell line.

1986 • 204 citations

Constitutive production of interleukin‐6 and immunologic features in cardiac myxomas

1990 • 172 citations

Further studies of the helix dipole model: Effects of a free α‐NH₃⁺ or α‐COO⁻ group on helix stability

1989 • 145 citations

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants.

1990 • 138 citations

The Effect of T Cell Growth Factor on the Generation of Cytolytic T Cells

1978 • 113 citations

Structure‐function analysis of human interleukin‐6

1990 • 107 citations

Analysis of human IL-6 mutants expressed in Escherichia coli. Biologic activities are not affected by deletion of amino acids 1-28.

1989 • 91 citations

The three carboxy‐terminal amino acids of human interleukin‐6 are essential for its biological activity

1990 • 75 citations

Interleukin 1, tumor necrosis factor, and interleukin 6 as mediators of cartilage destruction

1989 • 75 citations

DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.

1990 • 64 citations

Identification of a receptor binding site in the carboxyl terminus of human interleukin-6.

1992 • 60 citations

Involvement of the Arg179 in the active site of human IL‐6

1993 • 56 citations

Evidence for the importance of a positive charge and an α‐helical structure of the C‐terminus for biological activity of human IL‐6

1991 • 56 citations

Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor

1989 • 38 citations

Role of disulfide bonds in biologic activity of human interleukin-6.

1991 • 34 citations

Role of a two-chain IL-6 receptor system in immune and hematopoietic cell regulation.

1992 • 31 citations

Enhanced hematopoietic growth factor production in an experimental myeloproliferative syndrome

1992 • 25 citations

A study on the renaturation of membrane proteins after solubilization in SDS or following polyacrylamide gel electrophoresis in SDS, with special reference to a phosphatase from acholeplasma laidlawii

1983 • 20 citations

Response of murine IL3-sensitive cell lines to cytokines of human and murine origin.

1989 • 19 citations

Construction and functional analysis of hybrid interleukin‐6 variants Characterization of the role of the C‐terminus for species specificity

1992 • 18 citations

Overexpression and structure-function analysis of a bioengineered IL-2/IL-6 chimeric lymphokine

1992 • 18 citations