Inhibition of Osteopenia by Biophysical Intervention

Lipid rafts and signal transduction

2000 • 6,079 citations

Sarcopenia: Origins and Clinical Relevance

1997 • 2,061 citations

Regulation of bone formation by applied dynamic loads.

1984 • 1,533 citations

Roentgenographic Assessment of the Biologic Fixation of Porous-Surfaced Femoral Components

1990 • 1,421 citations

Regulation of bone mass by mechanical strain magnitude

1985 • 1,285 citations

A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses

1994 • 1,229 citations

Adaptive bone-remodeling theory applied to prosthetic-design analysis

1987 • 1,106 citations

Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound.

1994 • 948 citations

Static vs dynamic loads as an influence on bone remodelling

1984 • 859 citations

Humeral hypertrophy in response to exercise

1977 • 815 citations

Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model.

1994 • 804 citations

Bone mineral loss and recovery after 17 weeks of bed rest

1990 • 769 citations

Effect of Starting Age of Physical Activity on Bone Mass in the Dominant Arm of Tennis and Squash Players

1995 • 741 citations

Mechanosensitive ion channels

1990 • 721 citations

Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo

2000 • 708 citations

Low mechanical signals strengthen long bones

2001 • 703 citations

Mechanical stress mechanisms and the cell. An endothelial paradigm.

1993 • 636 citations

Biomechanics of Mammalian Terrestrial Locomotion

1990 • 558 citations

An approach for time‐dependent bone modeling and remodeling—theoretical development

1990 • 541 citations

Osteoregulatory nature of mechanical stimuli: Function as a determinant for adaptive remodeling in bone

1987 • 500 citations

Limb Mechanics as A Function of Speed and Gait: A Study of Functional Strains in the Radius and Tibia of Horse and Dog

1982 • 498 citations

Mechanically adaptive bone remodelling

1982 • 483 citations

The influence of strain rate on adaptive bone remodelling

1982 • 474 citations

Transport mechanism operating between blood supply and osteocytes in long bones

1977 • 441 citations

Functional adaptation of bone to increased stress. An experimental study.

1979 • 411 citations

Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling

1984 • 410 citations

Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains

2000 • 389 citations

Effects of resistance and endurance exercise on bone mineral status of young women: A randomized exercise intervention trial

1992 • 384 citations

Fatigue Behavior of Adult Cortical Bone: The Influence of Mean Strain and Strain Range

1981 • 356 citations

Gymnasts exhibit higher bone mass than runners despite similar prevalence of amenorrhea and oligomenorrhea

1995 • 329 citations

Quantity and Quality of Trabecular Bone in the Femur Are Enhanced by a Strongly Anabolic, Noninvasive Mechanical Intervention

2002 • 327 citations

Biologic significance of piezoelectricity

1967 • 327 citations

The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low‐magnitude mechanical stimuli

2001 • 309 citations

Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways

2001 • 308 citations

Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone

2002 • 305 citations

A unifying principle relating stress to trabecular bone morphology

1986 • 299 citations

Bone Mass in Lifetime Tennis Athletes

1980 • 298 citations

Perspectives: bone's mechanical usage windows

1992 • 294 citations

Low‐Magnitude Mechanical Loading Becomes Osteogenic When Rest Is Inserted Between Each Load Cycle

2002 • 280 citations

Suppression of the osteogenic response in the aging skeleton

1992 • 269 citations

Skeletal strain and the functional significance of bone architecture

1984 • 262 citations

Functional Gap Junctions Between Osteocytic and Osteoblastic Cells

2000 • 261 citations

Beneficial effects of electromagnetic fields

1993 • 261 citations

A noninvasive, in vivo model for studying strain adaptive bone modeling

1991 • 241 citations

Strain Gradients Correlate with Sites of Periosteal Bone Formation

1997 • 239 citations

Bone-mineral density in children and adolescents who have spastic cerebral palsy.

1995 • 233 citations

Promotion of Bony Ingrowth by Frequency-Specific, Low-Amplitude Mechanical Strain

1994 • 228 citations

Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology

1998 • 224 citations

Bone formation and repair

1998 • 217 citations

A comparison of cortical bone atrophy secondary to fixation with plates with large differences in bending stiffness

1976 • 199 citations

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

1998 • 191 citations

Noise-enhanced balance control in older adults

2002 • 190 citations

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain

1996 • 188 citations

Trabecular bone remodeling: An experimental model

1991 • 182 citations

The effect of low-frequency electrical fields on osteogenesis.

1992 • 179 citations

Functional strains and cortical bone adaptation: Epigenetic assurance of skeletal integrity

1990 • 177 citations

Mechanobiologic influences in long bone cross-sectional growth

1993 • 175 citations

Cell-to-cell communication in osteoblastic networks: Cell line–dependent hormonal regulation of gap junction function

1995 • 170 citations

Reaction of bone to mechanical stimuli. 3. Microstructure of compact bone of rabbit tibia after intermittent loading.

1972 • 170 citations

Prevention of osteoporosis by pulsed electromagnetic fields.

1989 • 166 citations

Induction of bone formation in rat tail vertebrae by mechanical loading

1993 • 157 citations

Multiple forms of mechanosensitive ion channels in osteoblast-like cells

1990 • 153 citations

Characterizing bone strain distributions in vivo using three triple rosette strain gages

1992 • 153 citations

Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli

2001 • 149 citations

Osteoarthritis, bone density, postural stability, and osteoporotic fractures: a population based study.

1995 • 144 citations

Toward an identification of mechanical parameters initiating periosteal remodeling: A combined experimental and analytic approach

1990 • 142 citations

Activation of Extracellular Signal–Regulated Kinase Is Involved in Mechanical Strain Inhibition of RANKL Expression in Bone Stromal Cells

2002 • 134 citations

Mechanical stresses and endochondral ossification in the chondroepiphysis

1988 • 134 citations

Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

1991 • 133 citations

Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life¹

2000 • 133 citations

Modulation of bone loss during calcium insufficiency by controlled dynamic loading

1986 • 127 citations

Mechanical and electrical interactions in bone remodeling

1997 • 127 citations

Changes in Postural Muscle Dynamics as a Function of Age

1999 • 126 citations

A fiber matrix model for fluid flow and streaming potentials in the canaliculi of an osteon

1994 • 126 citations

Differentiation of the Bone-Tissue Remodeling Response to Axial and Torsional Loading in the Turkey Ulna*†

1996 • 125 citations

Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus

1995 • 110 citations

Bone Strain in the Tibia During Normal Quadrupedal Locomotion

1970 • 108 citations

The clinical results and basic science of total hip arthroplasty with porous-coated prostheses.

1993 • 103 citations

Osteoclastogenesis is repressed by mechanical strain in an in vitro model

1999 • 96 citations

Stress fields in the unplated and plated canine femur calculated from in vivo strain measurements

1981 • 91 citations

Piezoelectricity in tendon and bone

1975 • 85 citations

Uniformity of resorptive bone loss induced by disuse

1995 • 84 citations

Electric fields modulate bone cell function in a density-dependent manner

1993 • 84 citations

Selected Contribution: Osteocytes upregulate HIF-1α in response to acute disuse and oxygen deprivation

2001 • 84 citations

Strain Amplification in the Bone Mechanosensory System

1998 • 82 citations

Parathyroid hormone activation of stretch‐activated cation channels in osteosarcoma cells (UMR‐106.01)

1992 • 75 citations

Bone remodeling of diaphyseal surfaces by torsional loads: Theoretical predictions

1987 • 74 citations

Stretch-induced Inositol Trisphosphate and Tetrakisphosphate Production in Rat Cardiomyocytes

1993 • 68 citations

A comparative analysis of streaming potentials in vivo and in vitro

1992 • 67 citations

Structural changes in rat bone subjected to long-term, in vivo mechanical loading

1992 • 67 citations

Whole-body vibration in the skeleton: Development of a resonance-based testing device

1997 • 66 citations

Frequency specific modulation of bone adaptation by induced electric fields

1990 • 66 citations

Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories

1997 • 66 citations

Modulation of osteogenesis in fetal bone rudiments by mechanical stress in vitro

1991 • 61 citations

Journal of Bone and Mineral Research

1993 • 60 citations

Load-induced proteoglycan orientation in bone tissuein vivo andin vitro

1990 • 51 citations

The response of living bone to controlled time-varying loading: Method and preliminary results

1979 • 48 citations

Mechanically induced periosteal bone formation is paralleled by the upregulation of collagen type one mRNA in osteocytes as measured by In situ reverse transcript-polymerase chain reaction

1995 • 46 citations

Bone turnover and calcium metabolism during 20 days bed rest in young healthy males and females.

1994 • 42 citations

Low-power electromagnetic stimulation of osteotomized rabbit fibulae. A randomized, blinded study.

1994 • 42 citations

Recent bed rest results and countermeasure development at NASA.

1994 • 42 citations

Characterization of Genetic and Lifestyle Factors for Determining Variation in Body Mass Index, Fat Mass, Percentage of Fat Mass, and Lean Mass

2001 • 40 citations

Bone streaming potentials and currents depend on anatomical structure and loading orientation

1997 • 37 citations

Metabolic modulation of disuse osteopenia: Endocrine-dependent site specificity of bone remodeling

1990 • 37 citations

Streaming potentials in fluid-filled bone

1984 • 37 citations

Ceramic models for piezoelectricity in dry bone

1980 • 34 citations

The Plated Femur: Relationships Between the Changes in Bone Stresses and Bone Loss

1981 • 33 citations

Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy

1993 • 32 citations

Increased expression of matrix metalloproteinase‐1 in osteocytes precedes bone resorption as stimulated by disuse: Evidence for autoregulation of the cell's mechanical environment?

1999 • 32 citations

Biologic Modulation of Mechanical Influences in Bone Remodeling

1990 • 26 citations

A Histomorphometric Observation of Flows in Cortical Bone under Dynamic Loading

2000 • 26 citations

Electrophysiological responses of osteoclasts to hormones

1986 • 25 citations

Localization and effects of pituitary adenylate cyclase‐activating polypeptide (PACAP) in human penile erectile tissue

1994 • 25 citations

Influence of patient's weight on dual-photon absorptiometry and dual-energy X-ray absorptiometry measurements of bone mineral density

1993 • 20 citations

Bone Loss in Space: Shuttle/MIR Experience and Bed Rest Countermeasure Program

1999 • 12 citations

Biophysical Modulation of Cell and Tissue Structure and Function

1995 • 11 citations

Streaming Potential in Bone

1990 • 6 citations

Estimating the Risk of Fracture in Osteopenic Patients

1995 • 6 citations

DIE CHEMISCHE UNTERSUCHUNGEN DES DARMES:II. Mitteilung Durchblutungsversuche des Darmes mit Harnstoff

1934 • 1 citations