The Activation of Bovine Protein C by Factor Xa

Protein Purification by Affinity Chromatography

1970 • 2,809 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

1979 • 592 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

Preparation and properties of bovine factor VIII (antihemophilic factor)

1980 • 504 citations

Anticoagulant properties of bovine plasma protein C following activation by thrombin

1977 • 495 citations

The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V

1979 • 480 citations

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation.

1982 • 434 citations

The Conversion of Prothrombin to Thrombin

1974 • 366 citations

Basic Mechanisms in Blood Coagulation

1975 • 366 citations

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

1979 • 356 citations

Prothrombin structure, activation, and biosynthesis

1977 • 347 citations

Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 330 citations

Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.

1987 • 278 citations

Enzymes: Physical principles

1973 • 245 citations

Thrombin-catalyzed activation of single chain bovine factor V.

1979 • 229 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

[14] Thrombin

1976 • 214 citations

Interactions of a fluorescent active-site-directed inhibitor of thrombin: dansylarginine N-(3-ethyl-1,5-pentanediyl)amide

1979 • 213 citations

Proteolytic activation of protein C from bovine plasma

1976 • 211 citations

Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C.

1983 • 202 citations

[13] Prothrombin

1976 • 197 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 194 citations

Phospholipid-binding properties of bovine factor V and factor Va

1979 • 173 citations

Protein-C: biochemistry, physiology, and clinical implications

1983 • 169 citations

The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction.

1986 • 151 citations

Studies of the capacity of factor Xa to protect factor Va from inactivation by activated protein C.

1982 • 141 citations

Prothrombin is activated on vascular endothelial cells by factor Xa and calcium.

1983 • 134 citations

The binding of factor Va to phospholipid vesicles.

1988 • 125 citations

The effect of bovine thrombomodulin on the specificity of bovine thrombin.

1986 • 106 citations

Synthesis of coagulation factor V by cultured aortic endothelium

1984 • 102 citations

Reconstitution of rabbit thrombomodulin into phospholipid vesicles.

1987 • 99 citations

Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.

1984 • 96 citations

Characterization of two glycoprotein variants of bovine factor X and demonstration that the factor X zymogen contains two polypeptide chains

1972 • 94 citations

The binding of activated protein C to factors V and Va.

1986 • 91 citations

Proteolysis of factor Va by factor Xa and activated protein C.

1987 • 77 citations

[26] Protein C

1981 • 67 citations

Proteolytic alterations of factor Va bound to platelets.

1983 • 58 citations

Protein C in Thromboembolic Disease

1985 • 55 citations

A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo

1988 • 49 citations

Thrombomodulin

1987 • 48 citations

Studies of Factors V and VIII:C in an animal model of disseminated intravascular coagulation.

1984 • 46 citations

The Role of Endothelium in the Homeostatic Balance of Haemostasis

1985 • 42 citations

Inhibition by human thrombomodulin of factor Xa-mediated cleavage of prothrombin.

1986 • 35 citations

Control of Thrombin Mediated Cleavage of Protein S

1986 • 26 citations

Interaction of Thrombin with Thrombomodulin

1986 • 24 citations

An inhibitory monoclonal antibody to factor X that blocks prothrombin activation but not prothrombinase enzyme assembly

1988 • 18 citations

Complex Interaction between Factor V_a‐Light Chain and Thrombomodulin in the Regulation of Protein C Activation^a

1986 • 4 citations