Long-Term Transfer and Expression of the Human β-Globin Gene in a Mouse Transplant Model

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 637 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Construction and use of a safe and efficient amphotropic packaging cell line

1988 • 416 citations

Lineage-specific expression of a human β-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells

1988 • 341 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

A dominant chromatin-opening activity in 5′ hypersensitive site 3 of the human beta-globin locus control region.

1996 • 220 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.

1992 • 218 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.

1995 • 201 citations

Mutagenesis of retroviral vectors transducing human beta-globin gene and beta-globin locus control region derivatives results in stable transmission of an active transcriptional structure.

1994 • 162 citations

A majority of mice show long-term expression of a human beta-globin gene after retrovirus transfer into hematopoietic stem cells.

1989 • 153 citations

High-level beta-globin expression after retroviral transfer of locus activation region-containing human beta-globin gene derivatives into murine erythroleukemia cells.

1990 • 129 citations

Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice.

1988 • 119 citations

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.

1995 • 118 citations

Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer

1994 • 108 citations

A human beta-globin gene fused to the human beta-globin locus control region is expressed at high levels in erythroid cells of mice engrafted with retrovirus-transduced hematopoietic stem cells

1993 • 99 citations

Design of retrovirus vectors for transfer and expression of the human beta-globin gene

1988 • 96 citations

High-efficiency gene transfer to human hematopoietic cells maintained in long-term marrow culture [see comments]

1989 • 83 citations

Gene Transfer to Hematopoietic Cells

1996 • 79 citations

Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem cell factor plus granulocyte colony-stimulating factor

1994 • 62 citations

Preselection of transduced murine hematopoietic stem cell populations leads to increased long-term stability and expression of the human multiple drug resistance gene

1995 • 59 citations

Human somatic cell gene therapy

1996 • 46 citations

Mouse fetal liver cells lack functional amphotropic retroviral receptors

1994 • 41 citations

Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.

1995 • 39 citations

Changes in Globin Synthesis With Erythroid Cell Maturation in Sickle Thalassemia

1973 • 30 citations