Regulatory Effects of Endogenous Protease Inhibitors in Acute Lung Inflammatory Injury

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates

1980 • 1,991 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

The Lung: Scientific Foundations

1991 • 1,181 citations

Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 • 899 citations

Isolation, properties, and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase.

1986 • 477 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.

1995 • 434 citations

Cytokine regulation of metalloproteinase gene expression

1993 • 432 citations

Secretory Leukocyte Protease Inhibitor: A Macrophage Product Induced by and Antagonistic to Bacterial Lipopolysaccharide

1997 • 390 citations

Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes.

1994 • 294 citations

C5 Chemotactic Fragments Produced by an Enzyme in Lysosomal Granules of Neutrophils

1970 • 246 citations

Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.

1994 • 242 citations

Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat.

1989 • 207 citations

cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases.

1990 • 202 citations

Requirement and role of C5a in acute lung inflammatory injury in rats.

1996 • 196 citations

Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

1989 • 193 citations

Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases.

1997 • 177 citations

Requirement for C-X-C chemokines (macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant) in IgG immune complex-induced lung injury.

1997 • 176 citations

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

1981 • 171 citations

The effects of cytokines on metalloproteinase inhibitors (TIMP) and collagenase production by human chondrocytes and TIMP production by synovial cells and endothelial cells

1993 • 170 citations

Tissue distribution of antileukoprotease and lysozyme in humans.

1989 • 157 citations

Isolation and sequence of a human gene encoding a potent inhibitor of leukocyte proteases

1986 • 140 citations

Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.

1988 • 128 citations

Chemotactic Activity of Collagen-Like Polypeptides for Human Peripheral Blood Neutrophils

1986 • 121 citations

Structure and Characterization of the Human Tissue Inhibitor of Metalloproteinases-2 Gene

1996 • 119 citations

Neutrophil-mediated solubilization of the subendothelial matrix: oxidative and nonoxidative mechanisms of proteolysis used by normal and chronic granulomatous disease phagocytes.

1986 • 113 citations

Complex regulation of membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation by concanavalin A in MDA-MB-231 human breast cancer cells.

1995 • 109 citations

Immune complex-induced lung and dermal vascular injury. Differing requirements for tumor necrosis factor-alpha and IL-1.

1992 • 85 citations

In vivo suppression of immune complex-induced alveolitis by secretory leukoproteinase inhibitor and tissue inhibitor of metalloproteinases 2.

1993 • 82 citations

Identification of TIMP-2 in human alveolar macrophages. Regulation of biosynthesis is opposite to that of metalloproteinases and TIMP-1.

1992 • 76 citations

Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family

1994 • 69 citations

Neutrophil elastase increases secretory leukocyte protease inhibitor transcript levels in airway epithelial cells

1993 • 68 citations

Metalloproteinase inhibitors from bovine cartilage and body fluids

1984 • 62 citations

Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases-2

1992 • 62 citations

Tissue inhibitor of metalloproteinases-2 is expressed in the interstitial matrix in adult mouse organs and during embryonic development.

1997 • 57 citations

Recombinant human secretory leukocyte-protease inhibitor: in vitro properties, and amelioration of human neutrophil elastase-induced emphysema and secretory cell metaplasia in the hamster.

1990 • 57 citations

Antileukoprotease Is Associated with Elastin Fibers in the Extracellular Matrix of the Human Lung: An Immunoelectron Microscopic Study

1989 • 54 citations

The Cloning and Characterization of a Murine Secretory Leukocyte Protease Inhibitor cDNA

1997 • 52 citations

Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.

1996 • 50 citations

Neutrophil Response following Intratracheal Instillation of Collagen Peptides into Rat Lungs

1988 • 42 citations

Metalloproteinase domain structure, cellular invasion and metastasis

1994 • 42 citations

Human recombinant interleukin‐1α‐mediated stimulation of procollagenase production and suppression of biosynthesis of tissue inhibitor of metalloproteinases in rabbit uterine cervical fibroblasts

1988 • 41 citations

Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2

1992 • 39 citations

Inhibition of Lipopolysaccharide-induced Pulmonary Emphysema by Intratracheally Instilled Recombinant Secretory Leukocyte Proteinase Inhibitor

1993 • 37 citations

Cloning and Regulation of Rat Tissue Inhibitor of Metalloproteinases-2 in Osteoblastic Cells

1994 • 32 citations

Intravenous recombinant secretory leukoprotease inhibitor augments antineutrophil elastase defense

1992 • 29 citations

Cloning of the Rat Tissue Inhibitor of Metalloproteinases Type 2 (TIMP-2) Gene: Analysis of Its Expression in Normal and Transformed Thyroid Cells

1994 • 23 citations

Secretory leucocyte proteinase inhibitor is produced by human articular cartilage chondrocytes and intervertebral disc fibrochondrocytes

1993 • 23 citations

The rôle of proteases and antiproteases in bronchial secretions.

1987 • 21 citations

Expression of human mucous proteinase inhibitor in respiratory tract: a study by in situ hybridization.

1995 • 19 citations

Expression of serine proteinases and metalloproteinases in organ-cultured human skin. Altered levels in the presence of retinoic acid and possible relationship to retinoid-induced loss of epidermal cohesion.

1994 • 18 citations

Synthesis and refolding of human TIMP‐2 from E. coli, with specific activity for MMP‐2

1995 • 16 citations

Intratracheally-instilled antileukoprotease and α1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization

1994 • 11 citations

Antileukoprotease, its role in the human lung.

1988 • 10 citations

Chemotactic activity of elastin-derived peptides for human polymorphonuclear leukocytes and their effect on hydrogen peroxide and myeloperoxidase release.

1989 • 10 citations

Intratracheally-instilled antileukoprotease and α1-proteinase inhibitor: effect on human neutrophil elastase-induced experimental emphysema and pulmonary localization

1994 • 8 citations

Bronchial leukocyte proteinase inhibitor: Hydrodynamic properties and interaction with α2-macroglobulin-bound elastase

1988 • 2 citations