Inactivation of calcineurin by hydrogen peroxide and phenylarsine oxide

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

[11] Calculation of protein conformation from circular dichroism

1986 • 1,625 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex

1995 • 749 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

A Comparison between the Sulfhydryl Reductants Tris(2-carboxyethyl)phosphine and Dithiothreitol for Use in Protein Biochemistry

1999 • 454 citations

Statistical determination of the average values of the extinction coefficients of tryptophan and tyrosine in native proteins

1992 • 439 citations

Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site

1995 • 428 citations

Crystal Structure of the Catalytic Subunit of Human Protein Phosphatase 1 and its Complex with Tungstate

1995 • 418 citations

Protein phosphatases: recent progress.

1991 • 391 citations

Mechanism of Fe(III) – Zn(II) Purple Acid Phosphatase Based on Crystal Structures

1996 • 362 citations

Spectrophotometric assay of thiols

1987 • 301 citations

Superoxide dismutase protects calcineurin from inactivation

1996 • 270 citations

Identification of an autoinhibitory domain in calcineurin.

1990 • 268 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

Calcineurin

1999 • 217 citations

The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2

1998 • 217 citations

Functional domain structure of calcineurin A: mapping by limited proteolysis

1989 • 201 citations

The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions. Identification of calcineurin as a Zn and Fe metalloenzyme.

1984 • 160 citations

Enzymatic reduction-oxidation of protein disulfides by thioredoxin

1984 • 145 citations

Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 Å resolution with a μ-(hydr)oxo bridged di-iron center

1999 • 142 citations

Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes.

1994 • 141 citations

Calcineurin

1988 • 132 citations

Crystal structure of a mammalian purple acid phosphatase 1 1Edited by R. Huber

1999 • 129 citations

Regulation of calcineurin by metal ions. Mechanism of activation by Ni2+ and an enhanced response to Ca2+/calmodulin.

1984 • 121 citations

[20] Use of calmodulin affinity chromatography for purification of specific calmodulin-dependent enzymes

1983 • 107 citations

Characterization of Calcineurin in Human Neutrophils

1999 • 98 citations

Fas Ligand Induction in Human NK Cells Is Regulated by Redox Through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway

1999 • 95 citations

Anion binding to uteroferrin. Evidence for phosphate coordination to the iron(III) ion of the dinuclear active site and interaction with the hydroxo bridge

1990 • 82 citations

Calcineurin and vacuolar-type H⁺-ATPase modulate macrophage effector functions

1999 • 76 citations

Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells.

1996 • 59 citations

Properties of the Fe(II)-Fe(III) derivative of red kidney bean purple phosphatase. Evidence for a binuclear zinc-iron center in the native enzyme

1988 • 59 citations

Primary Structure, Expression and Developmental Regulation of a Dictyostelium Calcineurin A Homologue

1996 • 58 citations

Inhibition of coupling factor B activity by cadmium ion, arsenite-2,3-dimercaptopropanol, and phenylarsine oxide, and preferential reactivation by dithiols.

1981 • 58 citations

Evidence That Calcineurin Accommodates an Active Site Binuclear Metal Center

1995 • 54 citations

Evidence for Nonbridged Coordination of p-Nitrophenyl Phosphate to the Dinuclear Fe(III)−M(II) Center in Bovine Spleen Purple Acid Phosphatase during Enzymatic Turnover

1999 • 53 citations

Spectroscopic and Enzymatic Characterization of the Active Site Dinuclear Metal Center of Calcineurin: Implications for a Mechanistic Role

1997 • 50 citations

Nonradioactive Assay for Protein Phosphatase 2B (Calcineurin) Activity Using a Partial Sequence of the Subunit of cAMP-Dependent Protein Kinase as Substrate

1994 • 49 citations

[43] Purification of vicinal dithiol-containing proteins by arsenical-based affinity chromatography

1994 • 44 citations

Activation of brain calcineurin towards proteins containing Thr(P) and Ser(P) by Ca2+, calmodulin, Mg2+ and transition metal ions

1984 • 41 citations

Factors responsible for the Ca²⁺‐dependent inactivation of calcineurin in brain

1995 • 37 citations

[23] Purification and radioimmunoassay of calmodulin-dependent protein phosphatase from bovine brain

1983 • 35 citations

Selective Bridging of Bis-Cysteinyl Residues by Arsonous Acid Derivatives as an Approach to the Characterization of Protein Tertiary Structures and Folding Pathways by Mass Spectrometry

1998 • 32 citations

Modification of the calmodulin-stimulated phosphatase, calcineurin, by sulfhydryl reagents.

1986 • 27 citations

Effects of Sulfhydryl Reagents, Retinoids, and Solubilization on the Activity of Microsomal Retinol Dehydrogenase

1995 • 26 citations

Overexpression, purification and characterization of Dictyostelium calcineurin A

1997 • 25 citations

Quantitation of Hydrogen Peroxide Using Tris(2-carboxyethyl)phosphine

1996 • 22 citations

Characterization of the folding pathway of recombinant human macrophage-colony stimulating-factor β (rhM-CSF β) by bis-cysteinyl modification and mass spectrometry

1998 • 15 citations

[41] Tertiary structure-selective characterization ofprotein dithiol groups by phenylarsine oxide modification and mass spectrometric peptide mapping

1995 • 15 citations

Tyrosine phosphatase-dependent/tyrosine kinase-independent induction of nuclear factor-kappa B by tumor necrosis factor-alpha: effects on prostaglandin endoperoxide synthase-2 mRNA accumulation.

1998 • 13 citations

Effects of sulfhydryl agents, trifluoperazine, phosphatase inhibitors and tryptic proteolysis on calcineurin isolated from bovine cerebral cortex

1990 • 11 citations