Molecular Mechanisms for Lipopolysaccharide-induced Biphasic Activation of Nuclear Factor-κB (NF-κB)

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Perspectives in platelet-activating factor research.

1987 • 1,383 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

1997 • 1,159 citations

MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex

1997 • 1,104 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 • 844 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Possible new role for NF-κB in the resolution of inflammation

2001 • 741 citations

The evolution and genetics of innate immunity

2001 • 665 citations

Regulatory Functions of Phospholipase A2

1997 • 551 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

1995 • 253 citations

Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B

2000 • 228 citations

Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha.

1988 • 221 citations

Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.

1993 • 208 citations

The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence

2000 • 192 citations

Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules.

1995 • 172 citations

Platelet-activating Factor Induces NF-κB Activation through a G Protein-coupled Pathway

1995 • 154 citations

Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.

1994 • 149 citations

Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1.

1998 • 112 citations

Listeria monocytogenes infection of P388D ₁ macrophages results in a biphasic NF-κB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IκBα and IκBβ degradation

1997 • 97 citations

Platelet-activating factor (PAF-acether) enhances the concomitant production of tumour necrosis factor-alpha and interleukin-1 by subsets of human monocytes.

1991 • 93 citations

Selective Inhibitors of Cytosolic or Secretory Phospholipase A2 Block TNF-Induced Activation of Transcription Factor Nuclear Factor-κB and Expression of ICAM-1

1998 • 89 citations

Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways.

1997 • 82 citations

Augmentation of tumor metastasis by platelet-activating factor.

1996 • 82 citations

Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis

2000 • 79 citations

Rickettsia rickettsii infection of cultured human endothelial cells induces NF-kappaB activation

1997 • 71 citations

Involvement of nuclear factor-xB in platelet-activating factor-mediated tumor necrosis factor-α expression

1997 • 66 citations

1-O-Alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle

1985 • 60 citations

Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor

1995 • 57 citations

A Double-Blind Placebo-Controlled Study of an Infusion of Lexipafant (Platelet-Activating Factor Receptor Antagonist) in Patients with Severe Sepsis

2000 • 53 citations

Glucocorticoids prevent NF-κB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide

1999 • 45 citations

Modulation of lyso-platelet-activating factor:acetyl-CoA acetyltransferase from rat splenic microsomes. The role of calcium ions

1985 • 44 citations

Platelet-Activating Factor-Induced Early Activation of NF-κB Plays a Crucial Role for Organ Clearance of Candida albicans

2001 • 42 citations

PHOSPHOLIPASE A2INHIBITORS AND LEUKOTRIENE SYNTHESIS INHIBITORS BLOCK TNF-INDUCED NF-κB ACTIVATION

1999 • 34 citations

Cell-specific regulation of type II phospholipase A2 expression in rat mesangial cells.

1993 • 31 citations

Activation of NF- B and Immunoglobulin Expression in Response to Platelet-Activating Factor in a Human B Cell Line

1994 • 28 citations

Interleukin-1 and tumor necrosis factor are not synergistic for human synovial fibroblast PLA2 activation and PGE2 production

1988 • 26 citations

Selective involvement of reactive oxygen intermediates in platelet-activating factor-mediated activation of NF-kappaB.

2000 • 22 citations