Dantrolene Inhibition of Ryanodine Receptor Ca2+Release Channels

Calcium - a life and death signal

1998 • 2,040 citations

Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions

1997 • 690 citations

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

1995 • 551 citations

The sarcoplasmic reticulum Ca2+ channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states.

1997 • 549 citations

Rapid calcium release from cardiac sarcoplasmic reticulum vesicles is dependent on Ca2+ and is modulated by Mg2+, adenine nucleotide, and calmodulin.

1987 • 489 citations

Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function?

1996 • 400 citations

Bound and determined: A computer program for making buffers of defined ion concentrations

1992 • 335 citations

NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release

1995 • 319 citations

Genetics and pathogenesis of malignant hyperthermia

2000 • 296 citations

Multiple types of ryanodine receptor/Ca2+ release channels are differentially expressed in rabbit brain

1994 • 258 citations

Dantrolene

1986 • 252 citations

Caffeine and Halothane Sensitivity of Intracellular Ca2+ Release Is Altered by 15 Calcium Release Channel (Ryanodine Receptor) Mutations Associated with Malignant Hyperthermia and/or Central Core Disease

1997 • 249 citations

Calcium Release from Skeletal Muscle Sarcoplasmic Reticulum: Site of Action of Dantrolene Sodium?

1976 • 242 citations

Abnormal sarcoplasmic reticulum ryanodine receptor in malignant hyperthermia.

1988 • 238 citations

Dantrolene Inhibition of Sarcoplasmic Reticulum Ca2+Release by Direct and Specific Action at Skeletal Muscle Ryanodine Receptors

1997 • 202 citations

Molecular Identification of the Ryanodine Receptor Pore-forming Segment

1999 • 197 citations

Malignant Hyperthermia and Central Core Disease: Disorders of Ca2 Release Channels11In collaboration with The American Physiological Society, Thomas E. Andreoli, MD, Editor

1998 • 197 citations

Magnesium Inhibition of Ryanodine-Receptor Calcium Channels: Evidence for Two Independent Mechanisms

1997 • 189 citations

Dantrolene Dose Response in Awake Man

1983 • 173 citations

Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal IschemiaIn Vivoand to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

2000 • 169 citations

Functional Characterization of the Recombinant Type 3 Ca2+ Release Channel (Ryanodine Receptor) Expressed in HEK293 Cells

1997 • 162 citations

Differential Ca²⁺ sensitivity of skeletal and cardiac muscle ryanodine receptors in the presence of calmodulin

2000 • 137 citations

The mechanism of action of dantrolene sodium.

1977 • 137 citations

Dantrolene Is Cytoprotective in Two Models of Neuronal Cell Death

1996 • 135 citations

Effect of dantrolene sodium on calcium movements in single muscle fibres

1974 • 133 citations

Caffeine and excitation-contraction coupling in skeletal muscle: a stimulating story.

1999 • 124 citations

Tissue distribution of ryanodine receptor isoforms and alleles determined by reverse transcription polymerase chain reaction.

1994 • 118 citations

Potential for Pharmacology of Ryanadine Receptor/Calcium Release Channels^a

1998 • 117 citations

Inhibitory action of dantrolene on Ca-induced Ca2+ release from sarcoplasmic reticulum in guinea pig skeletal muscle

1990 • 97 citations

Modulation of Ca²⁺-gated cardiac muscle Ca²⁺-release channel (ryanodine receptor) by mono- and divalent ions

1998 • 89 citations

Identification of Dantrolene Binding Sites in Porcine Skeletal Muscle Sarcoplasmic Reticulum

1995 • 75 citations

HEK-293 cells possess a carbachol- and thapsigargin-sensitive intracellular Ca2+ store that is responsive to stop-flow medium changes and insensitive to caffeine and ryanodine

1999 • 62 citations

Role of Mg2+ in Ca2+-Induced Ca2+ Release through Ryanodine Receptors of Frog Skeletal Muscle: Modulations by Adenine Nucleotides and Caffeine

2000 • 59 citations

Seizure-Induced Cell Death Produced by Repeated Tetanic Stimulation In Vitro: Possible Role of Endoplasmic Reticulum Calcium Stores

1999 • 58 citations

Modulation of the Frequency of Spontaneous Sarcoplasmic Reticulum Ca2+ Release Events (Ca2+ Sparks) by Myoplasmic [Mg2+] in Frog Skeletal Muscle

1998 • 57 citations

Characterization of Recombinant Rabbit Cardiac and Skeletal Muscle Ca2+ Release Channels (Ryanodine Receptors) with a Novel [3H]Ryanodine Binding Assay

1998 • 51 citations

Clinical Effects of Intravenously Administered Dantrolene

1995 • 48 citations

[³H]Azidodantrolene: Synthesis and Use in Identification of a Putative Skeletal Muscle Dantrolene Binding Site in Sarcoplasmic Reticulum

1999 • 42 citations

Caffeine stimulation of malignant hyperthermia-susceptible sarcoplasmic reticulum Ca2+ release channel

1994 • 28 citations

Dantrolene -In vitro studies in malignant hyperthermia susceptible (MHS) and normal skeletal muscle

1984 • 26 citations

The Sarcoplasmic Reticulum Ca²⁺‐ATPase Is Depressed in Stunned Myocardium after Ischemia‐Reperfusion, but Remains Functionally Coupled to Sarcoplasmic Reticulum‐Bound Glycolytic Enzymes^a

1998 • 23 citations