Identification of Dantrolene Binding Sites in Porcine Skeletal Muscle Sarcoplasmic Reticulum

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia

1991 • 1,485 citations

Ryanodine Receptor/Ca2+ Release Channels and Their Regulation by Endogenous Effectors

1994 • 908 citations

Voltage sensor of excitation-contraction coupling in skeletal muscle.

1991 • 593 citations

Membrane Receptors and Hormone Action

1976 • 484 citations

The ryanodine receptor/Ca2+ release channel

1993 • 404 citations

Adenine nucleotide stimulation of Ca2+-induced Ca2+ release in sarcoplasmic reticulum.

1984 • 373 citations

Recent progress in hormone research

1990 • 359 citations

Control of Calcium Release in Functioning Skeletal Muscle Fibers

1994 • 293 citations

Dantrolene in Human Malignant Hyperthermia A Multicenter Study

1982 • 280 citations

Calcium Release from Skeletal Muscle Sarcoplasmic Reticulum: Site of Action of Dantrolene Sodium?

1976 • 242 citations

CONTROL OF THE MALIGNANT HYPERPYREXIC SYNDROME IN MHS SWINE BY DANTROLENE SODIUM

1975 • 235 citations

Calcium-ryanodine receptor complex. Solubilization and partial characterization from skeletal muscle junctional sarcoplasmic reticulum vesicles.

1986 • 224 citations

Receptor-ligand interactions; a practical approach

1993 • 200 citations

Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel.

1990 • 190 citations

Methods in neurotransmitter receptor analysis

1991 • 178 citations

Activation of the skeletal muscle calcium release channel by a cytoplasmic loop of the dihydropyridine receptor.

1994 • 176 citations

1-[5-Arylfurfurylidene)amino]hydantoins. A New Class of Muscle Relaxants

1967 • 171 citations

Charge Movement and the Nature of Signal Transduction in Skeletal Muscle Excitation-Contraction Coupling

1992 • 153 citations

Localization and partial characterization of the oligomeric disulfide-linked molecular weight 95,000 protein (triadin) which binds the ryanodine and dihydropyridine receptors in skeletal muscle triadic vesicles

1991 • 145 citations

The Calcium Channel: Structure, Function and Implications

1988 • 130 citations

Myoplasmic free [Ca²⁺] during a malignant hyperthermia episode in swine

1988 • 96 citations

Pharmacological studies of charge movement in frog skeletal muscle.

1983 • 86 citations

Dantrolene, a Direct Acting Skeletal Muscle Relaxant

1973 • 80 citations

Comparison of [3H]ryanodine receptors and Ca++ release from rat cardiac and rabbit skeletal muscle sarcoplasmic reticulum.

1991 • 79 citations

Dantrolene in Porcine Malignant Hyperthermia

1976 • 78 citations

Malignant Hyperthermia

1992 • 75 citations

DANTROLENE—DYNAMICS AND KINETICS

1988 • 75 citations

Direct binding of verapamil to the ryanodine receptor channel of sarcoplasmic reticulum

1990 • 71 citations

Effects of Dantrolene on Myoplasmic Free [Ca2+] Measured In Vivo in Patients Susceptible to Malignant Hyperthermia

1992 • 67 citations

Altered binding site for Ca2+ in the ryanodine receptor of human malignant hyperthermia

1991 • 49 citations

Stimulation and inhibition of [3H]ryanodine binding to sarcoplasmic reticulum from malignant hyperthermia susceptible pigs

1990 • 42 citations

Effects of dantrolene sodium on the electrophysiological properties of canine cardiac Purkinje fibers.

1982 • 34 citations

Binding of dantrolene sodium to muscle intracellular membranes

1980 • 30 citations

The effect of dantrolene on skeletal-muscle sarcoplasmic-reticulum function in malignant hyperpyrexia in pigs

1983 • 30 citations

Simultaneous determination of dantrolene and its metabolites, 5-hydroxydantrolene and nitro-reduced acetylated dantrolene (F 490), in plasma and urine of man and dog by high-performance liquid chromatography

1982 • 27 citations

Azumolene Reverses Episodes of Malignant Hyperthermia in Susceptible Swine

1990 • 25 citations

1-[[[5-(Substituted phenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinediones, a new class of skeletal muscle relaxants

1987 • 22 citations

Muscle relaxant properties of the identified metabolites of dantrolene

1978 • 20 citations

EU 4093 Decreases Intracellular [Ca2+] in Skeletal Muscle Fibers from Control and Malignant Hyperthermia–Susceptible Swine

1992 • 20 citations

Receptor-ligand interactions — A practical approach

1993 • 19 citations

The Effects of Extracellular Magnesium on Myoplasmic [Ca2+] in Malignant Hyperthermia Susceptible Swine

1990 • 15 citations

In vitro binding of dantrolene to sarcoplasmic reticulum of rabbit skeletal muscle

1982 • 15 citations

Dantrolene and azumolene inhibit [3H] PN200-110 binding to porcine skeletal muscle dihydropyridine receptors

1992 • 14 citations

Triadic proteins of skeletal muscle

1989 • 14 citations

THE EFFECT OF AZUMOLENE ON HYPERCONTRACTILITY AND SARCOPLASMIC RETICULUM CA2+‐DEPENDENT ATPASE ACTIVITY OF MALIGNANT HYPERPYREXIASUSCEPTIBLE PORCINE SKELETAL MUSCLE

1991 • 9 citations

Separate sites for the dantrolene-induced inhibition of contracture of the rat diaphragm preparation due to depolarization or to caffeine

1991 • 9 citations

Study of the physicochemical properties of aqueous dantrolene solutions by differential pulse polarography

1988 • 5 citations

A comparison of the potency and specificity of the direct muscle relaxant activity of azumolene and dantrolene

1992 • 4 citations