An evolutionary view of drug-receptor interaction: the bioamine receptor family

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

PHYLOGENIES FROM MOLECULAR SEQUENCES: INFERENCE AND RELIABILITY

1988 • 2,143 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

Einfluss der Configuration auf die Wirkung der Enzyme

1894 • 1,695 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

International Union of Pharmacology nomenclature of adrenoceptors.

1994 • 1,173 citations

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A proposed new nomenclature for 5-HT receptors

1993 • 551 citations

How often do duplicated genes evolve new functions?

1995 • 414 citations

Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory

1995 • 303 citations

Partial agonists, full agonists, antagonists: dilemmas of definition

1993 • 234 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Molecular characterization of α1- and α2-adrenoceptors

1991 • 153 citations

A common step for signal transduction in G protein-coupled receptors

1994 • 152 citations

Multigene families and the evolution of complexity

1991 • 151 citations

Aspects of the Genesis and Maintenance of Biological Diversity

1996 • 150 citations

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

1991 • 146 citations

G protein-linked signaling pathways control the developmental program of dictyostelium

1994 • 145 citations

Mechanisms of multifunctional signalling by G protein-linked receptors

1993 • 143 citations

Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors.

1992 • 127 citations

Of mice and flies: commonalities among 5-HT receptors

1992 • 118 citations

New insights into dopamine receptors in the central nervous system

1993 • 108 citations

The Dopamine D1D Receptor

1995 • 107 citations

Receptor subtypes or species homologues: relevance to drug discovery

1993 • 98 citations

A Single Amino Acid Difference Accounts for the Pharmacological Distinctions Between the Rat and Human 5‐Hydroxytryptamine_1B Receptors

1993 • 89 citations

Functional constraints against variations on molecules from the tissue level: slowly evolving brain-specific genes demonstrated by protein kinase and immunoglobulin supergene families.

1995 • 65 citations

Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues.

1993 • 61 citations

Desensitization of the human beta 1-adrenergic receptor. Involvement of the cyclic AMP-dependent but not a receptor-specific protein kinase.

1991 • 54 citations

Analysis of the dopamine receptor family in the compact genome of the puffer fish Fugu rubripes

1995 • 53 citations

Selective coupling of alpha 2-adrenergic receptor subtypes to cyclic AMP-dependent reporter gene expression in transiently transfected JEG-3 cells.

1993 • 44 citations

Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain

1994 • 43 citations

Testing models of agonism for G protein-coupled receptors

1991 • 17 citations

Interpretation of relative potencies, relative efficacies and apparent affinity constants of agonist drugs estimated from concentration-response curves

1990 • 13 citations