Interleukin-4 stimulates cGMP production by IFN-gamma-activated human monocytes. Involvement of the nitric oxide synthase pathway

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.

1992 • 428 citations

Tumor Necrosis Factor and Granulocyte Macrophage-Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium avium and to Kill Avirulent M. avium: Killing Effector Mechanism Depends on the Generation of Reactive Nitrogen Intermediates

1991 • 390 citations

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

1991 • 351 citations

Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes

1993 • 334 citations

Molecular mechanisms of signal transduction in macrophages

1987 • 331 citations

Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

1989 • 311 citations

Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4.

1988 • 303 citations

Cytokine-Induced Synthesis of Nitrogen Oxides in Macrophages: A Protective Host Response to Leishmania and Other Intracellular Pathogens

1991 • 267 citations

Haem‐Dependent Activation of Guanylate Cyclase and Cyclic GMP Formation by Endogenous Nitric Oxide: A Unique Transduction Mechanism for Transcellular Signaling

1990 • 230 citations

IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma.

1989 • 228 citations

A possible novel pathway of regulation by murine T helper type‐2 (T_h2) cells of a T_h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

1991 • 226 citations

IL-4 inhibits superoxide production by human mononuclear phagocytes.

1990 • 211 citations

Activation of human macrophages for the killing of intracellular Trypanosoma cruzi by TNF-α and IFN-γ through a nitric oxide-dependent mechanism

1992 • 196 citations

L-Arginine-Dependent Reactive Nitrogen Intermediates and the Antimicrobial Effect of Activated Human Mononuclear Phagocytes

1992 • 182 citations

Changes in mechanisms of monocyte/macrophage-mediated cytotoxicity during culture. Reactive oxygen intermediates are involved in monocyte-mediated cytotoxicity, whereas reactive nitrogen intermediates are employed by macrophages in tumor cell killing.

1993 • 173 citations

Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate

1990 • 136 citations

Increased Circulating Nitrogen Oxides After Human Tumor Immunotherapy: Correlation With Toxic Hemodynamic Changes

1992 • 129 citations

Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation

1990 • 113 citations

Nitric oxide production by monocytes in alcoholic liver disease

1992 • 102 citations

Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro

1993 • 95 citations

Antagonistic and additive effects of IL-4 and lnterferon-γ on human monocytes and macrophages: Effects on Fc receptors, HLA-D antigens, and superoxide production

1990 • 93 citations

Cytokine interactions in experimental cutaneous leishmaniasis. Interleukin 4 synergizes with interferon‐γ to activate murine macrophages for killing of Leishmania major amastigotes

1991 • 82 citations

Ligation of CD23 triggers cAMP generation and release of inflammatory mediators in human monocytes.

1992 • 62 citations

Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states.

1988 • 34 citations

IL-4: Structure and Function

1992 • 33 citations

Interleukin-4 Signals Regulating CD23 Gene Expression in Human B Cells: Protein Kinase C-Independent Signaling Pathways

1993 • 17 citations