Increased intracellular phosphoribosylpyrophosphate and accelerated orotic acid decarboxylation in a mouse cell line resistant to purine and pyrimidine ribonucleosides

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Determination of Enzyme Dissociation Constants

1934 • 11,865 citations

Tissue Culture. Methods and Applications

1974 • 1,068 citations

GENETICS OF HUMAN CELL LINES, IV. DNA-MEDIATED HERITABLE TRANSFORMATION OF A BIOCHEMICAL TRAIT

1962 • 493 citations

Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

1966 • 484 citations

Current topics in cellular regulation

1971 • 325 citations

ENZYMATIC SYNTHESIS AND PROPERTIES OF 5-PHOSPHORIBOSYLPYROPHOSPHATE

1955 • 316 citations

Three Degrees of Guanylic Acid — Inosinic Acid Pyrophosphorylase Deficiency in Mouse Fibroblasts

1964 • 280 citations

Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis

1973 • 248 citations

Regulation of the synthesis of 5-phosphoribosyl-i-pyrophosphate in intact red blood cells and in cell-free preparations

1969 • 204 citations

Orotidylic Acid Decarboxylase: Inhibition Studies with Azauridine 5′-Phosphate

1960 • 186 citations

Human Phosphoribosylpyrophosphate Synthetase

1972 • 163 citations

Allopurinol: Alteration in Pyrimidine Metabolism in Man

1970 • 151 citations

The Biochemical Activity of 6-Azauridine: Interference with Pyrimidine Metabolism in Transplantable Mouse Tumors

1959 • 136 citations

Mutations affecting adenine phosphoribosyl transferase activity in Chinese hamster cells

1974 • 133 citations

A biochemical study of the growth of Drosophila melanogaster

1966 • 129 citations

Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity

1973 • 118 citations

Gout with purine overproduction due to increased phosphoribosylpyrophosphate synthetase activity

1973 • 111 citations

Feedback onhibition of uridine kinase by cytidine triphosphate and uridine triphosphate

1964 • 101 citations

Human erythrocyte phosphoribosylpyrophosphate synthetase mutationally altered in regulatory properties

1973 • 99 citations

Pyrimidine Nucleotide Synthesis: Regulatory Control during Transformation of Lymphocytes in vitro

1967 • 96 citations

Communication between normal and enzyme deficient cells in tissue culture

1972 • 93 citations

Repression and Derepression of Purine Biosynthesis in Mammalian Hepatoma Cells in Culture

1972 • 83 citations

Properties of Diploid Cell Strains Developed from Patients with an Inherited Abnormality of Uridine Biosynthesis

1964 • 77 citations

Human phosphoribosylpyrophosphate synthetase. Comparison of purified normal and mutant enzymes.

1975 • 76 citations

Purine ribonucleoside kinase activity and resistance to some analogs of adenosine.

1966 • 75 citations

Purine excretion by mammalian cells deficient in adenosine kinase

1973 • 70 citations

Characterization of a Feedback-Resistant Phosphoribosylpyrophosphate Synthetase from Cultured, Mutagenized Hepatoma Cells That Overproduce Purines

1973 • 70 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype.

1967 • 69 citations

Mutants of Chinese hamster cells resistant to adenosine

1975 • 53 citations

Stability and Regulation of Phosphoribosyl Pyrophosphate Synthetase from Rat Liver

1974 • 51 citations

Phosphoribosylpyrophosphate Overproduction, a New Metabolic Abnormality in the Lesch Nyhan Syndrome

1975 • 49 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains. II. Effects of 5-azaorotic acid, barbituric acid, and pyrimidine precursors on cellular phenotype.

1967 • 48 citations

RESISTANCE TO PURINE RIBONUCLEOSIDE ANALOGUES IN AN ASCITES TUMOR

1967 • 46 citations

Nature of mutations conferring resistance to 8-azaguanine in mouse cell lines

1974 • 45 citations

Divergent action mechanism of cAMP and dibutyryl cAMP on cell proliferation and macromolecular synthesis in HeLa S3 cultures

1973 • 45 citations

Evidence against the existence of guanosine and inosine kinases in human fibroblasts in tissue culture

1969 • 42 citations

A uridine kinase-deficient mutant of 3T3 and a selective method for cells containing the enzyme

1974 • 40 citations

The Partial Purification and Properties of Uridine Kinase from Ehrlich Ascites Tumor Cells

1973 • 40 citations

Screening Tissue Cultures for Mycoplasma Infections11Supported, in part, by research contract NIH 69-2053 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

1973 • 38 citations

Phosphoribosylpyrophosphate Synthetase Is Elevated in Fibroblasts from Patients with the Lesch-Nyhan Syndrome

1976 • 35 citations

Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts

1971 • 35 citations

Purine Metabolism in Normal and Thioguanine-Resistant Neuroblastoma

1973 • 32 citations

Hereditary Orotic Aciduria: Evidence for a Structural Gene Mutation

1974 • 30 citations

Dihydroorotic Acid Dehydrogenase Activity of Human Diploid Cell Strains

1968 • 30 citations

Increased PRPP synthetase activity in cultured rat hepatoma cells containing mutations in the hypoxanthine‐guanine phosphoribosyltransferase gene

1976 • 25 citations

Mechanism of allopurinol-mediated inhibition and stabilization of human orotate phosphoribosyltransferase and orotidine phosphate decarboxylase

1976 • 23 citations

DEAE paper chromatography to separate intermediates of the pyrimidine biosynthetic pathway and to assay aspartate transcarbamylase and dihydroorotase activities

1973 • 21 citations

Determination of the intracellular concentration of 5-phosphoribosyl-1-pyrophosphate in cultured mammalian fibroblasts

1976 • 18 citations

Concurrent development of resistance to 6‐azauridine and adenosine in a mouse cell line

1975 • 16 citations

Studies of the orotidine 5?-monophosphate decarboxylase activity of crude extracts of human cells

1973 • 10 citations